Published in J Nucleic Acids on July 25, 2010
Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases. Biochemistry (2014) 0.88
Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase η. J Biol Chem (2012) 0.85
Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae. DNA Repair (Amst) (2015) 0.80
Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9°N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance. J Biol Chem (2015) 0.78
Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. Biochimie (2015) 0.78
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87
hRAD30 mutations in the variant form of xeroderma pigmentosum. Science (1999) 7.40
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science (1999) 7.20
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Cell (2001) 5.93
DNA polymerases: structural diversity and common mechanisms. J Biol Chem (1999) 5.00
Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39
Comparison between DNA melting thermodynamics and DNA polymerase fidelity. Proc Natl Acad Sci U S A (1988) 4.07
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics (1997) 4.04
DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry (2004) 3.71
Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature (2004) 3.57
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J (2000) 3.46
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet (2000) 3.39
A new paradigm for DNA polymerase specificity. Biochemistry (2006) 3.25
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
poliota, a remarkably error-prone human DNA polymerase. Genes Dev (2000) 3.08
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Mol Cell (2001) 2.88
Low fidelity DNA synthesis by human DNA polymerase-eta. Nature (2000) 2.85
Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell (2001) 2.65
Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta. J Biol Chem (1999) 2.54
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Nucleic Acids Res (2001) 2.29
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts. Mol Cell Biol (2001) 2.28
Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA. J Am Chem Soc (2000) 2.24
Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem (2001) 2.15
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol (2009) 2.13
Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. J Biol Chem (1999) 2.11
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability. Mol Gen Genet (1998) 2.11
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem (2000) 2.06
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94
Yeast Rev1 protein is a G template-specific DNA polymerase. J Biol Chem (2002) 1.86
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry (2000) 1.75
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Cell (2001) 1.63
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63
Pre-steady-state kinetic studies of the fidelity of Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.57
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zeta. J Biol Chem (2005) 1.53
Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.52
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication. J Biol Chem (2004) 1.48
Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta. Proc Natl Acad Sci U S A (2003) 1.45
Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity. Nucleic Acids Res (2000) 1.41
Fidelity of the human mitochondrial DNA polymerase. J Biol Chem (2006) 1.40
Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase. Biochemistry (2006) 1.38
Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. J Biol Chem (2002) 1.33
Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4. J Mol Biol (2008) 1.29
Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Mol Cell Biol (2003) 1.27
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. J Mol Biol (2005) 1.26
DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes. Biochem J (1998) 1.24
The mutational specificity of the Dbh lesion bypass polymerase and its implications. J Biol Chem (2002) 1.23
Mechanism of abasic lesion bypass catalyzed by a Y-family DNA polymerase. J Biol Chem (2007) 1.23
Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base. Mol Cell Biol (2004) 1.19
Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-dihydro-8-oxoguanine by Saccharomyces cerevisiae DNA polymerase eta. Mol Cell Biol (2005) 1.15
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. J Mol Biol (2006) 1.14
DNA-thumb interactions and processivity of T7 DNA polymerase in comparison to yeast polymerase eta. J Biol Chem (2004) 1.07
Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chem Res Toxicol (2006) 1.06
Up-regulation of the fidelity of human DNA polymerase lambda by its non-enzymatic proline-rich domain. J Biol Chem (2006) 1.06
Mutations in the ubiquitin binding UBZ motif of DNA polymerase eta do not impair its function in translesion synthesis during replication. Mol Cell Biol (2007) 1.05
