Published in Oncogene on August 16, 2010
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proc Natl Acad Sci U S A (2011) 2.01
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. Proc Natl Acad Sci U S A (2013) 1.57
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene (2011) 1.54
p21-activated kinase 1: PAK'ed with potential. Oncotarget (2011) 1.44
PAK signaling in cancer. Cell Logist (2012) 1.27
Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations. Clin Cancer Res (2012) 1.22
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther (2013) 1.21
A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One (2013) 1.17
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene (2014) 1.09
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res (2013) 1.09
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion. J Cell Biol (2011) 1.08
Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res (2012) 1.06
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics (2011) 1.06
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases (2010) 1.00
Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia (2012) 0.99
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol (2012) 0.96
Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integr Biol (Camb) (2013) 0.96
Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget (2014) 0.95
Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival. PLoS One (2012) 0.95
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Front Pharmacol (2013) 0.93
S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1. Cell Rep (2012) 0.93
CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling. Oncogene (2012) 0.91
Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. PLoS One (2011) 0.91
Mouse models of PAK function. Cell Logist (2012) 0.89
The pak4 protein kinase in breast cancer. ISRN Oncol (2012) 0.88
The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells. Oncogenesis (2013) 0.87
Human epidermal growth factor receptor signaling in acute lung injury. Am J Respir Cell Mol Biol (2012) 0.86
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. J Biol Chem (2013) 0.85
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. PLoS One (2013) 0.84
PAK4-6 in cancer and neuronal development. Cell Logist (2012) 0.83
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol (2015) 0.83
ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem (2013) 0.81
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Analysis of substrates of protein kinase C isoforms in human breast cells by the traceable kinase method. Biochemistry (2012) 0.79
Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt. J Mol Signal (2010) 0.79
Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene (2015) 0.79
When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase. Cells (2014) 0.78
Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
A nanotopography approach for studying the structure-function relationships of cells and tissues. Cell Adh Migr (2015) 0.77
HER2 and β-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations. Clin Exp Metastasis (2015) 0.77
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? Oncotarget (2016) 0.77
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation. Int J Cancer Clin Res (2015) 0.76
Arpin downregulation in breast cancer is associated with poor prognosis. Br J Cancer (2016) 0.75
A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth. Sci Rep (2017) 0.75
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. Oncotarget (2016) 0.75
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis. Mol Endocrinol (2015) 0.75
3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response. BMC Cancer (2016) 0.75
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun (2017) 0.75
Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling. Oncotarget (2017) 0.75
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res (1990) 9.85
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther (1996) 7.12
Construction of adenovirus vectors through Cre-lox recombination. J Virol (1997) 6.72
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst (2004) 6.55
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol (2001) 6.21
ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol (2009) 4.40
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J (1996) 3.22
Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene (2000) 2.71
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst (2006) 2.71
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34
Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol (2008) 2.02
The genetics of Pak. J Cell Sci (2004) 2.00
PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene (2006) 1.57
HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res (2006) 1.52
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol (2007) 1.38
Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene (1998) 1.38
Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res (2006) 1.37
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther (2009) 1.36
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One (2009) 1.29
Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Cancer Res (2006) 1.20
The activation of an extracellular signal-regulated kinase by oestradiol interferes with the effects of trastuzumab on HER2 signalling in endometrial adenocarcinoma cell lines. Eur J Cancer (2003) 0.86
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39
Transcriptional regulation and function during the human cell cycle. Nat Genet (2001) 5.89
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science (1998) 3.64
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res (2001) 3.18
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J (1998) 3.03
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol (1999) 2.84
A generic intron increases gene expression in transgenic mice. Mol Cell Biol (1991) 2.75
Regulation of carbamoyl phosphate synthetase by MAP kinase. Nature (2000) 2.72
Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem (1995) 2.69
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol (2001) 2.58
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem (2000) 2.51
Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol (1998) 2.48
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J Biol Chem (1996) 2.45
Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol (1997) 2.44
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene (2001) 2.25
Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity (1998) 2.23
Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients. Hum Reprod (2012) 2.12
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. Cell (1997) 2.12
Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU Int (2004) 2.09
Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem (1995) 2.08
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem (1998) 2.06
