Published in Sci Transl Med on September 01, 2010
Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res (2011) 2.94
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Sci Transl Med (2014) 2.50
High-resolution description of antibody heavy-chain repertoires in humans. PLoS One (2011) 2.36
Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol (2013) 2.19
Rep-Seq: uncovering the immunological repertoire through next-generation sequencing. Immunology (2012) 1.99
Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood (2013) 1.95
Prize-based contests can provide solutions to computational biology problems. Nat Biotechnol (2013) 1.95
Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics (2011) 1.87
Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med (2013) 1.86
IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nat Commun (2013) 1.71
Ultra-sensitive detection of rare T cell clones. J Immunol Methods (2011) 1.64
CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. Blood (2015) 1.63
Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A (2014) 1.63
Statistical inference of the generation probability of T-cell receptors from sequence repertoires. Proc Natl Acad Sci U S A (2012) 1.59
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A (2012) 1.41
Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood (2011) 1.39
Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment. Sci Transl Med (2011) 1.36
The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol (2013) 1.22
Chromatin conformation governs T-cell receptor Jβ gene segment usage. Proc Natl Acad Sci U S A (2012) 1.22
Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells. Nat Biotechnol (2014) 1.22
Immune aging and autoimmunity. Cell Mol Life Sci (2012) 1.19
VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires. PLoS Comput Biol (2015) 1.17
Sequence analysis of T-cell repertoires in health and disease. Genome Med (2013) 1.17
Unifying immunology with informatics and multiscale biology. Nat Immunol (2014) 1.15
Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire. Front Immunol (2013) 1.14
Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing. Proc Natl Acad Sci U S A (2014) 1.14
T cells and their eons-old obsession with MHC. Immunol Rev (2012) 1.13
BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Oncoimmunology (2013) 1.13
Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling. Front Immunol (2013) 1.12
Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS). Oncoimmunology (2015) 1.11
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age. Proc Natl Acad Sci U S A (2012) 1.11
Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas. J Pathol (2013) 1.09
Determinants of public T cell responses. Cell Res (2012) 1.09
T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity. Genome Res (2014) 1.06
Mother and child T cell receptor repertoires: deep profiling study. Front Immunol (2013) 1.06
αβ T cell receptors as predictors of health and disease. Cell Mol Immunol (2015) 1.01
Emerging concepts in tissue-resident T cells: lessons from humans. Trends Immunol (2015) 0.99
A new approach to simultaneously quantify both TCR α- and β-chain diversity after adoptive immunotherapy. Clin Cancer Res (2012) 0.98
Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function. Immunol Rev (2012) 0.98
Quantifying selection in immune receptor repertoires. Proc Natl Acad Sci U S A (2014) 0.96
Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity (2014) 0.92
Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach. Philos Trans R Soc Lond B Biol Sci (2015) 0.91
Huge Overlap of Individual TCR Beta Repertoires. Front Immunol (2013) 0.90
Applications of next-generation sequencing to blood and marrow transplantation. Biol Blood Marrow Transplant (2012) 0.89
High-resolution analysis of the human T-cell receptor repertoire. Nat Commun (2015) 0.88
Next generation sequencing: new tools in immunology and hematology. Blood Res (2013) 0.88
A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes. Protein Sci (2013) 0.87
Unbiased analysis of TCRα/β chains at the single-cell level in human CD8+ T-cell subsets. PLoS One (2012) 0.86
IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. Bioinformatics (2015) 0.86
A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status. Genome Med (2015) 0.86
Engineering improved T cell receptors using an alanine-scan guided T cell display selection system. J Immunol Methods (2013) 0.85
High-throughput sequencing of B- and T-lymphocyte antigen receptors in hematology. Blood (2013) 0.85
Interrogating the relationship between naïve and immune antiviral T cell repertoires. Curr Opin Virol (2013) 0.85
Specific roles of each TCR hemichain in generating functional chain-centric TCR. J Immunol (2015) 0.84
Current status and recent advances of next generation sequencing techniques in immunological repertoire. Genes Immun (2016) 0.84
Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells. Sci Immunol (2017) 0.84
A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging. Immunology (2014) 0.83
MHC-derived allopeptide activates TCR-biased CD8+ Tregs and suppresses organ rejection. J Clin Invest (2014) 0.83
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction. PLoS One (2015) 0.82
Genetic variation in MHC proteins is associated with T cell receptor expression biases. Nat Genet (2016) 0.82
CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing. Nat Commun (2016) 0.81
RTCR: a pipeline for complete and accurate recovery of T cell repertoires from high throughput sequencing data. Bioinformatics (2016) 0.81
Donor Unrestricted T Cells: A Shared Human T Cell Response. J Immunol (2015) 0.81
Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains. Protein Cell (2014) 0.81
Palindromic nucleotide analysis in human T cell receptor rearrangements. PLoS One (2012) 0.81
A Public Database of Memory and Naive B-Cell Receptor Sequences. PLoS One (2016) 0.80
Cross-reactivity of T cells and its role in the immune system. Crit Rev Immunol (2012) 0.80
Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients After HLA-Matched Allogeneic Stem Cell Transplantation. Am J Transplant (2015) 0.79
Detecting and monitoring lymphoma with high-throughput sequencing. Oncotarget (2011) 0.79
Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis. Oncoimmunology (2015) 0.79
Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. J Immunol (2014) 0.79
Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8(+) T Cells In Vivo. Sci Immunol (2017) 0.78
Biomarkers for glioma immunotherapy: the next generation. J Neurooncol (2015) 0.78
Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc Natl Acad Sci U S A (2016) 0.78
Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing. PLoS One (2015) 0.78
Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire. PLoS One (2016) 0.77
Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response. Front Immunol (2015) 0.77
Indoctrinating T cells to attack pathogens through homeschooling. Trends Immunol (2015) 0.77
Preferential Use of Public TCR during Autoimmune Encephalomyelitis. J Immunol (2016) 0.77
Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide. JCI Insight (2016) 0.76
Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves. Elife (2016) 0.76
The immune system as a biomonitor: explorations in innate and adaptive immunity. Interface Focus (2013) 0.76
Successful and Maladaptive T Cell Aging. Immunity (2017) 0.75
Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient. BMC Cancer (2016) 0.75