Global conformational dynamics of a Y-family DNA polymerase during catalysis. PLoS Biol (2009) 1.05
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01
The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme. Mol Cell Biol (2003) 1.01
Polymerization fidelity of a replicative DNA polymerase from the hyperthermophilic archaeon Sulfolobus solfataricus P2. Biochemistry (2009) 0.95
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2009) 0.93
Multiple functions of DNA polymerases. CRC Crit Rev Plant Sci (2007) 0.92
Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.91
Elucidating the kinetic mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase B1. Biochemistry (2009) 0.89
Biochemical, structural, and physiological characterization of terminal deoxynucleotidyl transferase. Chem Rev (2006) 0.89
Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein. Biochemistry (2007) 0.88
Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. DNA Repair (Amst) (2002) 0.86
Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. J Mol Biol (2009) 0.82
Division of labor at the eukaryotic replication fork. Mol Cell (2008) 4.41
DNA polymerases that propagate the eukaryotic DNA replication fork. Crit Rev Biochem Mol Biol (2005) 3.46
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proc Natl Acad Sci U S A (2010) 3.44
Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2. J Biol Chem (2002) 2.90
Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A (2003) 2.72
The PCNA-RFC families of DNA clamps and clamp loaders. Prog Nucleic Acid Res Mol Biol (2004) 2.53
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell (2006) 2.27
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol (2011) 2.20
The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding. J Biol Chem (2003) 2.19
Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick. J Biol Chem (2002) 2.17
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions. J Biol Chem (2006) 2.00
Crystal structure of a DNA decamer containing a cis-syn thymine dimer. Proc Natl Acad Sci U S A (2002) 1.82
Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions. J Biol Chem (2005) 1.80
Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem (2006) 1.70
Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control. Microbiol Mol Biol Rev (2009) 1.63
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63
The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins. Nucleic Acids Res (2006) 1.57
Pre-steady-state kinetic studies of the fidelity of Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.57
Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry (2011) 1.56
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zeta. J Biol Chem (2005) 1.53
Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.52
Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex. Mol Cell Biol (2005) 1.45
RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta. Nucleic Acids Res (2006) 1.43
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
A novel function of DNA polymerase zeta regulated by PCNA. EMBO J (2006) 1.40
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Nat Struct Mol Biol (2004) 1.40
A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage. J Biol Chem (2007) 1.39
Enzymatic switching for efficient and accurate translesion DNA replication. Nucleic Acids Res (2004) 1.30
The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proc Natl Acad Sci U S A (2006) 1.29
Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4. J Mol Biol (2008) 1.29
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
Pre-steady-state kinetic studies of the fidelity and mechanism of polymerization catalyzed by truncated human DNA polymerase lambda. Biochemistry (2004) 1.25
Mechanism of abasic lesion bypass catalyzed by a Y-family DNA polymerase. J Biol Chem (2007) 1.23
A novel mechanism of sugar selection utilized by a human X-family DNA polymerase. J Mol Biol (2009) 1.20
Single-turnover kinetic analysis of the mutagenic potential of 8-oxo-7,8-dihydro-2'-deoxyguanosine during gap-filling synthesis catalyzed by human DNA polymerases lambda and beta. J Mol Biol (2007) 1.14
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. J Mol Biol (2006) 1.14
Sloppy bypass of an abasic lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2007) 1.07
DNA-thumb interactions and processivity of T7 DNA polymerase in comparison to yeast polymerase eta. J Biol Chem (2004) 1.07
Stimulation of 3'-->5' exonuclease and 3'-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen. Mol Cell Biol (2002) 1.06
Up-regulation of the fidelity of human DNA polymerase lambda by its non-enzymatic proline-rich domain. J Biol Chem (2006) 1.06
Global conformational dynamics of a Y-family DNA polymerase during catalysis. PLoS Biol (2009) 1.05
DNA polymerase beta-dependent long patch base excision repair in living cells. DNA Repair (Amst) (2009) 1.05
Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya. Nucleic Acids Res (2007) 1.04
Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu. Biochemistry (2004) 1.00
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. EMBO J (2010) 0.98
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.97
Lesion bypass activities of human DNA polymerase mu. J Biol Chem (2002) 0.97
An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases. Nucleic Acids Res (2010) 0.96
Acceleration of 5-methylcytosine deamination in cyclobutane dimers by G and its implications for UV-induced C-to-T mutation hotspots. J Mol Biol (2009) 0.96
How the cell deals with DNA nicks. Cell Cycle (2005) 0.96
Polymerization fidelity of a replicative DNA polymerase from the hyperthermophilic archaeon Sulfolobus solfataricus P2. Biochemistry (2009) 0.95
Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae. Methods Enzymol (2006) 0.94
Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta. Nucleic Acids Res (2009) 0.94
Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase. Biochemistry (2010) 0.94
Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. J Biol Chem (2008) 0.94
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures. Nucleic Acids Res (2013) 0.93
Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases. Chem Res Toxicol (2012) 0.93
Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta. Biochemistry (2007) 0.93
Clamping the Mec1/ATR checkpoint kinase into action. Cell Cycle (2007) 0.93
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2009) 0.93
Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. J Med Chem (2009) 0.92
Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.91
Requirement for ATP by the DNA damage checkpoint clamp loader. J Biol Chem (2004) 0.91
MicroPET imaging of MCF-7 tumors in mice via unr mRNA-targeted peptide nucleic acids. Bioconjug Chem (2005) 0.91
Kinetic basis for the differing response to an oxidative lesion by a replicative and a lesion bypass DNA polymerase from Sulfolobus solfataricus. Biochemistry (2012) 0.91
Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides. J Biol Chem (2012) 0.91
Kinetic basis of sugar selection by a Y-family DNA polymerase from Sulfolobus solfataricus P2. Biochemistry (2010) 0.90
Multidomain protein solves the folding problem by multifunnel combined landscape: theoretical investigation of a Y-family DNA polymerase. J Am Chem Soc (2012) 0.90
Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis. DNA Repair (Amst) (2010) 0.90
Evidence for Watson-Crick and not Hoogsteen or wobble base pairing in the selection of nucleotides for insertion opposite pyrimidines and a thymine dimer by yeast DNA pol eta. Biochemistry (2005) 0.90
Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases. Antimicrob Agents Chemother (2010) 0.89
Elucidating the kinetic mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase B1. Biochemistry (2009) 0.89
Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase. J Mol Biol (2011) 0.89
Biochemical, structural, and physiological characterization of terminal deoxynucleotidyl transferase. Chem Rev (2006) 0.89
Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases. Biochemistry (2014) 0.88
Low fidelity bypass of O(2)-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model DNA polymerases. Chem Res Toxicol (2012) 0.88
Kinetic effect of a downstream strand and its 5'-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda. J Biol Chem (2006) 0.87
DNA lesion alters global conformational dynamics of Y-family DNA polymerase during catalysis. J Biol Chem (2012) 0.86
Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential. Biochemistry (2010) 0.86
Ability of polymerase eta and T7 DNA polymerase to bypass bulge structures. J Biol Chem (2007) 0.86
Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase η. J Biol Chem (2012) 0.85
Serial analysis of mutation spectra (SAMS): a new approach for the determination of mutation spectra of site-specific DNA damage and their sequence dependence. Nucleic Acids Res (2008) 0.84
Identification and characterization of high affinity antisense PNAs for the human unr (upstream of N-ras) mRNA which is uniquely overexpressed in MCF-7 breast cancer cells. Nucleic Acids Res (2005) 0.84
Rotational position of a 5-methylcytosine-containing cyclobutane pyrimidine dimer in a nucleosome greatly affects its deamination rate. J Biol Chem (2010) 0.83
Kinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε. Biochemistry (2013) 0.83
Role of base stacking and sequence context in the inhibition of yeast DNA polymerase eta by pyrene nucleotide. Biochemistry (2004) 0.83
Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. J Mol Biol (2009) 0.82
Native mRNA antisense-accessible sites library for the selection of antisense oligonucleotides, PNAs, and siRNAs. RNA (2010) 0.82