Published in Proc Natl Acad Sci U S A on December 12, 2011
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
miR-34: from bench to bedside. Oncotarget (2014) 1.59
Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet (2012) 1.59
GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle (2013) 1.32
MicroRNA-34a: a potential therapeutic target in human cancer. Cell Death Dis (2014) 1.32
MicroRNA-34a upregulation during seizure-induced neuronal death. Cell Death Dis (2012) 1.20
MicroRNA regulation of the synaptic plasticity-related gene Arc. PLoS One (2012) 1.07
MicroRNAs and p63 in epithelial stemness. Cell Death Differ (2014) 1.03
MicroRNAs tune cerebral cortical neurogenesis. Cell Death Differ (2012) 0.99
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry (2015) 0.99
Insights on the functional impact of microRNAs present in autism-associated copy number variants. PLoS One (2013) 0.97
p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene. Cell Death Differ (2013) 0.97
TREM2 signaling, miRNA-34a and the extinction of phagocytosis. Front Cell Neurosci (2013) 0.94
MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review. Front Mol Neurosci (2013) 0.93
Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction. J Clin Invest (2014) 0.92
Proteomic profiling of cardiac tissue by isolation of nuclei tagged in specific cell types (INTACT). Development (2014) 0.92
MicroRNAs in the pathophysiology and treatment of status epilepticus. Front Mol Neurosci (2013) 0.91
TAp73 promotes anti-senescence-anabolism not proliferation. Aging (Albany NY) (2014) 0.91
Alternative polyadenylation and miR-34 family members regulate tau expression. J Neurochem (2013) 0.91
The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle (2012) 0.90
TAp73 promotes anabolism. Oncotarget (2014) 0.89
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system. Cell Cycle (2015) 0.89
miR-34 is maternally inherited in Drosophila melanogaster and Danio rerio. Nucleic Acids Res (2013) 0.89
TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor. Proc Natl Acad Sci U S A (2013) 0.88
Metabolic reprogramming during neuronal differentiation. Cell Death Differ (2016) 0.87
miRNA regulons associated with synaptic function. PLoS One (2012) 0.86
Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities. Oncotarget (2014) 0.86
MicroRNA regulation and dysregulation in epilepsy. Front Cell Neurosci (2013) 0.85
Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update. Front Aging Neurosci (2014) 0.85
Tissue-specific expression of p73 C-terminal isoforms in mice. Cell Cycle (2012) 0.84
Rapamycin regulates biochemical metabolites. Cell Cycle (2013) 0.84
Molecular dynamics of the full-length p53 monomer. Cell Cycle (2013) 0.82
JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. Cell Death Dis (2014) 0.81
P73 and age-related diseases: is there any link with Parkinson Disease? Aging (Albany NY) (2012) 0.81
Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation. Front Mol Neurosci (2015) 0.81
p53 prevents neurodegeneration by regulating synaptic genes. Proc Natl Acad Sci U S A (2014) 0.81
Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish. Neurotoxicol Teratol (2013) 0.80
Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity. Brain Res (2016) 0.79
miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes. Cell Death Dis (2015) 0.79
Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders. Mol Brain (2015) 0.79
MicroRNAs and Molecular Mechanisms of Neurodegeneration. Genes (Basel) (2013) 0.78
Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model. Front Aging Neurosci (2013) 0.78
Resveratrol inhibits dysfunction of dendritic cells from chronic obstructive pulmonary disease patients through promoting miR-34. Int J Clin Exp Pathol (2015) 0.78
Molecule of the month: miRNA and proteins in Alzheimer's disease. Bioinformation (2013) 0.77
TAp73 transcriptionally represses BNIP3 expression. Cell Cycle (2015) 0.77
Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells. Cell Mol Neurobiol (2014) 0.77
Ultraconserved long non-coding RNA uc.63 in breast cancer. Oncotarget (2016) 0.76
Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a. Mol Cell Biol (2015) 0.76
p73 regulates basal and starvation-induced liver metabolism in vivo. Oncotarget (2015) 0.76
Tumor suppressors control ULBP2, an innate surface ligand of the lymphocyte immune receptor NKG2D. Oncoimmunology (2012) 0.76
Metabolic pathways regulated by TAp73 in response to oxidative stress. Oncotarget (2016) 0.76
Tumor suppressive pathways in the control of neurogenesis. Cell Mol Life Sci (2012) 0.76
Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin? Aging (Albany NY) (2012) 0.76
Fluorescence imaging of in vivo miR-124a-induced neurogenesis of neuronal progenitor cells using neuron-specific reporters. EJNMMI Res (2016) 0.75
RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense. J Biol Chem (2016) 0.75
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance. Cell Cycle (2015) 0.75
Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells. Cell Death Dis (2016) 0.75
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Sci Rep (2017) 0.75
Alternative mechanisms of miR-34a regulation in cancer. Cell Death Dis (2017) 0.75
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell (2007) 9.51
p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol (2007) 6.87
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55