Integrative network modeling approaches to personalized cancer medicine. Per Med (2015) 0.75
Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use. J Mol Diagn (2016) 0.75
Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients. Sci Rep (2016) 0.75
High Throughput Sequencing of T Cell Antigen Receptors Reveals a Conserved TCR Repertoire. Medicine (Baltimore) (2016) 0.75
Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease. Exp Biol Med (Maywood) (2016) 0.75
On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments. J R Soc Interface (2016) 0.75
Autoimmune susceptibility imposed by public TCRβ chains. Sci Rep (2016) 0.75
Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization. Front Immunol (2017) 0.75
High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia. Clin Immunol (2015) 0.75
TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol (2015) 0.75
Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients. Front Immunol (2016) 0.75
Challenges and promise for the development of human immune monitoring. Rambam Maimonides Med J (2012) 0.75
Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire. Nat Genet (2017) 0.75
Characterization of the T-cell receptor beta chain repertoire in tumor-infiltrating lymphocytes. Cancer Med (2016) 0.75
T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas. Cancer (2017) 0.75
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. PLoS Comput Biol (2017) 0.75
T-cell antigen receptor genes and T-cell recognition. Nature (1988) 16.77
How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol (2006) 7.57
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood (2009) 7.00
IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs. Bioinformatics (2004) 4.11
The molecular basis for public T-cell responses? Nat Rev Immunol (2008) 3.32
Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J Exp Med (1994) 2.47
Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature (1986) 2.33
Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. J Exp Med (2001) 1.86
TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV. J Immunol (2008) 1.70
Efficient immune responses in mice lacking N-region diversity. Eur J Immunol (1995) 1.22
Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol (2004) 7.11
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood (2008) 7.01
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood (2009) 7.00
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91
Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA (2006) 3.26
Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood (2009) 3.05
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood (2012) 2.97
Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer (2004) 2.65
A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity (2009) 2.64
Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice. Blood (2010) 2.61
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood (2010) 2.59
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood (2002) 2.48
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood (2010) 2.45
Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD. Blood (2009) 2.44
Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet (2011) 2.35
CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. Blood (2013) 2.22
Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell (2006) 2.20
An antigen produced by splicing of noncontiguous peptides in the reverse order. Science (2006) 2.18
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood (2011) 2.15
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet (2011) 2.13
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation (2013) 2.06
Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood (2009) 2.00
Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants. Blood (2003) 1.93
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92
Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study. Hum Genet (2007) 1.91
Influence of immunosuppressive treatment on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation. Blood (2011) 1.90
Evaluation of published single nucleotide polymorphisms associated with acute GVHD. Blood (2012) 1.88
Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells. Blood (2010) 1.88
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin Cancer Res (2013) 1.85
Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus. J Clin Invest (2002) 1.79
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. J Clin Invest (2016) 1.75
HapMap scanning of novel human minor histocompatibility antigens. Blood (2008) 1.75
Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia. Clin Cancer Res (2009) 1.74
Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy. Hum Gene Ther (2007) 1.70
Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood (2013) 1.69
Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet (2006) 1.66
Ultra-sensitive detection of rare T cell clones. J Immunol Methods (2011) 1.64
Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.62
Induction of cytotoxic T-lymphocyte responses to enhanced green and yellow fluorescent proteins after myeloablative conditioning. Blood (2003) 1.61
A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. J Exp Med (2003) 1.61
High-throughput genotyping of intermediate-size structural variation. Hum Mol Genet (2006) 1.61
Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 1.58
Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. J Exp Med (2003) 1.55
Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Blood (2011) 1.54
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale. J Immunother (2012) 1.47
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1. Nat Immunol (2011) 1.46
Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens. Clin Cancer Res (2004) 1.42
Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection. Blood (2004) 1.42
Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. Nat Genet (2009) 1.40
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biol Blood Marrow Transplant (2010) 1.38
Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells. Cancer Res (2009) 1.37
Adoptive transfer of virus-specific and tumor-specific T cell immunity. Curr Opin Immunol (2009) 1.36
Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment. Sci Transl Med (2011) 1.36
Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells. Proc Natl Acad Sci U S A (2005) 1.36
Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells. Immunol Rev (2014) 1.33
SNPit: a federated data integration system for the purpose of functional SNP annotation. Comput Methods Programs Biomed (2009) 1.33
Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation. Arterioscler Thromb Vasc Biol (2008) 1.32
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring) (2013) 1.28
Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet (2013) 1.27
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol (2011) 1.26
Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet (2013) 1.24
Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells. Blood (2002) 1.24
Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein. J Immunol (2003) 1.21
C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. Clin Cancer Res (2008) 1.20
HLA engineering of human pluripotent stem cells. Mol Ther (2013) 1.19
Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J Exp Med (2009) 1.19
Enhanced transgene expression in quiescent and activated human CD8+ T cells. Hum Gene Ther (2004) 1.19
The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. Blood (2006) 1.17