Published in Proc Natl Acad Sci U S A on August 23, 2010
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
Hippo signaling: growth control and beyond. Development (2011) 5.25
The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol (2011) 4.63
The Hippo pathway: regulators and regulations. Genes Dev (2013) 4.55
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell (2015) 2.31
Hippo signaling in Drosophila: recent advances and insights. Dev Dyn (2011) 2.01
The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development (2010) 1.93
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
The Hippo signaling pathway and stem cell biology. Trends Cell Biol (2012) 1.84
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Organ size control by Hippo and TOR pathways. Curr Biol (2012) 1.45
Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie. PLoS Biol (2015) 1.45
Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane. Mol Syst Biol (2011) 1.44
Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell (2011) 1.43
Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Dev Cell (2015) 1.42
An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene (2013) 1.35
Mechanisms of cell competition: themes and variations. J Cell Biol (2013) 1.35
The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci (2014) 1.29
YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol (2015) 1.29
Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell (2012) 1.26
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep (2014) 1.24
Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development (2011) 1.19
Cell competition: how to eliminate your neighbours. Development (2014) 1.17
The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell (2012) 1.16
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol (2011) 1.15
Integration of intercellular signaling through the Hippo pathway. Semin Cell Dev Biol (2012) 1.14
Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation. Dev Cell (2012) 1.12
The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells. J Cell Biol (2013) 1.10
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol (2013) 1.10
WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis (2011) 1.09
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol (2013) 1.08
Sticking together the Crumbs - an unexpected function for an old friend. Nat Rev Mol Cell Biol (2013) 1.07
Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett (2014) 1.03
Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol (2013) 1.01
The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol (2013) 0.96
Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc Natl Acad Sci U S A (2014) 0.95
Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate. Dev Cell (2011) 0.95
Organ Size Control: Lessons from Drosophila. Dev Cell (2015) 0.95
Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol (2012) 0.94
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell (2011) 0.94
CRB2 mutations produce a phenotype resembling congenital nephrosis, Finnish type, with cerebral ventriculomegaly and raised alpha-fetoprotein. Am J Hum Genet (2014) 0.94
Signaling pathways in cell polarity. Cold Spring Harb Perspect Biol (2012) 0.92
Control of organ growth by patterning and hippo signaling in Drosophila. Cold Spring Harb Perspect Biol (2015) 0.92
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol (2013) 0.91
Polar delivery in plants; commonalities and differences to animal epithelial cells. Open Biol (2014) 0.90
Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules. Proc Natl Acad Sci U S A (2015) 0.89
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. PLoS Genet (2013) 0.89
Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. PLoS One (2012) 0.89
The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun (2016) 0.88
Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev Cell (2015) 0.88
Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development (2016) 0.88
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell (2015) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol (2016) 0.88
The Spectrin cytoskeleton regulates the Hippo signalling pathway. EMBO J (2015) 0.87
Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol (2011) 0.87
The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell (2012) 0.86
Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin. J Biol Chem (2015) 0.86
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. PLoS One (2012) 0.85
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
MST kinases in development and disease. J Cell Biol (2015) 0.84
The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet (2014) 0.84
The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue. Dev Cell (2015) 0.83
Hippo and rassf1a Pathways: A Growing Affair. Mol Biol Int (2012) 0.83
Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. Cell Cycle (2011) 0.83
Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PLoS One (2013) 0.82
SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Res (2014) 0.82
Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A (2014) 0.81
Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J (2014) 0.81
Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ (2012) 0.81
Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun (2015) 0.81
Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. Mech Dev (2014) 0.81
PML Surfs into HIPPO Tumor Suppressor Pathway. Front Oncol (2013) 0.80
Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Dev Biol (2013) 0.80
The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers (2014) 0.79
The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget (2016) 0.79
Novel neuroprotective function of apical-basal polarity gene crumbs in amyloid beta 42 (aβ42) mediated neurodegeneration. PLoS One (2013) 0.78
Expression of polarity genes in human cancer. Cancer Inform (2015) 0.77
Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells. Biol Open (2015) 0.77
Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis Yet Enables Highly Sensitive Lineage Tracing. Genetics (2016) 0.76
YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage. Bioessays (2016) 0.76
The hippo signaling pathway: implications for heart regeneration and disease. Clin Transl Med (2014) 0.76
Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control. PLoS One (2014) 0.75
The C. elegans Crumbs family contains a CRB3 homolog and is not essential for viability. Biol Open (2015) 0.75
Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis. Cancer Sci (2015) 0.75
