Published in Cell Logist on April 01, 2012
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem (2013) 1.09
PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways. Biosci Rep (2014) 1.00
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med (2013) 0.94
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res (2015) 0.93
Roles of rho GTPases in intracellular transport and cellular transformation. Int J Mol Sci (2013) 0.88
Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profiling. PLoS One (2013) 0.85
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep (2014) 0.84
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. PLoS One (2013) 0.84
PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition. J Pathol (2014) 0.82
The PAKs come of age: Celebrating 18 years of discovery. Cell Logist (2012) 0.80
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis. Oncotarget (2015) 0.79
PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Sci Rep (2015) 0.79
A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases. PLoS One (2015) 0.79
FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine. BMC Cancer (2016) 0.79
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1. Mol Biol Cell (2013) 0.78
Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep (2013) 0.78
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett (2015) 0.77
Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells. Onco Targets Ther (2014) 0.77
The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1). J Biol Chem (2015) 0.77
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells. Korean J Physiol Pharmacol (2014) 0.76
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events. Biochim Biophys Acta (2016) 0.75
ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion. Oncotarget (2015) 0.75
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis. Mol Endocrinol (2015) 0.75
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Sci Rep (2017) 0.75
PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway. Diagn Pathol (2015) 0.75
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther (2017) 0.75
Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. Int J Clin Exp Pathol (2015) 0.75
PAK2 promotes migration and proliferation of salivary gland adenoid cystic carcinoma. Am J Transl Res (2016) 0.75
Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells. BMC Cancer (2016) 0.75
High expression of P21-activated kinase 5 protein is associated with poor survival in gastric cancer. Oncol Lett (2017) 0.75
Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis. Oncogene (2017) 0.75
Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss. Med Microbiol Immunol (2014) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
A landscape of driver mutations in melanoma. Cell (2012) 12.61
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Colorectal cancer: mutations in a signalling pathway. Nature (2005) 5.42
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol (2008) 4.81
p21-activated kinases in cancer. Nat Rev Cancer (2006) 4.24
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (1998) 2.93
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst (2006) 2.71
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J (1997) 2.57
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem (2000) 2.51
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
MEK kinase activity is not necessary for Raf-1 function. EMBO J (2001) 2.36
A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell (2004) 2.35
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res (2008) 2.32
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol (2003) 2.20
SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell (2010) 2.18
Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J Muscle Res Cell Motil (1998) 2.14
Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene (2008) 2.12
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell (2005) 2.11
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther (2008) 2.09
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res (2005) 2.09
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem (2001) 2.07
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proc Natl Acad Sci U S A (2011) 2.01
Amplification of 11q13 in ovarian carcinoma. Genes Chromosomes Cancer (2008) 2.01
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol (1996) 2.00
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem (2001) 1.96
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol (1997) 1.94
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A (2010) 1.94
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer Cell (2004) 1.93
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem (2000) 1.90
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J (2004) 1.85
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem (2002) 1.82
Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res (2007) 1.80
Activated PAK4 regulates cell adhesion and anchorage-independent growth. Mol Cell Biol (2001) 1.76
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J (2002) 1.75
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem (2005) 1.73
p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J Biol Chem (2003) 1.70
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem (2004) 1.69
Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res (2004) 1.65
Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. J Biol Chem (2006) 1.63
The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. EMBO J (2008) 1.61
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol (2000) 1.60
P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res (2006) 1.58
PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene (2006) 1.57
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene (2011) 1.54
B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms. J Biol Chem (2005) 1.54
Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Biochem J (2005) 1.53
The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem (2000) 1.53
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene (2010) 1.53
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol (2003) 1.51
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem (2000) 1.49
A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene (2011) 1.49
The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer Res (2008) 1.48
Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma. Cytogenet Cell Genet (1997) 1.48
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. Breast Cancer Res Treat (2003) 1.47
Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem (2000) 1.45
Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene (2007) 1.43
Control of cell migration: a tumour suppressor function for p53? Biol Cell (2006) 1.39
Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells. Oncogene (1998) 1.38
p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I. Circ Res (2002) 1.37
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem (2005) 1.34
Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem (2001) 1.34
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. EMBO Rep (2004) 1.34
High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia (2004) 1.33
Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function. Oncogene (2004) 1.32
Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res (2008) 1.31
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem (2004) 1.30
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Mol Pharmacol (2007) 1.29
p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts. J Biol Chem (2001) 1.29
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. J Biol Chem (2003) 1.28
p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow. Circ Res (2008) 1.28
Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett (2003) 1.27
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene (2002) 1.27
P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene (2008) 1.26
Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J Biol Chem (1998) 1.26
P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. Biochim Biophys Acta (2010) 1.25
Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate (2008) 1.24
Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells (2002) 1.22
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol (2004) 1.21
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal (2011) 1.21
Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene. J Exp Med (1992) 1.21
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci (2007) 1.20
Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase. Biochem Biophys Res Commun (2002) 1.20
p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol Cell Biol (2005) 1.19
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene (2005) 1.19
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem (2006) 1.94
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem (2005) 1.34
Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53. Chem Res Toxicol (2002) 1.28
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol (2004) 1.26
Schwann cells: origins and role in axonal maintenance and regeneration. Int J Biochem Cell Biol (2006) 1.23
Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells. Cancer Lett (2005) 1.13
Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis. J Cell Sci (2008) 1.09
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem (2013) 1.09
Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. Cancer Res (2003) 0.99
Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J Biol Chem (2003) 0.98
Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection. Chem Res Toxicol (2006) 0.97
Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. J Biol Chem (2013) 0.96
The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol (2008) 0.95
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS One (2011) 0.93
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association. J Biol Chem (2006) 0.87
Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle. Cell Cycle (2011) 0.83
Melamine and Cyanuric Acid do not interfere with Bradford and Ninhydrin assays for protein determination. Food Chem (2010) 0.82
p53 Mutagenesis by benzo[a]pyrene derived radical cations. Chem Res Toxicol (2012) 0.81
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. Chem Res Toxicol (2011) 0.80
The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis. Mutat Res (2012) 0.78
Targeting PAK etk... Cancer Biol Ther (2004) 0.75
Amplifying Pak kinases. Cancer Biol Ther (2008) 0.75
Erratum: CAP2 in cardiac conduction, sudden cardiac death and eye development. Sci Rep (2016) 0.75