Published in Mol Syst Biol on June 13, 2006
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol (2009) 6.58
Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature (2008) 4.63
p53 dynamics control cell fate. Science (2012) 3.30
Stochastic modelling for quantitative description of heterogeneous biological systems. Nat Rev Genet (2009) 3.27
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol (2009) 2.46
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Colored extrinsic fluctuations and stochastic gene expression. Mol Syst Biol (2008) 2.32
Strategies for cellular decision-making. Mol Syst Biol (2009) 2.29
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Heritable stochastic switching revealed by single-cell genealogy. PLoS Biol (2007) 2.11
Measuring and modeling apoptosis in single cells. Cell (2011) 2.10
Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol (2009) 2.05
Functional motifs in biochemical reaction networks. Annu Rev Phys Chem (2010) 2.04
Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A (2008) 2.03
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol (2011) 1.94
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. PLoS One (2009) 1.81
Impulse control: temporal dynamics in gene transcription. Cell (2011) 1.79
Synthetic biology: understanding biological design from synthetic circuits. Nat Rev Genet (2009) 1.70
Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol (2009) 1.69
Dynamics of single-cell gene expression. Mol Syst Biol (2006) 1.69
A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab (2011) 1.55
Cell fate decision mediated by p53 pulses. Proc Natl Acad Sci U S A (2009) 1.53
Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol (2009) 1.51
Sensitivity, robustness, and identifiability in stochastic chemical kinetics models. Proc Natl Acad Sci U S A (2011) 1.43
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Explaining oscillations and variability in the p53-Mdm2 system. BMC Syst Biol (2008) 1.31
Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep (2014) 1.21
Analysis and verification of the HMGB1 signaling pathway. BMC Bioinformatics (2010) 1.20
Calcium participates in feedback regulation of the oscillating ROP1 Rho GTPase in pollen tubes. Proc Natl Acad Sci U S A (2009) 1.19
High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol (2007) 1.19
Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19
Another turn for p53. Mol Syst Biol (2006) 1.19
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev (2011) 1.18
A systems biology view of cancer. Biochim Biophys Acta (2009) 1.17
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol (2013) 1.16
GPU accelerated biochemical network simulation. Bioinformatics (2011) 1.15
Dynamics of TGF-β/Smad signaling. FEBS Lett (2012) 1.12
Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death. Biophys J (2009) 1.11
Dynamics of a minimal model of interlocked positive and negative feedback loops of transcriptional regulation by cAMP-response element binding proteins. Biophys J (2007) 1.10
Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One (2011) 1.09
Transcription goes digital. EMBO Rep (2012) 1.06
Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation. J R Soc Interface (2013) 1.04
Modeling stochasticity and variability in gene regulatory networks. EURASIP J Bioinform Syst Biol (2012) 1.04
Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.04
Persistent cell-autonomous circadian oscillations in fibroblasts revealed by six-week single-cell imaging of PER2::LUC bioluminescence. PLoS One (2012) 1.04
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
Oscillations of the p53-Akt network: implications on cell survival and death. PLoS One (2009) 1.02
Stimulus-induced modulation of transcriptional bursting in a single mammalian gene. Proc Natl Acad Sci U S A (2013) 1.01
In silico models of cancer. Wiley Interdiscip Rev Syst Biol Med (2010) 1.01
Stress-specific response of the p53-Mdm2 feedback loop. BMC Syst Biol (2010) 0.99
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97
High-throughput, single-cell NF-κB dynamics. Curr Opin Genet Dev (2010) 0.96
Measurement and modeling of signaling at the single-cell level. Biochemistry (2012) 0.96
Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis (2010) 0.95
Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. J Biol Chem (2010) 0.95
Adjusting phenotypes by noise control. PLoS Comput Biol (2012) 0.94
The role of dimerisation and nuclear transport in the Hes1 gene regulatory network. Bull Math Biol (2013) 0.94
A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach. PLoS One (2009) 0.93
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Identification of novel targets for breast cancer by exploring gene switches on a genome scale. BMC Genomics (2011) 0.92
