NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMID 20956937)

Published in Oncogene on October 18, 2010

Authors

B Wang1, M K Hasan, E Alvarado, H Yuan, H Wu, W Y Chen

Author Affiliations

1: Department of Cancer Biology, City of Hope, Duarte, CA, USA.

Articles citing this

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest (2013) 1.72

The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood (2011) 1.52

Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47

The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet (2011) 1.41

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. J Biol Chem (2012) 1.36

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood (2012) 1.23

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells. Oncogene (2012) 1.15

Rejuvenating sirtuins: the rise of a new family of cancer drug targets. Curr Pharm Des (2013) 1.01

Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. PLoS One (2012) 1.00

Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res (2013) 1.00

Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00

Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97

Nicotinamide phosphoribosyltransferase in malignancy: a review. Genes Cancer (2013) 0.97

Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. PLoS One (2013) 0.95

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. PLoS One (2014) 0.93

Lung cancer signature biomarkers: tissue specific semantic similarity based clustering of digital differential display (DDD) data. BMC Res Notes (2012) 0.92

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS One (2011) 0.90

Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol (2013) 0.88

Transcriptome-wide detection of differentially expressed coding and non-coding transcripts and their clinical significance in prostate cancer. J Oncol (2012) 0.87

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. Int J Cancer (2012) 0.86

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep (2013) 0.85

Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell (2014) 0.84

Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration. PLoS One (2013) 0.84

Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. Am J Pathol (2015) 0.84

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metab (2016) 0.83

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity. Open Biol (2013) 0.82

NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents. Proc Natl Acad Sci U S A (2014) 0.81

Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. Hematol Rep (2012) 0.81

Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer. DNA Repair (Amst) (2014) 0.80

Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways. Clin Pharmacol (2015) 0.80

Secretion of one adipokine Nampt/Visfatin suppresses the inflammatory stress-induced NF-κB activity and affects Nampt-dependent cell viability in Huh-7 cells. Mediators Inflamm (2015) 0.80

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine. Br J Pharmacol (2016) 0.79

Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer. Croat Med J (2014) 0.79

The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal (2014) 0.79

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer (2015) 0.78

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells. J Biol Chem (2015) 0.78

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer. Oncogene (2015) 0.78

Identification of novel pathogenic copy number aberrations in multiple myeloma: the Malaysian context. Mol Cytogenet (2014) 0.77

Effect of SIRT1 Gene on Epithelial-Mesenchymal Transition of Human Prostate Cancer PC-3 Cells. Med Sci Monit (2016) 0.77

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. Oncotarget (2016) 0.76

Nampt is involved in DNA double-strand break repair. Chin J Cancer (2012) 0.76

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population. Int J Mol Sci (2015) 0.76

New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology. Mol Cell Oncol (2015) 0.76

Adipocyte Derived Hormones Gene Expression, Resistin and Visfatin, in AGS Gastric Cancer Cell Line. Iran J Cancer Prev (2013) 0.75

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT. Oncotarget (2016) 0.75

Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulation. Oncotarget (2016) 0.75

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proc Natl Acad Sci U S A (2016) 0.75

Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer. J Cancer (2015) 0.75

Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression. Oncotarget (2017) 0.75

Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway. Biomed Res Int (2016) 0.75

FOXO3a: A Potential Target in Prostate Cancer. Austin J Urol (2015) 0.75

High visfatin expression predicts poor prognosis of upper tract urothelial carcinoma patients. Am J Cancer Res (2015) 0.75

A 25-gene classifier predicts overall survival in resectable pancreatic cancer. BMC Med (2017) 0.75

Articles by these authors

miR-21-mediated tumor growth. Oncogene (2006) 9.90

Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis (2000) 9.45

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A (2001) 6.99

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol (1995) 6.33

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19

A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev (1998) 5.14

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell (1998) 4.77

The three-dimensional structure of canine parvovirus and its functional implications. Science (1991) 3.87

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest (1995) 3.52

Brassinosteroid-insensitive dwarf mutants of Arabidopsis accumulate brassinosteroids. Plant Physiol (1999) 3.37

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem (2000) 3.26

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18

Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal Chem (2000) 2.81

Pharmacokinetics of sevoflurane uptake into the brain and body. Anaesthesia (2003) 2.78

Structural basis for self-association and receptor recognition of human TRAF2. Nature (1999) 2.74

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem (1999) 2.67

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67

Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57

N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology (2001) 2.51

Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell (2001) 2.43

Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A (1997) 2.37

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol (1995) 2.30

Binding of peptides with basic residues to membranes containing acidic phospholipids. Biophys J (1991) 2.30

The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. Plant Physiol (1999) 2.26

The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell (1999) 2.25

In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia. J Am Coll Cardiol (1998) 2.23

Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother (1998) 2.19

Morphometric and electron-microscopic analyses of the effects of gonadotropin-releasing hormone agonists on uterine leiomyomas. Arch Pathol Lab Med (1998) 2.11

Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn (1997) 2.05

Acute renal failure requiring dialysis after percutaneous coronary interventions. Catheter Cardiovasc Interv (2001) 1.93

Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. Clin Cancer Res (2001) 1.93

Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa. Int J Tuberc Lung Dis (2010) 1.92

The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation. J Am Coll Cardiol (1998) 1.91

Management and outcome of pyogenic vertebral osteomyelitis. Clin Orthop Relat Res (1978) 1.88

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol (2001) 1.86

Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest (1997) 1.86

Longitudinal study of brain morphology in first episode schizophrenia. Biol Psychiatry (2001) 1.86

Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science (2001) 1.84

A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis. Proc Natl Acad Sci U S A (1998) 1.79

TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. J Cell Sci (2001) 1.76

Renal abnormalities in schoolchildren. Pediatrics (1989) 1.74

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am J Psychiatry (1994) 1.72

Efficient gene transfer to airway epithelium using recombinant Sendai virus. Nat Biotechnol (2000) 1.71

High-cooperativity coupling of electron-spin ensembles to superconducting cavities. Phys Rev Lett (2010) 1.69

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem (2001) 1.66

A distinct spectrum of SLC26A4 mutations in patients with enlarged vestibular aqueduct in China. Clin Genet (2007) 1.66

Detection of mecA, femA, and femB genes in clinical strains of staphylococci using polymerase chain reaction. Epidemiol Infect (1994) 1.64

Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A (2000) 1.64

Heat and water loss from the airways and exercise-induced asthma. Respiration (1977) 1.63

Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry (1999) 1.61

Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol (1994) 1.61

Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer (2004) 1.61

Bipartite signal for read-through suppression in murine leukemia virus mRNA: an eight-nucleotide purine-rich sequence immediately downstream of the gag termination codon followed by an RNA pseudoknot. J Virol (1992) 1.60

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene (2006) 1.59

Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J Comp Neurol (1999) 1.57

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A (1997) 1.57

Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem (1996) 1.56

Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions. Proc Natl Acad Sci U S A (1995) 1.56

Hepatitis C seroprevalence among newly incarcerated inmates in the Texas correctional system. Public Health (2003) 1.55

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55

Valproic acid therapy in childhood epilepsy. JAMA (1980) 1.54

Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. J Virol (1999) 1.54

Malignant rhabdoid tumour of colon. Histopathology (1994) 1.54

Mesohepatectomy for centrally located liver tumours. Br J Surg (2013) 1.53

Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol (1996) 1.53

In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am J Pathol (2000) 1.51

Phase-sensitive optical time-domain reflectometry with Brillouin amplification. Opt Lett (2014) 1.51

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature (2001) 1.51

Laparoscopic fusion of the lumbar spine: minimally invasive spine surgery. A prospective multicenter study evaluating open and laparoscopic lumbar fusion. Spine (Phila Pa 1976) (1999) 1.51

Four-year follow-up results of lumbar spine arthrodesis using the Bagby and Kuslich lumbar fusion cage. Spine (Phila Pa 1976) (2000) 1.50

In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression. J Virol (1997) 1.48

Transforming growth factor-beta - and tumor necrosis factor-alpha -mediated induction and proteolytic activation of MMP-9 in human skin. J Biol Chem (2001) 1.48

The role of lipoprotein processing by signal peptidase II in the Gram-positive eubacterium bacillus subtilis. Signal peptidase II is required for the efficient secretion of alpha-amylase, a non-lipoprotein. J Biol Chem (1999) 1.45

Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev (1997) 1.45

D-Alanine substitution of teichoic acids as a modulator of protein folding and stability at the cytoplasmic membrane/cell wall interface of Bacillus subtilis. J Biol Chem (2000) 1.44

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure (1995) 1.42

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature (1995) 1.41

The association of glutathione S-transferase polymorphisms in patients with osteosarcoma: evidence from a meta-analysis. Eur J Cancer Care (Engl) (2014) 1.41

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol (2000) 1.40

Interleukin 1alpha (IL-1alpha) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function. Mol Psychiatry (2004) 1.40

Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem (2001) 1.39

Heart rate turbulence in masked hypertension and white-coat hypertension. Eur Rev Med Pharmacol Sci (2015) 1.38

Can intracatheter retention of antifungal agents cure fungal peritonitis? Two cases successfully treated without catheter removal. Perit Dial Int (1991) 1.38

Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol Cell Biol (1994) 1.37

Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol (2001) 1.34

Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics. Math Biosci (1999) 1.34

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem (1998) 1.34

Real time TaqMan PCR detection and quantitation of HBV genotypes A-G with the use of an internal quantitation standard. J Clin Virol (2004) 1.34

Hippocampal/amygdala volumes in geriatric depression. Psychol Med (1999) 1.33

Absence of BRAF mutations in UV-protected mucosal melanomas. J Med Genet (2004) 1.32

NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene (2011) 1.32

Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology (1997) 1.30

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. J Med Chem (1998) 1.30

Characterization of a self-splicing mini-intein and its conversion into autocatalytic N- and C-terminal cleavage elements: facile production of protein building blocks for protein ligation. Gene (1999) 1.29

Morphological variety of the soft palate in normal individuals: a digital cephalometric study. Dentomaxillofac Radiol (2008) 1.28