Published in EMBO J on May 28, 2010
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A (2012) 1.44
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23
Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. J Biol Chem (2011) 1.04
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nat Struct Mol Biol (2012) 1.02
Repair of DNA double-strand breaks following UV damage in three Sulfolobus solfataricus strains. J Bacteriol (2010) 0.93
Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV. J Am Chem Soc (2011) 0.89
Understanding DNA Repair in Hyperthermophilic Archaea: Persistent Gaps and Other Reasons to Focus on the Fork. Archaea (2015) 0.85
Roles of the Y-family DNA polymerase Dbh in accurate replication of the Sulfolobus genome at high temperature. DNA Repair (Amst) (2012) 0.81
Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase. Nucleic Acids Res (2012) 0.81
Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β. J Biol Chem (2014) 0.80
Translesion DNA Synthesis. Ecosal Plus (2012) 0.80
Identification of an unfolding intermediate for a DNA lesion bypass polymerase. Chem Res Toxicol (2012) 0.77
Translesion synthesis past guanine(C8)-thymine(N3) intrastrand cross-links catalyzed by selected A- and Y-family polymerases. Mol Biosyst (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38
Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene (2003) 10.74
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Cell (2001) 5.93
Structure, Recognition, and Processing of Cisplatin-DNA Adducts. Chem Rev (1999) 5.63
Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev (2006) 5.08
Studies with Cyanidium caldarium, an anomalously pigmented chlorophyte. Arch Mikrobiol (1959) 4.57
Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu Rev Biochem (2001) 4.47
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Nature (1995) 3.67
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science (2002) 3.06
The low barrier hydrogen bond in enzymatic catalysis. J Biol Chem (1998) 2.49
Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell (2007) 2.46
Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole. PLoS Biol (2006) 2.41
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J (2009) 2.37
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature (1999) 2.35
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability. Mol Gen Genet (1998) 2.11
Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshifts. Mol Cell (2004) 2.10
Replication of a cis-syn thymine dimer at atomic resolution. Nature (2003) 2.07
Mechanism of a genetic glissando: structural biology of indel mutations. Trends Biochem Sci (2006) 2.06
Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells (1990) 2.06
Cisplatin: from DNA damage to cancer chemotherapy. Prog Nucleic Acid Res Mol Biol (2001) 1.95
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA. Biochim Biophys Acta (1985) 1.85
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry (2000) 1.75
Occurrence and characterization of mercury resistance in the hyperthermophilic archaeon Sulfolobus solfataricus by use of gene disruption. J Bacteriol (2004) 1.70
A systematic proteomic study of seed filling in soybean. Establishment of high-resolution two-dimensional reference maps, expression profiles, and an interactive proteome database. Plant Physiol (2005) 1.67
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Proc Natl Acad Sci U S A (2004) 1.66
Targeted disruption of the alpha-amylase gene in the hyperthermophilic archaeon Sulfolobus solfataricus. J Bacteriol (2003) 1.60
A role for polymerase eta in the cellular tolerance to cisplatin-induced damage. Cancer Res (2005) 1.58
X-ray structure of the major adduct of the anticancer drug cisplatin with DNA: cis-[Pt(NH3)2(d(pGpG))]. Science (1985) 1.57
Replication of damaged DNA in mammalian cells: new solutions to an old problem. Mutat Res (2002) 1.42
Roles of DnaK and RpoS in starvation-induced thermotolerance of Escherichia coli. J Bacteriol (1998) 1.42
Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res (1994) 1.41
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res (1998) 1.39
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. EMBO J (2009) 1.33
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc Natl Acad Sci U S A (2007) 1.33
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Proc Natl Acad Sci U S A (1995) 1.33
Molecular characterization of the alpha-glucosidase gene (malA) from the hyperthermophilic archaeon Sulfolobus solfataricus. J Bacteriol (1998) 1.33
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure (2006) 1.31
Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells. Cancer Res (1987) 1.29
Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4. J Mol Biol (2008) 1.29
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc Natl Acad Sci U S A (1998) 1.24
The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta. J Biol Chem (2000) 1.20
Cisplatin damage: are DNA repair proteins saviors or traitors to the cell? Chembiochem (2005) 1.18
Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents. Oncogene (2001) 1.15
Site selectivity of platinum anticancer therapeutics. Nat Chem Biol (2007) 1.14
