Published in Am J Respir Crit Care Med on February 23, 2006
Airway mucus function and dysfunction. N Engl J Med (2010) 4.41
Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med (2011) 2.39
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am J Respir Crit Care Med (2013) 1.93
Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest (2012) 1.85
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J (2011) 1.79
A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease. PLoS One (2012) 1.64
Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials. Proc Am Thorac Soc (2007) 1.62
Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice. Am J Respir Crit Care Med (2007) 1.60
Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease. JAMA (2008) 1.51
Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD. Chest (2013) 1.32
Critical modifier role of membrane-cystic fibrosis transmembrane conductance regulator-dependent ceramide signaling in lung injury and emphysema. J Immunol (2010) 1.14
Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer. Int J Chron Obstruct Pulmon Dis (2011) 1.11
In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure. J Anal Toxicol (2008) 1.11
Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.09
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08
Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell (2012) 1.07
Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003. Free Radic Biol Med (2006) 1.06
Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. Am J Respir Crit Care Med (2006) 1.06
Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress. Infect Immun (2008) 1.05
Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells. Free Radic Biol Med (2008) 1.05
Role of oxygen availability in CFTR expression and function. Am J Respir Cell Mol Biol (2008) 1.05
Cadmium regulates the expression of the CFTR chloride channel in human airway epithelial cells. Toxicol Sci (2010) 1.04
Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir Res (2009) 1.04
COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis (2015) 1.03
Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS One (2012) 1.01
Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. Am J Respir Cell Mol Biol (2014) 1.01
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A (2013) 0.99
Resveratrol ameliorates abnormalities of fluid and electrolyte secretion in a hypoxia-Induced model of acquired CFTR deficiency. Laryngoscope (2015) 0.98
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis. Am J Respir Crit Care Med (2015) 0.97
Cigarette smoke and CFTR: implications in the pathogenesis of COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.96
Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem (2013) 0.96
Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein. Laryngoscope (2012) 0.96
Airway hydration and COPD. Cell Mol Life Sci (2015) 0.94
CFTR and lung homeostasis. Am J Physiol Lung Cell Mol Physiol (2014) 0.94
Lung disease associated with alpha1-antitrypsin deficiency. Proc Am Thorac Soc (2010) 0.94
Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease. Respir Res (2014) 0.93
Update in cystic fibrosis 2006. Am J Respir Crit Care Med (2007) 0.93
Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. J Biol Chem (2014) 0.93
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer. Cancer Lett (2010) 0.92
Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator. Expert Rev Proteomics (2010) 0.89
Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol (2015) 0.87
CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice. PLoS One (2012) 0.87
Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis. Ann Am Thorac Soc (2016) 0.87
A biophysical model for integration of electrical, osmotic, and pH regulation in the human bronchial epithelium. Biophys J (2010) 0.86
Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography. PLoS One (2013) 0.85
Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. Am J Physiol Lung Cell Mol Physiol (2013) 0.85
The unfolded protein response in lung disease. Proc Am Thorac Soc (2010) 0.85
Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis. Respir Res (2014) 0.84
Role of CFTR in epithelial physiology. Cell Mol Life Sci (2016) 0.84
CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung. Free Radic Biol Med (2012) 0.84
Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. J Biol Chem (2014) 0.84
Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts. PLoS One (2015) 0.83
Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation. PLoS One (2013) 0.83
Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction. F1000Prime Rep (2015) 0.82
The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. Am J Respir Crit Care Med (2013) 0.81
Acute effects of cigarette smoke extract on alveolar epithelial sodium channel activity and lung fluid clearance. Am J Respir Cell Mol Biol (2013) 0.81
Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels. Respir Res (2014) 0.81
Transforming growth factor-β1 and cigarette smoke inhibit the ability of β2-agonists to enhance epithelial permeability. Am J Respir Cell Mol Biol (2015) 0.81
Quantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome. Am J Respir Cell Mol Biol (2015) 0.81
Defining the accuracy of secretin pancreatic function testing in patients with suspected early chronic pancreatitis. Am J Gastroenterol (2013) 0.80
Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med (2014) 0.80
Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. Int Forum Allergy Rhinol (2014) 0.80
Recovery of Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction after Smoking Cessation. Am J Respir Crit Care Med (2015) 0.80
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res (2014) 0.80
Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case-control study. BMC Pulm Med (2014) 0.79
Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia. FASEB J (2013) 0.79
Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease. Am J Respir Crit Care Med (2015) 0.79
