Published in EMBO J on August 02, 1999
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J (2003) 2.89
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
The links between axin and carcinogenesis. J Clin Pathol (2005) 2.07
Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A (2003) 2.06
Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J Biol (2005) 2.06
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A (2003) 2.01
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Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A (2002) 1.96
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol (2000) 1.93
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Phospho-regulation of Beta-catenin adhesion and signaling functions. Physiology (Bethesda) (2007) 1.89
Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol (2008) 1.89
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol (2001) 1.59
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J (2003) 1.57
Role of Wnt/β-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol (2009) 1.55
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia (2004) 1.54
Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 1.46
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
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The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev (2002) 1.39
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol (2001) 1.36
Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. J Cell Biol (2001) 1.36
Mouse axin and axin2/conductin proteins are functionally equivalent in vivo. Mol Cell Biol (2005) 1.35
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem (2008) 1.35
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol (2008) 1.27
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol Cell Biol (2000) 1.23
Deconstructing GSK-3: The Fine Regulation of Its Activity. Int J Alzheimers Dis (2011) 1.22
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. Mol Cell Biol (2002) 1.20
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J (2010) 1.19
Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster. Mol Cell Biol (2004) 1.15
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc Natl Acad Sci U S A (2001) 1.13
Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol Cell Biol (2004) 1.06
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J (2008) 1.05
Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal (2009) 1.01
Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. J Biol Chem (2009) 1.01
Lrp6 is required for convergent extension during Xenopus gastrulation. Development (2007) 1.00
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β. Cell Mol Life Sci (2010) 0.99
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J Biol Chem (2009) 0.99
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem (2008) 0.98
Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication. Neural Plast (2013) 0.96
Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway. J Biol Chem (2010) 0.96
Signalling activity of beta-catenin targeted to different subcellular compartments. Biochem J (2004) 0.96
Wnt signaling in angiogenesis. Curr Drug Targets (2008) 0.95
p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction. J Biol Chem (2010) 0.95
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies. Front Mol Neurosci (2011) 0.91
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1. Proc Natl Acad Sci U S A (2006) 0.90
Beyond cell adhesion: the role of armadillo proteins in the heart. Cell Signal (2012) 0.89
Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism. Cell Signal (2010) 0.89
Analysis of dishevelled localization and function in the early sea urchin embryo. Dev Biol (2007) 0.89
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 0.88
Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. Br J Cancer (2006) 0.88
The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell (2013) 0.88
Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev (2005) 0.87
A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem (2009) 0.87
Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer. Virchows Arch (2011) 0.86
Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. PLoS One (2013) 0.86
Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics (2009) 0.85
Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling. Mol Cell Biol (2013) 0.85
Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med (2009) 0.83
Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1). Am J Respir Cell Mol Biol (2012) 0.83
Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas. Dis Markers (2015) 0.81
Effect of different resistance-training regimens on the WNT-signaling pathway. Eur J Appl Physiol (2011) 0.80
Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells. Br J Cancer (2005) 0.80
Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.80
Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass. Sci Rep (2014) 0.78
Neural cell adhesion molecule potentiates the growth of murine melanoma via β-catenin signaling by association with fibroblast growth factor receptor and glycogen synthase kinase-3β. J Biol Chem (2011) 0.77
Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8. PLoS One (2015) 0.76
Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependent. J Biol Chem (2014) 0.76
The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development. Curr Colorectal Cancer Rep (2012) 0.76
Activation of Wnt/β-catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression. Free Radic Biol Med (2016) 0.76
Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps. Virchows Arch (2015) 0.75
Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. Mol Med Rep (2016) 0.75
Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain. Sci Rep (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
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Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev (2000) 5.71
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