Complex dynamics of transcription regulation. Biochim Biophys Acta (2012) 0.92
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Evaluating gene expression dynamics using pairwise RNA FISH data. PLoS Comput Biol (2010) 0.91
Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91
Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system. Biophys J (2010) 0.90
Analysis of intercellular signal transduction in the tumor microenvironment. BMC Syst Biol (2013) 0.89
Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics. PLoS One (2009) 0.89
Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia. Genome Med (2015) 0.89
Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep (2013) 0.88
Modeling the role of p53 pulses in DNA damage- induced cell death decision. BMC Bioinformatics (2009) 0.88
High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations. PLoS One (2014) 0.87
Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate. BMC Syst Biol (2013) 0.87
Collective dynamics of gene expression in cell populations. PLoS One (2011) 0.87
GSK3 and p53 - is there a link in Alzheimer's disease? Mol Neurodegener (2010) 0.86
Least-squares methods for identifying biochemical regulatory networks from noisy measurements. BMC Bioinformatics (2007) 0.86
Sustained oscillations in extended genetic oscillatory systems. Biophys J (2008) 0.85
Decision making of the p53 network: death by integration. J Theor Biol (2010) 0.85
Live cell imaging and systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
Simple molecular networks that respond optimally to time-periodic stimulation. BMC Syst Biol (2009) 0.84
Determinants of cell-to-cell variability in protein kinase signaling. PLoS Comput Biol (2013) 0.84
A dynamical model reveals gene co-localizations in nucleus. PLoS Comput Biol (2011) 0.84
Single-cell variation leads to population invariance in NF-κB signaling dynamics. Mol Biol Cell (2014) 0.84
Determining biological noise via single cell analysis. Anal Bioanal Chem (2008) 0.84
A theoretical exploration of birhythmicity in the p53-Mdm2 network. PLoS One (2011) 0.84
On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study. Cell Cycle (2013) 0.83
Hybrid Modeling of Cell Signaling and Transcriptional Reprogramming and Its Application in C. elegans Development. Front Genet (2011) 0.83
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model. Bioessays (2015) 0.83
Modeling the basal dynamics of p53 system. PLoS One (2011) 0.83
Comparisons of robustness and sensitivity between cancer and normal cells by microarray data. Cancer Inform (2008) 0.83
Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage. PLoS Comput Biol (2010) 0.83
Moment fitting for parameter inference in repeatedly and partially observed stochastic biological models. PLoS One (2012) 0.82
Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks. J R Soc Interface (2013) 0.82
The role of mRNA decay in p53-induced gene expression. RNA (2011) 0.82
Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling. BMC Syst Biol (2010) 0.82
NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82
Biological clues to potent DNA-damaging activities in food and flavoring. Food Chem Toxicol (2013) 0.82
Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52
Network motifs: simple building blocks of complex networks. Science (2002) 35.80
Surfing the p53 network. Nature (2000) 35.36
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Stochastic gene expression in a single cell. Science (2002) 34.54
Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28
From molecular to modular cell biology. Nature (1999) 23.51
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
Network motifs in the transcriptional regulation network of Escherichia coli. Nat Genet (2002) 19.57
Regulation of p53 stability by Mdm2. Nature (1997) 18.20
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
Live or let die: the cell's response to p53. Nat Rev Cancer (2002) 15.06
Regulation of noise in the expression of a single gene. Nat Genet (2002) 14.93
Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON. Proc Natl Acad Sci U S A (1957) 14.34
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Stochastic mechanisms in gene expression. Proc Natl Acad Sci U S A (1997) 13.65
Noise in eukaryotic gene expression. Nature (2003) 13.01
Engineering stability in gene networks by autoregulation. Nature (2000) 12.88
Control of stochasticity in eukaryotic gene expression. Science (2004) 12.85
Robustness in bacterial chemotaxis. Nature (1999) 12.55
Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci U S A (2003) 12.50
Robustness in simple biochemical networks. Nature (1997) 12.21