In vitro bypass replication of the cisplatin-d(GpG) lesion by calf thymus DNA polymerase beta and human immunodeficiency virus type I reverse transcriptase is highly mutagenic. J Biol Chem (1996) 1.13
"Platinum-pyrimidine blues" and related complexes: a new class of potent antitumor agents. Cancer Chemother Rep (1975) 1.08
Extragenic pleiotropic mutations that repress glycosyl hydrolase expression in the hyperthermophilic archaeon Sulfolobus solfataricus. Genetics (1999) 1.08
Single d(GpG)/cis-diammineplatinum(II) adduct-induced inhibition of DNA polymerization. Biochemistry (1999) 1.07
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.97
Molecular structure of the complex formed between the anticancer drug cisplatin and d(pGpG): C222(1) crystal form. J Biomol Struct Dyn (1990) 0.86
Role of DNA replication in carrier-ligand-specific resistance to platinum compounds in L1210 cells. Carcinogenesis (1991) 0.86
Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. DNA Repair (Amst) (2002) 0.86
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Occurrence and characterization of mercury resistance in the hyperthermophilic archaeon Sulfolobus solfataricus by use of gene disruption. J Bacteriol (2004) 1.70
Targeted disruption of the alpha-amylase gene in the hyperthermophilic archaeon Sulfolobus solfataricus. J Bacteriol (2003) 1.60
Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine. Proc Natl Acad Sci U S A (2010) 1.57
Pre-steady-state kinetic studies of the fidelity of Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.57
Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry (2011) 1.56
Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry (2004) 1.52
Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction. Basic Res Cardiol (2008) 1.52
A freestanding proofreading domain is required for protein synthesis quality control in Archaea. Proc Natl Acad Sci U S A (2004) 1.52
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication. J Biol Chem (2004) 1.48
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet (2012) 1.42
DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli. Genetics (2009) 1.40
Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium. Toxicol Sci (2008) 1.40
Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis. Am J Pathol (2012) 1.38
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. EMBO J (2009) 1.33
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc Natl Acad Sci U S A (2007) 1.33
Genotypes and characteristics of clustering and drug susceptibility of Mycobacterium tuberculosis isolates collected in Heilongjiang Province, China. J Clin Microbiol (2011) 1.30
Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal. Mol Microbiol (2008) 1.29
Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4. J Mol Biol (2008) 1.29
Engineering thermoacidophilic archaea using linear DNA recombination. Methods Mol Biol (2011) 1.28
Stability of mRNA in the hyperthermophilic archaeon Sulfolobus solfataricus. RNA (2002) 1.25
Pre-steady-state kinetic studies of the fidelity and mechanism of polymerization catalyzed by truncated human DNA polymerase lambda. Biochemistry (2004) 1.25
Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass. DNA Repair (Amst) (2002) 1.24
Mechanism of abasic lesion bypass catalyzed by a Y-family DNA polymerase. J Biol Chem (2007) 1.23
Characterization of a CD4-independent clinical HIV-1 that can efficiently infect human hepatocytes through chemokine (C-X-C motif) receptor 4. AIDS (2008) 1.22
A novel mechanism of sugar selection utilized by a human X-family DNA polymerase. J Mol Biol (2009) 1.20
Single-turnover kinetic analysis of the mutagenic potential of 8-oxo-7,8-dihydro-2'-deoxyguanosine during gap-filling synthesis catalyzed by human DNA polymerases lambda and beta. J Mol Biol (2007) 1.14
Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA. Mol Microbiol (2008) 1.14
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. J Mol Biol (2006) 1.14
Regulation of mercury resistance in the crenarchaeote Sulfolobus solfataricus. J Bacteriol (2006) 1.08
Sloppy bypass of an abasic lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2007) 1.07
Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31. J Mol Biol (2006) 1.07
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep (2003) 1.06
Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int (2004) 1.06
Up-regulation of the fidelity of human DNA polymerase lambda by its non-enzymatic proline-rich domain. J Biol Chem (2006) 1.06
Flagellar motility and structure in the hyperthermoacidophilic archaeon Sulfolobus solfataricus. J Bacteriol (2007) 1.06
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J (2013) 1.05
Global conformational dynamics of a Y-family DNA polymerase during catalysis. PLoS Biol (2009) 1.05
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress. PLoS One (2009) 1.05
Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. Cancer Res (2007) 1.05
Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc Natl Acad Sci U S A (2011) 1.03