The miR-34 family in cancer and apoptosis. Cell Death Differ (2009) 5.92
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature (2000) 5.83
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A (2007) 5.50
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature (1985) 3.50
The MYCN oncogene is a direct target of miR-34a. Oncogene (2008) 2.80
Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J (2009) 2.65
Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ (2001) 2.40
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ (2005) 2.25
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06
Synaptotagmin I and II are present in distinct subsets of central synapses. J Comp Neurol (2007) 1.73
miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull (2009) 1.66
p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ (2010) 1.60
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Curr Biol (2010) 1.58
Genome-wide gene expression profiles of the developing mouse hippocampus. Proc Natl Acad Sci U S A (2001) 1.55
p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron (2008) 1.42
Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem (2000) 1.35
p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun (2010) 1.25
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53. Cell Death Dis (2010) 1.20
p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. J Neurosci (2009) 1.19
Roles for p53 and p73 during oligodendrocyte development. Development (2004) 1.18
TAp73 is a downstream target of p53 in controlling the cellular defense against stress. J Biol Chem (2007) 1.01
Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS. J Neurosci (1997) 1.00
MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells. Int J Oncol (2009) 0.99
The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain. Neuropathol Appl Neurobiol (2004) 0.90
TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism. Neurosci Lett (2006) 0.88
Syntaxin 1A is required for normal in utero development. Biochem Biophys Res Commun (2008) 0.86
Association study between P53 and P73 gene polymorphisms and the sporadic late-onset form of Alzheimer's disease. J Neural Transm (Vienna) (2009) 0.82
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol (2003) 9.07
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science (2011) 5.87
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol (2007) 5.83
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med (2010) 5.68
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature (2005) 5.37
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (2002) 4.56
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe (2009) 4.20
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity (2003) 4.07
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2006) 3.85
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A (2005) 3.83
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med (2006) 3.78
Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer (2004) 3.76
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61
On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet (2002) 3.57
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41
Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell (2011) 3.36
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell (2008) 3.35
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell (2002) 3.29
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol (2003) 3.18
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell (2005) 3.12
Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology (2015) 3.10
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol (2003) 3.07
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97
Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol (2008) 2.95
The role of cytokines in classical Hodgkin lymphoma. Blood (2002) 2.86
Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10). Am J Respir Crit Care Med (2005) 2.86
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A (2004) 2.74
Metabolic targeting as an anticancer strategy: dawn of a new era? Sci STKE (2007) 2.71
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity (2003) 2.63
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell (2005) 2.63
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci U S A (2002) 2.61
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
Functional regulation of p73 and p63: development and cancer. Trends Biochem Sci (2003) 2.29
Mitochondrial cell death effectors. Curr Opin Cell Biol (2009) 2.29
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med (2009) 2.26
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood (2012) 2.23
Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov (2013) 2.22
The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol (2003) 2.17
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14
The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13
Toxicology: a risky business. Nature (2002) 2.10
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell (2007) 2.09
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06
Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med (2009) 2.03
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem (2002) 2.03
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A (2011) 1.98
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A (2006) 1.96
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity (2011) 1.96
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90