Intrinsic noise in gene regulatory networks. Proc Natl Acad Sci U S A (2001) 12.06
Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05
Gene regulation at the single-cell level. Science (2005) 11.52
The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19
Real-time kinetics of gene activity in individual bacteria. Cell (2005) 11.08
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Biological robustness. Nat Rev Genet (2004) 9.98
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Noise in gene expression: origins, consequences, and control. Science (2005) 9.64
Summing up the noise in gene networks. Nature (2004) 9.62
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol (2003) 8.91
Signaling to p53: breaking the MDM2-p53 circuit. Cell (1998) 8.63
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet (1999) 7.09
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem (1998) 6.84
The p53 pathway. J Pathol (1999) 6.79
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell (2004) 6.44
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol (2003) 5.86
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell (2005) 5.71
Regulated cell-to-cell variation in a cell-fate decision system. Nature (2005) 5.68
Non-genetic individuality: chance in the single cell. Nature (1976) 5.52
Decision making by p53: life, death and cancer. Cell Death Differ (2003) 5.52
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci U S A (2003) 5.07
The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol (2003) 4.46
Circadian clocks limited by noise. Nature (2000) 4.39
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature (2002) 4.21
Biological networks: the tinkerer as an engineer. Science (2003) 4.15
Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat Genet (2005) 4.07
Resilient circadian oscillator revealed in individual cyanobacteria. Nature (2004) 3.84
Mechanisms of noise-resistance in genetic oscillators. Proc Natl Acad Sci U S A (2002) 3.78
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction. Proc Natl Acad Sci U S A (2004) 3.60
Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays. Curr Biol (2003) 3.54
Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science (2005) 3.48
Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol (2001) 3.46
Computational approaches to cellular rhythms. Nature (2002) 3.40
Regulation of p53 in response to DNA damage. Oncogene (1999) 3.23
Origins of extrinsic variability in eukaryotic gene expression. Nature (2005) 3.18
The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli. J Mol Biol (2005) 3.13
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets (2005) 3.04
MDM2--master regulator of the p53 tumor suppressor protein. Gene (2000) 2.92
Steady states and oscillations in the p53/Mdm2 network. Cell Cycle (2005) 2.45
Using a quantitative blueprint to reprogram the dynamics of the flagella gene network. Cell (2004) 2.41
A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Synthetic gene network for entraining and amplifying cellular oscillations. Phys Rev Lett (2002) 2.24
The p53 response to DNA damage. DNA Repair (Amst) (2004) 2.14
Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. PLoS Biol (2005) 1.84
Mdm2: keeping p53 under control. Oncogene (1997) 1.83
Keeping an old friend under control: regulation of p53 stability. Mol Med Today (1998) 1.29
Low-dose radiation: thresholds, bystander effects, and adaptive responses. Proc Natl Acad Sci U S A (2003) 1.24
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. Syst Biol (Stevenage) (2005) 1.15
The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE (2004) 1.12
Regulation of p53 protein expression in human breast cancer cell lines. J Cell Sci (1993) 1.10
Monitoring p53's pulse. Nat Genet (2004) 0.91
Low-dose-rate radiation attenuates the response of the tumor suppressor TP53. Radiat Res (1999) 0.86
Tracing the sources of cellular variation. Dev Cell (2005) 0.81
And the noise played on: stochastic gene expression and HIV-1 infection. Cell (2005) 0.81
Network motifs in the transcriptional regulation network of Escherichia coli. Nat Genet (2002) 19.57
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med (2013) 13.22
Gene regulation at the single-cell level. Science (2005) 11.52
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell (2007) 9.51
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
Superfamilies of evolved and designed networks. Science (2004) 8.12
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 7.42
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Negative autoregulation speeds the response times of transcription networks. J Mol Biol (2002) 6.32
Variability and memory of protein levels in human cells. Nature (2006) 6.15
