Published in Curr Opin Genet Dev on September 16, 2010
Hierarchies of NF-κB target-gene regulation. Nat Immunol (2011) 1.71
Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells. PLoS Comput Biol (2012) 1.00
The Many Alternative Faces of Macrophage Activation. Front Immunol (2015) 0.98
Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening. PLoS One (2012) 0.90
Deep Learning Automates the Quantitative Analysis of Individual Cells in Live-Cell Imaging Experiments. PLoS Comput Biol (2016) 0.89
Single-cell and population NF-κB dynamic responses depend on lipopolysaccharide preparation. PLoS One (2013) 0.88
Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses. Front Microbiol (2015) 0.85
High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep (2016) 0.84
Observing single cell NF-κB dynamics under stimulant concentration gradient. Anal Chem (2012) 0.82
Live cell imaging reveals marked variability in myoblast proliferation and fate. Skelet Muscle (2013) 0.80
Light microscopy applications in systems biology: opportunities and challenges. Cell Commun Signal (2013) 0.80
Recent advances in single-cell studies of gene regulation. Curr Opin Biotechnol (2011) 0.78
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Bacterial persistence as a phenotypic switch. Science (2004) 15.80
An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (1996) 13.87
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene (1999) 13.46
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell (2006) 7.07
Circuitry of nuclear factor kappaB signaling. Immunol Rev (2006) 6.49
NF-kappaB and the immune response. Oncogene (2006) 5.62
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) 5.43
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science (2005) 4.83
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14
Visualization of image data from cells to organisms. Nat Methods (2010) 3.66
Cellular heterogeneity: do differences make a difference? Cell (2010) 3.57
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature (2008) 3.32
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc (2007) 3.31
Versatile, fully automated, microfluidic cell culture system. Anal Chem (2007) 3.19
Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature (2010) 3.06
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry. Nat Biotechnol (2002) 2.43
A global analysis of cross-talk in a mammalian cellular signalling network. Nat Cell Biol (2006) 2.39
Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene (2006) 2.33
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91
Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol Syst Biol (2006) 1.90
The type III secretion effector NleE inhibits NF-kappaB activation. PLoS Pathog (2010) 1.79
Protein dynamics in drug combinations: a linear superposition of individual-drug responses. Cell (2010) 1.75
Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock. Nature (2007) 1.74
Luciferase-YFP fusion tag with enhanced emission for single-cell luminescence imaging. Nat Methods (2007) 1.64
A model of the cell-autonomous mammalian circadian clock. Proc Natl Acad Sci U S A (2009) 1.46
Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling. BMC Bioinformatics (2007) 1.44
Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells. J Cell Sci (2002) 1.38
GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo. Genesis (2009) 1.33
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics. Mol Pharmacol (2004) 1.21
Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene (2005) 1.15
Cell culture medium affects GFP photostability: a solution. Nat Methods (2009) 1.14
Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophila. Cell Microbiol (2009) 1.07
A dynamic network of transcription in LPS-treated human subjects. BMC Syst Biol (2009) 1.07
High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines. BMC Cell Biol (2010) 1.06
Deciphering signaling outcomes from a system of complex networks. Sci Signal (2009) 1.05
Deterministic and stochastic models of NFkappaB pathway. Cardiovasc Toxicol (2007) 0.94
Bridging the gap between in silico and cell-based analysis of the nuclear factor-kappaB signaling pathway by in vitro studies of IKK2. FEBS J (2007) 0.94
Nuclear translocation kinetics of NF-kappaB in macrophages challenged with pathogens in a microfluidic platform. Biomed Microdevices (2009) 0.90
Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells. Mol Pharmacol (2008) 0.89
A whole-cell computational model predicts phenotype from genotype. Cell (2012) 5.98
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Genome-scale metabolic model of Helicobacter pylori 26695. J Bacteriol (2002) 4.00
Reconstruction of microbial transcriptional regulatory networks. Curr Opin Biotechnol (2004) 2.47
A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91
Reconciling gene expression data with known genome-scale regulatory network structures. Genome Res (2003) 1.65
Genome-scale metabolic networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.11
A forward-genetic screen and dynamic analysis of lambda phage host-dependencies reveals an extensive interaction network and a new anti-viral strategy. PLoS Genet (2010) 1.11
A dynamic network of transcription in LPS-treated human subjects. BMC Syst Biol (2009) 1.07
Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.04
Accelerated discovery via a whole-cell model. Nat Methods (2013) 1.01
WholeCellKB: model organism databases for comprehensive whole-cell models. Nucleic Acids Res (2012) 0.98
Towards a whole-cell modeling approach for synthetic biology. Chaos (2013) 0.95
The virus as metabolic engineer. Biotechnol J (2010) 0.94
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting. Mol Syst Biol (2012) 0.92
Single-cell and population NF-κB dynamic responses depend on lipopolysaccharide preparation. PLoS One (2013) 0.88
Determining host metabolic limitations on viral replication via integrated modeling and experimental perturbation. PLoS Comput Biol (2012) 0.82
WholeCellViz: data visualization for whole-cell models. BMC Bioinformatics (2013) 0.81
Simulating a living cell. Sci Am (2014) 0.75