Published in J Neurosci on July 28, 2004
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A (2007) 1.91
Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm (Vienna) (2005) 1.85
Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav (2008) 1.80
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell (2009) 1.45
7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2011) 1.40
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr Alzheimer Res (2008) 1.26
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. Genome Biol (2008) 1.22
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci (2009) 1.19
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem (2009) 1.16
Elk-1 a transcription factor with multiple facets in the brain. Front Neurosci (2011) 1.15
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons. Mol Neurodegener (2011) 1.14
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity. J Biol Chem (2012) 1.11
Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2011) 1.08
Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. J Neurochem (2007) 1.07
Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One (2010) 1.06
Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med (2006) 1.03
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice. Neurobiol Aging (2010) 1.03
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem (2013) 1.03
DHA may prevent age-related dementia. J Nutr (2010) 1.02
Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice. FASEB J (2011) 1.00
Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats. Psychopharmacology (Berl) (2010) 0.99
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging (2010) 0.99
Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats. Am J Pathol (2011) 0.98
Neuroregeneration in neurodegenerative disorders. BMC Neurol (2011) 0.98
Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders. Neuropsychiatr Dis Treat (2013) 0.95
A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Front Aging Neurosci (2014) 0.91
The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Go alpha in an identified population of migratory neurons. Dev Biol (2005) 0.90
Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice. BMC Complement Altern Med (2014) 0.89
Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases. Biomed Res Int (2014) 0.88
Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiol Aging (2014) 0.86
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. J Neurosci (2013) 0.85
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One (2014) 0.85
Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res (2007) 0.83
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis (2007) 0.83
Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice. J Neurosci (2013) 0.82
Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PLoS One (2015) 0.82
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. PLoS One (2012) 0.81
Effects of immunomodulatory substances on phagocytosis of abeta(1-42) by human microglia. Int J Alzheimers Dis (2010) 0.81
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol Neurodegener (2015) 0.80
Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. ACS Chem Neurosci (2012) 0.80
The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC Neurosci (2006) 0.80
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. J Alzheimers Dis (2010) 0.79
Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases. Rev Neurosci (2015) 0.79
Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics (2015) 0.79
Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model. Endocrinol Metab (Seoul) (2014) 0.78
The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory. Front Integr Neurosci (2016) 0.78
Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. J Alzheimers Dis (2011) 0.78
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy? Front Aging Neurosci (2017) 0.77
The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ. Hum Mol Genet (2015) 0.77
Beta-amyloid 25-35 peptide reduces the expression of glutamine transporter SAT1 in cultured cortical neurons. Neurochem Res (2007) 0.77
Toxin-Induced Experimental Models of Learning and Memory Impairment. Int J Mol Sci (2016) 0.76
Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. PLoS One (2015) 0.76
Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease. Mol Med Rep (2016) 0.76
The mitochondrial aspartate/glutamate carrier isoform 1 gene expression is regulated by CREB in neuronal cells. Int J Biochem Cell Biol (2015) 0.75
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity. Front Pharmacol (2014) 0.75
Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies. Int J Mol Sci (2017) 0.75
Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiol Aging (2016) 0.75
TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains. Int J Alzheimers Dis (2011) 0.75
The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease. Mol Med (2017) 0.75
The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide. Cell Mol Neurobiol (2012) 0.75
Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy. Neural Regen Res (2017) 0.75
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.27
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol (2003) 2.02
Patterned cell culture inside microfluidic devices. Lab Chip (2004) 1.89
Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc (2002) 1.81
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir (2003) 1.72
Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma (2005) 1.60
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis (2002) 1.51
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging (2005) 1.44
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement (2009) 1.36
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem (2003) 1.32
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res (2007) 1.30
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett (2004) 1.28
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis (2012) 1.20
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci (2007) 1.20
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem (2007) 1.19
Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci (2003) 1.19
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis (2010) 1.19
Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma (2004) 1.17
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006) 1.17
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One (2010) 1.15
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry (2002) 1.10
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology (2013) 1.10
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging (2012) 1.10
Letter to the editor and authors' response: reaction to Abi-Rached JM (2012): from brain to neuro: the brain research association and the making of British neuroscience, 1965-1996. Journal of the History of the Neurosciences 21:189-213). J Hist Neurosci (2013) 1.08
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis (2003) 1.03
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem (2013) 1.03
Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis (2003) 1.02
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci (2012) 1.01
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging (2006) 1.01
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci (2004) 1.01
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol (2005) 1.00
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging (2010) 0.99
Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res (2002) 0.97
Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res (2004) 0.97
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res (2008) 0.96
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci (2002) 0.96
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol (2002) 0.96
Association of diuretic use and overactive bladder syndrome in older adults: a propensity score analysis. Arch Gerontol Geriatr (2008) 0.96
Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord (2004) 0.94
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem (2006) 0.94
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol (2013) 0.93
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res (2003) 0.92
External force-assisted cell positioning inside microfluidic devices. Biomed Microdevices (2007) 0.92
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One (2011) 0.90
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol (2004) 0.90
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci (2004) 0.89
Voluntary running attenuates age-related deficits following SCI. Exp Neurol (2007) 0.88
Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. J Alzheimers Dis (2012) 0.88
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging (2011) 0.88
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci (2010) 0.87
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci (2002) 0.87
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int (2006) 0.87
Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med (2008) 0.86
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.86
Exercise-induced gene expression changes in the rat spinal cord. Gene Expr (2005) 0.85
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.84
Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging (2005) 0.83
A module on death and dying to develop empathy in student pharmacists. Am J Pharm Educ (2011) 0.83
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine (2006) 0.83
Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res (2007) 0.83
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis (2007) 0.83
Mild stress facilitates learning and exercise improves retention in aged mice. Exp Gerontol (2010) 0.82
Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res (2004) 0.81
Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr) (2011) 0.81
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis (2010) 0.81
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol (2009) 0.81
Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res (2003) 0.80
Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol (2006) 0.80
Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem (2014) 0.80
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging (2010) 0.80
Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers. Alzheimers Dement (2012) 0.80
Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. ACS Chem Neurosci (2012) 0.80
Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One (2011) 0.80
Clinical trials: new opportunities. J Gerontol A Biol Sci Med Sci (2012) 0.79
Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design. Neuroepidemiology (2013) 0.78
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett (2002) 0.77
Nutritional management of brain aging in dogs. J Am Vet Med Assoc (2005) 0.77
A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging (2013) 0.77
Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol (2003) 0.77