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev (1994) 2.05
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J (1995) 2.00
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1994) 2.00
Natural course of schizophrenia: 2-year follow-up study in a rural Chinese community. Br J Psychiatry (2001) 1.96
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol (1997) 1.94
The biogenesis of mitochondria. II. The influence of medium composition on the cytology of anaerobically grown Saccharomyces cerevisiae. J Cell Biol (1968) 1.92
The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J Biol Chem (1996) 1.91
Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol (2000) 1.82
Starting window, a distinct element in the cap-independent internal initiation of translation on picornaviral RNA. J Mol Biol (1994) 1.72
Genetic analysis of mutant strains of Escherichia coli requiring p-aminobenzoic acid for growth. J Bacteriol (1967) 1.71
Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder. J Urol (2004) 1.69
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem (2000) 1.64
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene (1995) 1.63
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Oncogene (2011) 1.59
Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). J Biol Chem (1996) 1.58
The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins. Virology (1989) 1.58
Structure and mutational analysis of Rab GDP-dissociation inhibitor. Nature (1996) 1.56
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. Biochem J (1997) 1.56
Depression during pregnancy and the postpartum period in adolescent and adult Portuguese mothers. Arch Womens Ment Health (2007) 1.56
Coasting acts through downregulation of VEGF gene expression and protein secretion. Hum Reprod (2004) 1.56
High-throughput quantitative analysis of hepatitis B virus DNA in serum using the TaqMan fluorogenic detection system. Hepatology (2000) 1.52
Biosynthesis of 4-aminobenzoate in Escherichia coli. J Bacteriol (1970) 1.52
Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J Cell Biol (1998) 1.51
Chloramphenicol inhibition of the formation of particulate mitochondrial enzymes of Saccharomyces cerevisiae. Biochim Biophys Acta (1966) 1.50
Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol (2001) 1.47
Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Res (2000) 1.46
Characterization of human immunodeficiency virus type 1 matrix revertants: effects on virus assembly, Gag processing, and Env incorporation into virions. J Virol (1997) 1.40
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.37
Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem (1997) 1.37
Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol (1996) 1.36
Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. J Biol Chem (2001) 1.36
Partial splenic embolization for hypersplenism in cirrhosis: a long-term outcome in 62 patients. Dig Liver Dis (2008) 1.35
Anisotropy of human muscle via non-invasive impedance measurements. Phys Med Biol (1997) 1.34
Roles for glycosylation of cell surface receptors involved in cellular immune recognition. J Mol Biol (1999) 1.32
Epitope-tag vectors for eukaryotic protein production. Gene (1995) 1.30
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. Proc Natl Acad Sci U S A (1994) 1.27
Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Curr Biol (1998) 1.27
Influence of bone densitometry results on the treatment of osteoporosis. CMAJ (2001) 1.24
The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Mol Cell Biol (1992) 1.23
Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci U S A (2000) 1.23
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. Cancer Res (2001) 1.22
Profilin enhances Cdc42-induced nucleation of actin polymerization. J Cell Biol (2000) 1.21
Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem (1998) 1.21
Femtosecond spectroscopic observations of initial intermediates in the photocycle of the photoactive yellow protein from Ectothiorhodospira halophila. Biophys J (1999) 1.19
RS3PE syndrome presenting as vascular endothelial growth factor associated disorder. Ann Rheum Dis (2005) 1.18
Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart. J Biol Chem (1983) 1.18
Lentivirus Nef specifically activates Pak2. J Virol (2000) 1.18
Adenosine-elicited accumulation of cyclic AMP in brain slices: potentiation by agents which inhibit uptake of adenosine. Life Sci (1974) 1.17
Degenerin similarities. Nature (1993) 1.17
Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library. Eur J Immunol (2001) 1.16
Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats. Am J Physiol Heart Circ Physiol (2007) 1.15
The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells. Diabetologia (2010) 1.14
Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci (2001) 1.14
Plant GTPases: the Rhos in bloom. Trends Cell Biol (2000) 1.14
Magnetoencephalography reveals early activation of V4 in grapheme-color synesthesia. Neuroimage (2010) 1.13
A phosphotyrosyl-protein phosphatase activity associated with acid phosphatase from human prostate gland. Eur J Biochem (1984) 1.13
A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proc Natl Acad Sci U S A (1991) 1.12
Elliptic flow of charged particles in Pb-Pb collisions at sqrt[S(NN)] = 2.76 TeV. Phys Rev Lett (2010) 1.12
Functional elements of the steroid hormone-responsive promoter of mouse mammary tumor virus. J Virol (1990) 1.12
Particle-yield modification in jetlike azimuthal dihadron correlations in Pb-Pb collisions at √s(NN)=2.76 TeV. Phys Rev Lett (2012) 1.11
Restoration of mucociliary tracheal epithelium following deprivation of vitamin A. A quantitative morphologic study. Virchows Arch B Cell Pathol Incl Mol Pathol (1984) 1.11
Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene (2011) 1.11
A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase. Arch Biochem Biophys (1985) 1.10
The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J Pharmacol Exp Ther (2011) 1.10
Characterization of emm types and superantigens of Streptococcus pyogenes isolates from children during two sampling periods. Epidemiol Infect (2009) 1.09
E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. Oncogene (2006) 1.09
Effects of atmospheric hydrogen sulfide concentration on growth and meat quality in broiler chickens. Poult Sci (2011) 1.08
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Mol Cell Biol (1998) 1.08
Transverse momentum distribution and nuclear modification factor of charged particles in p+Pb collisions at sqrt[s(NN)] = 5.02 TeV. Phys Rev Lett (2013) 1.08
High preoparative levels of serum periostin are associated with poor prognosis in patients with hepatocellular carcinoma after hepatectomy. Eur J Surg Oncol (2013) 1.07
An evaluation of falls, syncope, and dizziness by prolonged ambulatory cardiographic monitoring in a geriatric institutional setting. J Am Geriatr Soc (1982) 1.07