The effects of a DTNBP1 gene variant on attention networks: an fMRI study.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 2949706)

Published in Behav Brain Funct on September 16, 2010

Authors

Markus Thimm1, Axel Krug, Thilo Kellermann, Valentin Markov, Sören Krach, Andreas Jansen, Klaus Zerres, Thomas Eggermann, Tony Stöcker, N Jon Shah, Markus M Nöthen, Marcella Rietschel, Tilo Kircher

Author Affiliations

1: Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. mthimm@ukaachen.de

Articles cited by this

The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia (1971) 86.03

Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci (2000) 18.84

The attention system of the human brain. Annu Rev Neurosci (1990) 15.51

Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science (2000) 12.09

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry (2005) 9.23

Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature (1999) 8.38

Testing the efficiency and independence of attentional networks. J Cogn Neurosci (2002) 8.03

Increased activity in human visual cortex during directed attention in the absence of visual stimulation. Neuron (1999) 6.08

Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci (2000) 5.94

The activation of attentional networks. Neuroimage (2005) 5.61

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet (2002) 4.03

A PET study of visuospatial attention. J Neurosci (1993) 3.55

Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull (2005) 3.36

Localization of a human system for sustained attention by positron emission tomography. Nature (1991) 3.35

Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry (2001) 3.19

Cognitive and brain consequences of conflict. Neuroimage (2003) 3.04

Asymmetries in hemispheric control of attention in schizophrenia. Arch Gen Psychiatry (1988) 2.98

Analysis of a large fMRI cohort: Statistical and methodological issues for group analyses. Neuroimage (2007) 2.75

The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol (2005) 2.67

Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res (2004) 2.61

The contribution of the anterior cingulate cortex to executive processes in cognition. Rev Neurosci (1999) 2.57

Emerging principles of altered neural circuitry in schizophrenia. Brain Res Brain Res Rev (2000) 2.51

Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance. Am J Psychiatry (1997) 2.37

Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull (1994) 2.18

Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci U S A (2003) 2.09

Assessing the molecular genetics of attention networks. BMC Neurosci (2002) 2.02

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet (2004) 1.95

On the functional neuroanatomy of intrinsic and phasic alertness. Neuroimage (2001) 1.93

Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage (1999) 1.83

Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry (2004) 1.82

Functional anatomy of intrinsic alertness: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia (1999) 1.76

Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet (2006) 1.61

The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry (2004) 1.61

Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet (2004) 1.45

Neuropsychological correlates of diffusion tensor imaging in schizophrenia. Neuropsychology (2004) 1.43

Local infusion of scopolamine into intraparietal cortex slows covert orienting in rhesus monkeys. J Neurophysiol (2000) 1.36

Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry (2007) 1.32

Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Med Genet (2000) 1.27

Imaging genetic liability to schizophrenia: systematic review of FMRI studies of patients' nonpsychotic relatives. Schizophr Bull (2008) 1.24

Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophr Bull (2005) 1.24

Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. Neuropsychologia (2006) 1.21

DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res (2006) 1.20

Attentional networks and cingulum bundle in chronic schizophrenia. Schizophr Res (2006) 1.18

Selective impairment of attentional networks of orienting and executive control in schizophrenia. Schizophr Res (2005) 1.17

Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry (1991) 1.16

Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour. Neurosci Biobehav Rev (2006) 1.14

DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals. Neuropsychopharmacology (2006) 1.06

Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct (2007) 1.06

Variation in the dysbindin gene and normal cognitive function in three independent population samples. Genes Brain Behav (2008) 1.03

Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biol Psychiatry (2009) 1.00

Prefrontal dysfunction in first-degree relatives of schizophrenia patients during a Stroop task. Neuropsychopharmacology (2008) 0.99

Functional magnetic resonance imaging (fMRI) of attention processes in presumed obligate carriers of schizophrenia: preliminary findings. Ann Gen Psychiatry (2008) 0.97

A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry (2010) 0.92

Dysbindin-1 and schizophrenia: from genetics to neuropathology. J Clin Invest (2004) 0.90

Orienting of attention in unmedicated patients with schizophrenia, prodromal subjects and healthy relatives. Schizophr Res (2007) 0.89

Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals. Hum Brain Mapp (2009) 0.88

Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals. Hum Brain Mapp (2010) 0.88

Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals. Neuroimage (2008) 0.87

A putative high risk diplotype of the G72 gene is in healthy individuals associated with better performance in working memory functions and altered brain activity in the medial temporal lobe. Neuroimage (2009) 0.87

Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci (2009) 0.86

Attentional network task performance in patients with schizophrenia-spectrum disorders: evidence of a specific deficit. Schizophr Res (2006) 0.86

Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients. Biol Psychiatry (2006) 0.86

Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals. Neuroimage (2009) 0.85

Effects of irregular preparatory intervals on reaction time in schizophrenia. J Abnorm Soc Psychol (1963) 0.83

Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects. Psychol Med (2009) 0.83

Genes and neuroimaging: advances in psychiatric research. Neurodegener Dis (2008) 0.81

Dysbindin modulates brain function during visual processing in children. Neuroimage (2009) 0.81

The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency. Eur Arch Psychiatry Clin Neurosci (2009) 0.80

Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. Neuropsychobiology (2009) 0.80

The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval. Hum Brain Mapp (2010) 0.79

Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects. BMC Psychiatry (2009) 0.78

Articles by these authors

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52

Common variants conferring risk of schizophrenia. Nature (2009) 10.37

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med (2002) 6.94

A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34

Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13

City living and urban upbringing affect neural social stress processing in humans. Nature (2011) 5.46

A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A (2010) 4.94

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med (2012) 4.90

Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97

Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet (2009) 3.58

Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell (2012) 3.52

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet (2002) 3.21

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21

Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08

High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron (2011) 3.08

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02

Genetic associations with valvular calcification and aortic stenosis. N Engl J Med (2013) 3.02

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet (2008) 3.00

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nat Genet (2009) 2.93

EASE: Examination of Anomalous Self-Experience. Psychopathology (2005) 2.89

Neural mechanisms of a genome-wide supported psychosis variant. Science (2009) 2.88

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population. Genome Res (2003) 2.75

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74

Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet (2011) 2.71

Dissecting the phenotype in genome-wide association studies of psychiatric illness. Br J Psychiatry (2009) 2.65

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet (2010) 2.46

Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry (2010) 2.41

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet (2005) 2.38

Human fear conditioning and extinction in neuroimaging: a systematic review. PLoS One (2009) 2.37

Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Hum Mol Genet (2003) 2.27

Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet (2011) 2.21

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet (2012) 2.15

Being with virtual others: Neural correlates of social interaction. Neuropsychologia (2005) 2.14

Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry (2010) 2.07

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet (2005) 2.04

Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome. Hum Mutat (2008) 2.03

The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron (2011) 2.02

Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample. Arch Gen Psychiatry (2007) 2.02

Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet (2002) 1.99

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res (2010) 1.98

Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci (2012) 1.98

Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatry (2010) 1.95

Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness. Am J Psychiatry (2011) 1.94

Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet (2005) 1.94

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90

Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia. Hum Brain Mapp (2011) 1.89

Minds made for sharing: initiating joint attention recruits reward-related neurocircuitry. J Cogn Neurosci (2010) 1.89

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet (2011) 1.88

Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry (2010) 1.85

Gender differences in brain networks supporting empathy. Neuroimage (2008) 1.84

Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology (2013) 1.83

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet (2013) 1.83

Transient, recurrent, white matter lesions in X-linked Charcot-Marie-Tooth disease with novel connexin 32 mutation. Arch Neurol (2003) 1.81

Susceptibility variants for male-pattern baldness on chromosome 20p11. Nat Genet (2008) 1.80

Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease. Am J Hum Genet (2006) 1.78

Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med (2007) 1.77

Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. Am J Hum Genet (2003) 1.72

Anticipation of monetary and social reward differently activates mesolimbic brain structures in men and women. Soc Cogn Affect Neurosci (2009) 1.72

Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. Am J Psychiatry (2013) 1.71

Effect of cognitive-behavioral therapy on neural correlates of fear conditioning in panic disorder. Biol Psychiatry (2012) 1.70

Lower ventral striatal activation during reward anticipation in adolescent smokers. Am J Psychiatry (2011) 1.70