Published in J Cell Biol on July 30, 2007
3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open (2012) 2.23
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell (2008) 2.12
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J Cell Biol (2009) 1.64
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J (2010) 1.48
Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One (2011) 1.45
Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission. J Cell Biol (2010) 1.43
Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J Cell Biol (2010) 1.42
Breaking the ties that bind: new advances in centrosome biology. J Cell Biol (2012) 1.41
The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol (2011) 1.36
Structural and regulatory roles of nonmotor spindle proteins. Curr Opin Cell Biol (2008) 1.34
CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment. Nat Cell Biol (2012) 1.27
Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy. Cell Death Differ (2012) 1.17
Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. J Cell Biol (2009) 1.15
Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules. J Biol Chem (2012) 1.05
Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. J Cell Biol (2012) 1.04
Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells. Curr Biol (2009) 1.00
A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage. Mol Biol Cell (2010) 0.99
Astrin regulates Aurora-A localization. Biochem Biophys Res Commun (2008) 0.97
Separate to operate: control of centrosome positioning and separation. Philos Trans R Soc Lond B Biol Sci (2014) 0.96
Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. J Cell Sci (2012) 0.96
The multifunctional SNM1 gene family: not just nucleases. Future Oncol (2010) 0.91
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife (2015) 0.90
Possible functional links among brain- and skull-related genes selected in modern humans. Front Psychol (2015) 0.89
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. Elife (2015) 0.88
Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res (2012) 0.86
Centrosome dynamics as a source of chromosomal instability. Trends Cell Biol (2014) 0.84
A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends. J Cell Biol (2016) 0.84
Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget (2013) 0.83
Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B. Mol Biol Cell (2011) 0.82
Mechanisms of Chromosome Congression during Mitosis. Biology (Basel) (2017) 0.82
Sensors at centrosomes reveal determinants of local separase activity. PLoS Genet (2014) 0.81
Kinetochore-microtubule stability governs the metaphase requirement for Eg5. Mol Biol Cell (2014) 0.81
Centrioles: some self-assembly required. Curr Opin Cell Biol (2008) 0.81
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division. Cell Rep (2015) 0.80
miR-539 inhibits prostate cancer progression by directly targeting SPAG5. J Exp Clin Cancer Res (2016) 0.79
The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically. Cilia (2012) 0.79
Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion. J Cell Biol (2014) 0.78
SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway. Cell Death Dis (2014) 0.78
Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun (2016) 0.78
Centrosomes in the DNA damage response-the hub outside the centre. Chromosome Res (2016) 0.77
CENP-W plays a role in maintaining bipolar spindle structure. PLoS One (2014) 0.77
Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Oncogene (2015) 0.76
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy (2017) 0.75
Kizuna is a novel mitotic substrate for CDC25B phosphatase. Cell Cycle (2014) 0.75
Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle. J Biol Chem (2016) 0.75
Is cohesin required for spindle-pole-body/centrosome cohesion? Commun Integr Biol (2012) 0.75
Regulation of the centrosome cycle. Mol Cell Oncol (2015) 0.75
Phosphorylation of Astrin Regulates Its Kinetochore Function. J Biol Chem (2016) 0.75
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun (2017) 0.75
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80. Elife (2017) 0.75
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell (2000) 5.69
CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature (1992) 5.54
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell (1998) 5.29
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell (2000) 5.10
Mechanism limiting centrosome duplication to once per cell cycle. Nature (2006) 4.69
The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol (2002) 4.53
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
The structure of the cold-stable kinetochore fiber in metaphase PtK1 cells. Chromosoma (1981) 4.11
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80
hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J Cell Biol (2002) 3.69
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33
Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles. J Cell Sci (1996) 3.27
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol (1998) 3.11
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev (2003) 2.75
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol Biol Cell (2004) 2.65
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J (2006) 2.14
Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Mol Biol Cell (2005) 2.09
Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Proc Natl Acad Sci U S A (2001) 2.02
Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86
Centriole distribution during tripolar mitosis in Chinese hamster ovary cells. J Cell Biol (1984) 1.83
Centriole number and the reproductive capacity of spindle poles. J Cell Biol (1985) 1.80
Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Mol Biol Cell (2004) 1.73
Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol Cell (2005) 1.72
Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis. EMBO J (2004) 1.55
Centrosomes split in the presence of impaired DNA integrity during mitosis. Mol Biol Cell (2003) 1.49
Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. J Cell Sci (2005) 1.46
Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction. J Cell Sci (2006) 1.24
The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J Cell Sci (2002) 1.18
Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins. Biochem Biophys Res Commun (2001) 0.98
Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol (2004) 7.22
The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol (2005) 5.84
Plk4-induced centriole biogenesis in human cells. Dev Cell (2007) 5.68
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science (2002) 4.94
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54
Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol (2003) 4.31
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98
Cytokinesis: placing and making the final cut. Cell (2007) 3.90
Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol (2007) 3.88
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene (2005) 3.64
Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Cell cycle regulation of central spindle assembly. Nature (2004) 3.27
HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol (2006) 3.21
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol (2003) 3.12
Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev (2004) 2.96
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev (2007) 2.92
Control of centriole length by CPAP and CP110. Curr Biol (2009) 2.67
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat Cell Biol (2007) 2.54
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J (2002) 2.41
Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol (2005) 2.41
Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO Rep (2002) 2.40
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell (2005) 2.40
Rootletin forms centriole-associated filaments and functions in centrosome cohesion. J Cell Biol (2005) 2.38
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38
The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31
Proteome analysis of the human mitotic spindle. Mol Cell Proteomics (2004) 2.31
Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells (2002) 2.28
Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation. Nature (2005) 2.26
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science (2013) 2.25
3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open (2012) 2.23
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell (2003) 2.18
The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell (2004) 2.17
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J (2006) 2.14
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14
Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Mol Biol Cell (2005) 2.09
KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol (2006) 2.06
Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell (2006) 1.94
The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91
Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma (2007) 1.78
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci (2007) 1.78
Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J (2009) 1.76
Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. J Cell Sci (2010) 1.74
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol (2010) 1.73
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. J Cell Sci (2002) 1.73
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J Cell Biol (2009) 1.64
Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. J Biol Chem (2002) 1.63
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. J Cell Sci (2006) 1.62
Cell-cycle-regulated expression of STIL controls centriole number in human cells. J Cell Sci (2012) 1.60
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biol (2010) 1.60
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma (2008) 1.60
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton (2004) 1.59
Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev (2005) 1.57
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. J Cell Sci (2013) 1.55
Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53
Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem (2002) 1.47
A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol Biol Cell (2005) 1.45
Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1. J Cell Sci (2010) 1.42
Centrosome-associated NDR kinase regulates centrosome duplication. Mol Cell (2007) 1.37
The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol (2011) 1.36
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. J Cell Biol (2005) 1.34
Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs. Chromosoma (2009) 1.33
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene (2003) 1.33
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma (2004) 1.30
Sgt1 is required for human kinetochore assembly. EMBO Rep (2004) 1.30
Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division. J Cell Sci (2010) 1.28
Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Genes Dev (2003) 1.27
Cytostatic factor: an activity that puts the cell cycle on hold. J Cell Sci (2006) 1.27
Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations. Mol Cancer Ther (2012) 1.26
Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases. Mol Cell Biol (2005) 1.26
Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. J Cell Sci (2005) 1.25
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev (2012) 1.23
The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell (2013) 1.23
Protein phosphatases and the regulation of mitosis. J Cell Sci (2011) 1.23
Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamics. Mol Biol Cell (2005) 1.20
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J (2011) 1.19
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol (2002) 1.19
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol Biol Cell (2008) 1.19
Inhibition of centrosome separation after DNA damage: a role for Nek2. Radiat Res (2004) 1.18
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol (2013) 1.13
The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Curr Biol (2008) 1.13
Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface. Mol Cell (2012) 1.11
Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects. EMBO Rep (2005) 1.10
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. J Cell Biol (2012) 1.09
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Anal Chem (2008) 1.06