Published in Sci Signal on October 20, 2009
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature (2014) 3.86
p53 dynamics control cell fate. Science (2012) 3.30
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Tunable signal processing through modular control of transcription factor translocation. Science (2013) 2.11
Measuring and modeling apoptosis in single cells. Cell (2011) 2.10
Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol (2011) 1.94
Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci U S A (2010) 1.66
Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells. J Cell Sci (2010) 1.38
Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol (2012) 1.30
Lessons from mathematically modeling the NF-κB pathway. Immunol Rev (2012) 1.22
High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines. BMC Cell Biol (2010) 1.06
Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling. Sci Signal (2014) 1.05
The future of whole-cell modeling. Curr Opin Biotechnol (2014) 1.01
Akt fine-tunes NF-κB-dependent gene expression during T cell activation. J Biol Chem (2011) 0.97
High-throughput, single-cell NF-κB dynamics. Curr Opin Genet Dev (2010) 0.96
Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening. PLoS One (2012) 0.90
Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev (2014) 0.90
A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs. PPAR Res (2011) 0.90
Spontaneous NF-κB activation by autocrine TNFα signaling: a computational analysis. PLoS One (2013) 0.89
Deep Learning Automates the Quantitative Analysis of Individual Cells in Live-Cell Imaging Experiments. PLoS Comput Biol (2016) 0.89
Single-cell and population NF-κB dynamic responses depend on lipopolysaccharide preparation. PLoS One (2013) 0.88
Live cell imaging and systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep (2016) 0.84
Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters. Proc Natl Acad Sci U S A (2014) 0.84
Single-cell variation leads to population invariance in NF-κB signaling dynamics. Mol Biol Cell (2014) 0.84
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model. Bioessays (2015) 0.83
Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. Cell Syst (2016) 0.83
NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82
Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection. Elife (2015) 0.82
Digital signaling decouples activation probability and population heterogeneity. Elife (2015) 0.82
Observing single cell NF-κB dynamics under stimulant concentration gradient. Anal Chem (2012) 0.82
Quantitative characterization and analysis of the dynamic NF-κB response in microglia. BMC Bioinformatics (2011) 0.81
Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator. Angew Chem Int Ed Engl (2015) 0.81
Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends Biotechnol (2016) 0.80
Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol (2012) 0.79
Distinct cellular states determine calcium signaling response. Mol Syst Biol (2016) 0.79
Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78
A checklist for successful quantitative live cell imaging in systems biology. Cells (2013) 0.78
Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. Elife (2016) 0.78
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection. PLoS One (2013) 0.77
Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform. PLoS One (2013) 0.76
Toll-like Receptor function of murine macrophages, probed by cytokine induction, is biphasic and is not impaired globally with age. Mech Ageing Dev (2016) 0.76
Statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling networks. BMC Syst Biol (2013) 0.76
Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo. J Biol Chem (2012) 0.75
Importins promote high-frequency NF-κB oscillations increasing information channel capacity. Biol Direct (2016) 0.75
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol. Sci Rep (2017) 0.75
Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88. Sci Rep (2017) 0.75
Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages. Sci Signal (2016) 0.75
Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action. Immunity (2017) 0.75
Stochastic gene expression in a single cell. Science (2002) 34.54
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Bacterial persistence as a phenotypic switch. Science (2004) 15.80
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene (1999) 13.46
Noise in gene expression: origins, consequences, and control. Science (2005) 9.64
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Universally sloppy parameter sensitivities in systems biology models. PLoS Comput Biol (2007) 7.89
Noise in gene expression determines cell fate in Bacillus subtilis. Science (2007) 7.45
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol (2004) 7.23
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
An excitable gene regulatory circuit induces transient cellular differentiation. Nature (2006) 6.03
Stochastic switching as a survival strategy in fluctuating environments. Nat Genet (2008) 5.87
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest (2001) 5.87
Toll-like receptor signaling pathways. Science (2003) 5.86
Tunability and noise dependence in differentiation dynamics. Science (2007) 5.23
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science (2005) 4.83
Computational cluster validation in post-genomic data analysis. Bioinformatics (2005) 4.46
Stochasticity and cell fate. Science (2008) 4.39
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev (1993) 4.23
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14
Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev (2007) 3.16
Stochastic spineless expression creates the retinal mosaic for colour vision. Nature (2006) 3.09
Mathematical model of NF-kappaB regulatory module. J Theor Biol (2004) 2.75
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci U S A (2006) 1.96
A TNF-induced gene expression program under oscillatory NF-kappaB control. BMC Genomics (2005) 1.92
Physiological functions for brain NF-kappaB. Trends Neurosci (2005) 1.85
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling. BMC Bioinformatics (2007) 1.44
From fluctuations to phenotypes: the physiology of noise. Sci STKE (2006) 1.41
Stochastic model of autocrine and paracrine signals in cell culture assays. Biophys J (2003) 1.39
Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells. J Cell Sci (2002) 1.38
Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha. Syst Biol (Stevenage) (2004) 1.36
GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo. Genesis (2009) 1.33
Automated tracking of gene expression in individual cells and cell compartments. J R Soc Interface (2006) 1.30
NF-kappaB oscillations and cell-to-cell variability. J Theor Biol (2005) 1.25
Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling. Endocrinology (2005) 1.20
Synergistic control of oscillations in the NF-kappaB signalling pathway. Syst Biol (Stevenage) (2005) 1.14
Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome Res (2003) 1.12
Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol (2006) 0.99
Deterministic and stochastic models of NFkappaB pathway. Cardiovasc Toxicol (2007) 0.94
Sensitivity analysis of a computational model of the IKK NF-kappaB IkappaBalpha A20 signal transduction network. Ann N Y Acad Sci (2007) 0.89
A whole-cell computational model predicts phenotype from genotype. Cell (2012) 5.98
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science (2005) 4.83
Genome-scale metabolic model of Helicobacter pylori 26695. J Bacteriol (2002) 4.00
CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J (2002) 2.90
Reconstruction of microbial transcriptional regulatory networks. Curr Opin Biotechnol (2004) 2.47
Reconciling gene expression data with known genome-scale regulatory network structures. Genome Res (2003) 1.65
Genome-scale metabolic networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.11
A forward-genetic screen and dynamic analysis of lambda phage host-dependencies reveals an extensive interaction network and a new anti-viral strategy. PLoS Genet (2010) 1.11
A dynamic network of transcription in LPS-treated human subjects. BMC Syst Biol (2009) 1.07
Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.04
Accelerated discovery via a whole-cell model. Nat Methods (2013) 1.01
WholeCellKB: model organism databases for comprehensive whole-cell models. Nucleic Acids Res (2012) 0.98
High-throughput, single-cell NF-κB dynamics. Curr Opin Genet Dev (2010) 0.96
Towards a whole-cell modeling approach for synthetic biology. Chaos (2013) 0.95
The virus as metabolic engineer. Biotechnol J (2010) 0.94
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting. Mol Syst Biol (2012) 0.92
Single-cell and population NF-κB dynamic responses depend on lipopolysaccharide preparation. PLoS One (2013) 0.88
Determining host metabolic limitations on viral replication via integrated modeling and experimental perturbation. PLoS Comput Biol (2012) 0.82
WholeCellViz: data visualization for whole-cell models. BMC Bioinformatics (2013) 0.81
Simulating a living cell. Sci Am (2014) 0.75