Optimality and evolutionary tuning of the expression level of a protein. Nature (2005) 5.94
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med (2012) 5.69
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
Spontaneous evolution of modularity and network motifs. Proc Natl Acad Sci U S A (2005) 4.49
A module of negative feedback regulators defines growth factor signaling. Nat Genet (2007) 4.35
Just-in-time transcription program in metabolic pathways. Nat Genet (2004) 4.30
Assigning numbers to the arrows: parameterizing a gene regulation network by using accurate expression kinetics. Proc Natl Acad Sci U S A (2002) 4.20
A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods (2006) 3.95
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction. Proc Natl Acad Sci U S A (2004) 3.60
Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol (2009) 3.47
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
Proteome half-life dynamics in living human cells. Science (2011) 3.34
p53 dynamics control cell fate. Science (2012) 3.30
Plasticity of the cis-regulatory input function of a gene. PLoS Biol (2006) 3.22
Adaptive prediction of environmental changes by microorganisms. Nature (2009) 3.19
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature (2011) 3.08
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Collective and single cell behavior in epithelial contact inhibition. Proc Natl Acad Sci U S A (2012) 2.80
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci U S A (2007) 2.64
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63
Disruption of cancer cell replication by alternating electric fields. Cancer Res (2004) 2.62
Diverse two-dimensional input functions control bacterial sugar genes. Mol Cell (2008) 2.60
The genetic code is nearly optimal for allowing additional information within protein-coding sequences. Genome Res (2007) 2.56
Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters. Biochemistry (2011) 2.42
Using a quantitative blueprint to reprogram the dynamics of the flagella gene network. Cell (2004) 2.41
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Differential relationship of DNA replication timing to different forms of human mutation and variation. Am J Hum Genet (2012) 2.33
Input output robustness in simple bacterial signaling systems. Proc Natl Acad Sci U S A (2007) 2.17
Cost of unneeded proteins in E. coli is reduced after several generations in exponential growth. Mol Cell (2010) 2.17
Response delays and the structure of transcription networks. J Mol Biol (2003) 2.15
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
The incoherent feed-forward loop can generate non-monotonic input functions for genes. Mol Syst Biol (2008) 2.13
Central carbon metabolism as a minimal biochemical walk between precursors for biomass and energy. Mol Cell (2010) 2.08
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli. Mol Syst Biol (2005) 1.97
Genetic and phenotypic diversity in breast tumor metastases. Cancer Res (2014) 1.96
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy. Nat Protoc (2011) 1.94
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91
MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol (2008) 1.90
Environmental variability and modularity of bacterial metabolic networks. BMC Evol Biol (2007) 1.88
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci U S A (2008) 1.87
High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86
Design and analysis of synthetic carbon fixation pathways. Proc Natl Acad Sci U S A (2010) 1.85
Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. PLoS Biol (2005) 1.84
Varying environments can speed up evolution. Proc Natl Acad Sci U S A (2007) 1.81
The mirror game as a paradigm for studying the dynamics of two people improvising motion together. Proc Natl Acad Sci U S A (2011) 1.76
Glycolytic strategy as a tradeoff between energy yield and protein cost. Proc Natl Acad Sci U S A (2013) 1.75
Protein dynamics in drug combinations: a linear superposition of individual-drug responses. Cell (2010) 1.75
eQuilibrator--the biochemical thermodynamics calculator. Nucleic Acids Res (2011) 1.73
A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Nat Neurosci (2007) 1.72
Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell (2011) 1.70
Coarse-graining and self-dissimilarity of complex networks. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 1.67
Fold-change detection and scalar symmetry of sensory input fields. Proc Natl Acad Sci U S A (2010) 1.67
Search for computational modules in the C. elegans brain. BMC Biol (2004) 1.61
Environmental selection of the feed-forward loop circuit in gene-regulation networks. Phys Biol (2005) 1.59