Published in Neurosci Lett on June 03, 2004
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res (2008) 1.84
Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin Proc (2011) 1.79
Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats. Neurorehabil Neural Repair (2007) 1.48
The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. Neurosci Biobehav Rev (2012) 1.45
Treatment of Parkinson's disease with trophic factors. Neurotherapeutics (2008) 1.35
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Curr Top Behav Neurosci (2013) 1.25
Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor. J Neural Transm (Vienna) (2005) 1.16
Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control. Exp Physiol (2009) 1.11
Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levels. Neuroscience (2011) 1.08
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Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci (2012) 1.01
Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis. Front Behav Neurosci (2010) 0.98
Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience (2006) 0.97
Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone. Eur J Neurosci (2008) 0.97
Strength training does not influence serum brain-derived neurotrophic factor. Eur J Appl Physiol (2010) 0.97
BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory. Neurobiol Learn Mem (2010) 0.97
Neuropeptides in depression: role of VGF. Behav Brain Res (2008) 0.97
Sex differences in the effectiveness of treadmill training in enhancing axon regeneration in injured peripheral nerves. Dev Neurobiol (2012) 0.96
Enhancing recovery from peripheral nerve injury using treadmill training. Ann Anat (2011) 0.96
Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus (2014) 0.96
The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt. Brain Res (2009) 0.96
Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol (2011) 0.96
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV. Transl Psychiatry (2011) 0.89
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int (2006) 0.87
Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury. Eur J Neurosci (2011) 0.86
The recent understanding of the neurotrophin's role in skeletal muscle adaptation. J Biomed Biotechnol (2011) 0.86
Drugs in sport: a scientist-athlete's perspective: from ambition to neurochemistry. Br J Pharmacol (2008) 0.86
On aerobic exercise and behavioral and neural plasticity. Brain Sci (2012) 0.86
Housing in environmental complexity following wheel running augments survival of newly generated hippocampal neurons in a rat model of binge alcohol exposure during the third trimester equivalent. Alcohol Clin Exp Res (2012) 0.85
Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons. Neurobiol Learn Mem (2014) 0.84
The effects of aerobic exercise intensity and duration on levels of brain-derived neurotrophic factor in healthy men. J Sports Sci Med (2013) 0.84
No effect of running and laboratory housing on adult hippocampal neurogenesis in wild caught long-tailed wood mouse. BMC Neurosci (2009) 0.83
Exercise and environment as an intervention for neonatal alcohol effects on hippocampal adult neurogenesis and learning. Neuroscience (2014) 0.82
The effects of two forms of physical activity on eyeblink classical conditioning. Behav Brain Res (2011) 0.81
Low BDNF is associated with cognitive deficits in patients with type 2 diabetes. Psychopharmacology (Berl) (2012) 0.80
The effect of regular Taekwondo exercise on Brain-derived neurotrophic factor and Stroop test in undergraduate student. J Exerc Nutrition Biochem (2015) 0.80
Different regulation of adult hippocampal neurogenesis in Western house mice (Mus musculus domesticus) and C57BL/6 mice. Behav Brain Res (2011) 0.79
Age-related degeneration in leg-extensor muscle-tendon units decreases recovery performance after a forward fall: compensation with running experience. Eur J Appl Physiol (2006) 0.79
Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor. BMC Neurosci (2010) 0.77
Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory. Brain Res (2016) 0.77
Role of neuronal ras activity in adult hippocampal neurogenesis and cognition. Front Neurosci (2011) 0.77
Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment. Transl Psychiatry (2016) 0.77
Brain electrical activities of dancers and fast ball sports athletes are different. Cogn Neurodyn (2014) 0.76
Harnessing brain and cognitive reserve for the prevention of dementia. Indian J Psychiatry (2009) 0.76
Effect of exercise training on long-term potentiation and NMDA receptor channels in rats with cerebral infarction. Exp Ther Med (2013) 0.75
Exercise-induced neuroprotection in the spastic Han Wistar rat: the possible role of brain-derived neurotrophic factor. Biomed Res Int (2015) 0.75
Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem (2016) 0.75
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. Psychopharmacology (Berl) (2011) 0.75
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.27
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol (2003) 2.02
Patterned cell culture inside microfluidic devices. Lab Chip (2004) 1.89
Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc (2002) 1.81
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir (2003) 1.72
Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma (2005) 1.60
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci (2004) 1.54
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis (2002) 1.51
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol (2013) 1.45
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging (2005) 1.44
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement (2009) 1.36
Exercise enhances and protects brain function. Exerc Sport Sci Rev (2002) 1.35
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem (2003) 1.32
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res (2007) 1.30
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis (2012) 1.20
Spatial and temporal gene expression profiling of the contused rat spinal cord. Exp Neurol (2004) 1.20
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci (2007) 1.20
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem (2007) 1.19
Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci (2003) 1.19
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis (2010) 1.19
Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma (2004) 1.17
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006) 1.17
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One (2010) 1.15
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry (2002) 1.10
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology (2013) 1.10
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging (2012) 1.10
Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination. J Neurochem (2010) 1.04
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis (2003) 1.03
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem (2013) 1.03
Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis (2003) 1.02
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci (2012) 1.01
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging (2006) 1.01
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci (2004) 1.01
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol (2005) 1.00
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging (2010) 0.99
Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res (2002) 0.97
Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res (2004) 0.97
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci (2002) 0.96
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol (2002) 0.96
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res (2008) 0.96
Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord (2004) 0.94
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem (2006) 0.94
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol (2013) 0.93
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res (2003) 0.92
External force-assisted cell positioning inside microfluidic devices. Biomed Microdevices (2007) 0.92
Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury. Behav Brain Res (2007) 0.91
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One (2011) 0.90
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol (2004) 0.90
Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses. J Cell Physiol (2012) 0.89
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci (2004) 0.89
Voluntary running attenuates age-related deficits following SCI. Exp Neurol (2007) 0.88
Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease. J Hepatol (2011) 0.88
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging (2011) 0.88
Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. J Alzheimers Dis (2012) 0.88
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci (2010) 0.87
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci (2002) 0.87
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int (2006) 0.87
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.86
Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med (2008) 0.86
Identity-by-descent mapping to detect rare variants conferring susceptibility to multiple sclerosis. PLoS One (2013) 0.85
Exercise-induced gene expression changes in the rat spinal cord. Gene Expr (2005) 0.85
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.84
Differential gene expression in the EphA4 knockout spinal cord and analysis of the inflammatory response following spinal cord injury. PLoS One (2012) 0.84
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis (2007) 0.83
Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging (2005) 0.83
Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res (2007) 0.83
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine (2006) 0.83
Mild stress facilitates learning and exercise improves retention in aged mice. Exp Gerontol (2010) 0.82
Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res (2004) 0.81
Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr) (2011) 0.81
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol (2009) 0.81
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis (2010) 0.81
Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol (2006) 0.80