Distribution and genetic characterizations of Cryptosporidium spp. in pre-weaned dairy calves in Northeastern China's Heilongjiang Province. PLoS One (2013) 1.02
Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus. Nucleic Acids Res (2003) 1.02
Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. Mutagenesis (2009) 1.01
In vivo transgenic mutation assays. Mutat Res (2003) 1.01
Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu. Biochemistry (2004) 1.00
Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. J Mol Biol (2008) 1.00
Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli. J Bacteriol (2006) 0.99
Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2. Plant J (2008) 0.99
Surface-enhanced Raman scattering of patterned copper nanostructure electrolessly plated on arrayed nanoporous silicon pillars. J Phys Condens Matter (2010) 0.98
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.97
Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases. Nucleic Acids Res (2010) 0.96
Metal resistance and lithoautotrophy in the extreme thermoacidophile Metallosphaera sedula. J Bacteriol (2012) 0.96
Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection. Proc Natl Acad Sci U S A (2010) 0.96
VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (2011) 0.96
Polymerization fidelity of a replicative DNA polymerase from the hyperthermophilic archaeon Sulfolobus solfataricus P2. Biochemistry (2009) 0.95
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate. Mol Carcinog (2005) 0.95
Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening. Acta Crystallogr D Biol Crystallogr (2008) 0.95
Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase. Biochemistry (2010) 0.94
Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. J Biol Chem (2008) 0.94
Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases. Chem Res Toxicol (2012) 0.93
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2009) 0.93
Analysis of human immunodeficiency virus type 1 nef gene sequences among inmates from prisons in China. AIDS Res Hum Retroviruses (2009) 0.93
MiR-122 modulates type I interferon expression through blocking suppressor of cytokine signaling 1. Int J Biochem Cell Biol (2013) 0.93
The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa. Biochemistry (2009) 0.93
DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: their efficiency and template base preference. Mutat Res (2010) 0.92
The role of cis-acting sequences governing catabolite repression control of lacS expression in the archaeon Sulfolobus solfataricus. Genetics (2004) 0.92
Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A. Toxicol Sci (2011) 0.92
Kinetic basis for the differing response to an oxidative lesion by a replicative and a lesion bypass DNA polymerase from Sulfolobus solfataricus. Biochemistry (2012) 0.91
Cell membrane is impaired, accompanied by enhanced type III secretion system expression in Yersinia pestis deficient in RovA regulator. PLoS One (2010) 0.91
Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase. Nucleic Acids Res (2008) 0.91
Large-scale cultivation of acidophilic hyperthermophiles for recovery of secreted proteins. Appl Environ Microbiol (2003) 0.91
Subtype and sequence analysis of HIV-1 strains in Heilongjiang Province. Chin Med J (Engl) (2007) 0.91
Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides. J Biol Chem (2012) 0.91
Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides. Nucleic Acids Res (2009) 0.91
Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex. Genes Cells (2010) 0.90
Kinetic basis of sugar selection by a Y-family DNA polymerase from Sulfolobus solfataricus P2. Biochemistry (2010) 0.90
A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China. PLoS One (2012) 0.90
Prevalence and distribution of Cryptosporidium spp. in dairy cattle in Heilongjiang Province, China. Parasitol Res (2009) 0.90
Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis. DNA Repair (Amst) (2010) 0.90
Nitro-oleic acid protects against adriamycin-induced nephropathy in mice. Am J Physiol Renal Physiol (2013) 0.90
Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems. Part Fibre Toxicol (2009) 0.90
Multidomain protein solves the folding problem by multifunnel combined landscape: theoretical investigation of a Y-family DNA polymerase. J Am Chem Soc (2012) 0.90
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Carcinogenesis (2005) 0.90
Molecular identification and distribution of Cryptosporidium and Giardia duodenalis in raw urban wastewater in Harbin, China. Parasitol Res (2011) 0.89
Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases. Antimicrob Agents Chemother (2010) 0.89
Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase. J Mol Biol (2011) 0.89
Biochemical, structural, and physiological characterization of terminal deoxynucleotidyl transferase. Chem Rev (2006) 0.89
Elucidating the kinetic mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase B1. Biochemistry (2009) 0.89
Alicyclobacillus vulcanalis sp. nov., a thermophilic, acidophilic bacterium isolated from Coso Hot Springs, California, USA. Int J Syst Evol Microbiol (2004) 0.89
Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli. J Bacteriol (2009) 0.89