Yorkie Facilitates Organ Growth and Metamorphosis in Bombyx. Int J Biol Sci (2016) 0.75
Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor. Cell Cycle (2015) 0.75
The Hippo pathway promotes cell survival in response to chemical stress. Cell Death Differ (2015) 0.75
Domain-specific functions of Stardust in Drosophila embryonic development. R Soc Open Sci (2016) 0.75
Signaling by the engulfment receptor draper: a screen in Drosophila melanogaster implicates cytoskeletal regulators, Jun N-terminal Kinase, and Yorkie. Genetics (2014) 0.75
Willing to Be Involved in Cancer. Genes (Basel) (2016) 0.75
Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell (2015) 0.75
Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells. PLoS One (2016) 0.75
Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy. Genes (Basel) (2016) 0.75
Disease implication of hyper-Hippo signalling. Open Biol (2016) 0.75
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol (2005) 6.74
Hippo signaling in organ size control. Genes Dev (2007) 6.29
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev (2010) 6.05
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer (2007) 5.78
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol (2003) 5.50
Delineation of a Fat tumor suppressor pathway. Nat Genet (2006) 5.06
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell (1995) 4.10
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol (2006) 3.90
The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol (2006) 3.83
crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell (1990) 3.79
Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature (2002) 3.22
Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet (2001) 3.22
The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell (2005) 3.17
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol (2010) 3.08
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell (2010) 2.96
The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development (2008) 2.86
Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol (2005) 2.77
Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell (2010) 2.73
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell (2009) 2.53
Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature (2002) 2.48
Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet (2006) 2.47
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A (2010) 2.43
Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development (2006) 2.43
Polarity complex proteins. Biochim Biophys Acta (2007) 2.42
The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell (2010) 2.34
Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A (2007) 2.31
Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene (2008) 2.30
Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature (2001) 2.12
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature (2001) 2.11
Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A (2008) 2.02
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol (2004) 1.87
Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J Cell Biol (2000) 1.84
Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol (2009) 1.77
A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Curr Biol (2000) 1.73
The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell (2006) 1.67
The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci (2009) 1.50
Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol (2002) 1.50
Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis. Int Rev Cytol (2007) 1.40
Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity. EMBO Rep (2006) 1.31
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res (2008) 1.30
Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Dev Biol (2009) 1.25
The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci (2009) 1.20
Crumbs is required to achieve proper organ size control during Drosophila head development. Development (2010) 1.10
Crumbs proteins in epithelial morphogenesis. Front Biosci (Landmark Ed) (2009) 1.07
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol (2005) 6.74
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol (2003) 5.50
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol (2006) 3.90
The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol (2006) 3.11
optix drives the repeated convergent evolution of butterfly wing pattern mimicry. Science (2011) 2.99
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A (2005) 2.96
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development (2002) 2.82
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A (2008) 2.02
Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain. Proc Natl Acad Sci U S A (2006) 1.79
The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem (2007) 1.69
Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in Heliconius erato. PLoS Genet (2010) 1.61
Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A (2008) 1.54
Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol (2006) 1.52
Mask is required for the activity of the Hippo pathway effector Yki/YAP. Curr Biol (2013) 1.48
Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J Infect Dis (2006) 1.46
Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies. BMC Genomics (2008) 1.36
GATA factors in Drosophila heart and blood cell development. Semin Cell Dev Biol (2005) 1.28
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand. Proc Natl Acad Sci U S A (2012) 1.26
Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A (2011) 1.26
Regulation of the Hippo pathway by cell architecture and mechanical signals. Semin Cell Dev Biol (2012) 1.20
The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci (2009) 1.20
Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J Infect Dis (2005) 1.13
Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem (2009) 0.92
Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet (2013) 0.92
Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol (2002) 0.91
Characterization of a dorsal-eye Gal4 Line in Drosophila. Genesis (2010) 0.89
Notch signaling activates Yorkie non-cell autonomously in Drosophila. PLoS One (2012) 0.88
MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca2+ signaling. Mol Reprod Dev (2004) 0.84
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells. PLoS One (2012) 0.83
Characterization of Frzb-Cre transgenic mouse. Genesis (2004) 0.79
Drosophila as an emerging model to study metastasis. Genome Biol (2004) 0.79
Stem cell proliferation in the skin: alpha-catenin takes over the hippo pathway. Sci Signal (2011) 0.77
Walter J. Gehring (1939-2014). Dev Biol (2014) 0.75