Nicotine alters mucin rheological properties. Am J Physiol Lung Cell Mol Physiol (2014) 0.78
Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta (2015) 0.78
Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulm Circ (2014) 0.78
Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol (2015) 0.77
Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice. PLoS One (2015) 0.77
Chlorogenic Acid Activates CFTR-Mediated Cl- Secretion in Mice and Humans: Therapeutic Implications for Chronic Rhinosinusitis. Otolaryngol Head Neck Surg (2015) 0.76
Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance. Clin Chest Med (2015) 0.76
Hydrator Therapies for Chronic Bronchitis. Lessons from Cystic Fibrosis. Ann Am Thorac Soc (2016) 0.75
CFTR polymorphisms of healthy individuals in two Chinese cities--Changchun and Nanjing. Nagoya J Med Sci (2012) 0.75
Mucociliary dysfunction in HIV and smoked substance abuse. Front Microbiol (2015) 0.75
Carvedilol binding to β2-adrenergic receptors inhibits CFTR-dependent anion secretion in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
Suppression of CFTR-mediated Cl secretion of airway epithelium in vitamin C-deficient mice. J Korean Med Sci (2011) 0.75
Augmenting autophagy for prognosis based intervention of COPD-pathophysiology. Respir Res (2017) 0.75
The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke. Am J Respir Cell Mol Biol (2017) 0.75
Formaldehyde impairs transepithelial sodium transport. Sci Rep (2016) 0.75
Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm (2016) 0.75
The Impact of Secondhand Smoke Exposure on Children with Cystic Fibrosis: A Review. Int J Environ Res Public Health (2016) 0.75
Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype. Ann Am Thorac Soc (2016) 0.75
HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus. PLoS One (2017) 0.75
The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China. J Biomed Res (2012) 0.75
Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. Respir Res (2017) 0.75
Flavored little cigar smoke induces cytotoxicity and apoptosis in airway epithelia. Cell Death Discov (2017) 0.75
Tobacco Smoke Constituents Trigger Cytoplasmic Calcium Release. Appl In Vitro Toxicol (2017) 0.75
Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol (2004) 6.35
Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med (2005) 5.51
Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat Genet (2002) 4.62
Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol (2008) 4.07
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nat Genet (2011) 3.02
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet (2013) 2.91
Shwachman-Diamond syndrome: report from an international conference. J Pediatr (2002) 1.99
Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc Natl Acad Sci U S A (2002) 1.99
Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis (2003) 1.98
Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr (2005) 1.97
β-adrenergic sweat secretion as a diagnostic test for cystic fibrosis. Am J Respir Crit Care Med (2012) 1.92
Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR. Chem Biol (2011) 1.92
Genetic modifiers of liver disease in cystic fibrosis. JAMA (2009) 1.88
Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterology (2002) 1.80
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proc Natl Acad Sci U S A (2002) 1.78
PhenCode: connecting ENCODE data with mutations and phenotype. Hum Mutat (2007) 1.75
Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res (2005) 1.72
Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest (2008) 1.57
The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis. Chest (2009) 1.56
Glucose intolerance in children with cystic fibrosis. J Pediatr (2003) 1.51
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell (2008) 1.51
Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. J Clin Invest (2007) 1.50
Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function. J Pediatr (2007) 1.48
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res (2006) 1.48
Failure of conventional strategies to improve nutritional status in malnourished adolescents and adults with cystic fibrosis. J Pediatr (2005) 1.47
Airway inflammation and infection in congenital bilateral absence of the vas deferens. Am J Respir Crit Care Med (2003) 1.44
A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. Genome Res (2008) 1.44
Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentials. Am J Respir Crit Care Med (2006) 1.44
A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Hum Mol Genet (2003) 1.40
Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Mol Pharmacol (2010) 1.36
Membrane lateral diffusion and capture of CFTR within transient confinement zones. Biophys J (2006) 1.36
Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. Dig Dis Sci (2002) 1.34
Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis. Gastroenterology (2010) 1.33
Draft consensus guidelines for diagnosis and treatment of Shwachman-Diamond syndrome. Ann N Y Acad Sci (2011) 1.33
Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers. J Physiol (2010) 1.27
Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res (2009) 1.26
Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice. PLoS Genet (2009) 1.26
Serum pancreatic enzymes define the pancreatic phenotype in patients with Shwachman-Diamond syndrome. J Pediatr (2002) 1.26
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. Nat Genet (2012) 1.26
Construct validity of a multidimensional electronic pain diary for adolescents with arthritis. Pain (2007) 1.25
Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol (2007) 1.25
Correctors of protein trafficking defects identified by a novel high-throughput screening assay. Chembiochem (2007) 1.24
Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am J Gastroenterol (2004) 1.23
Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine. Carcinogenesis (2002) 1.23
Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice. J Physiol (2007) 1.21
Oxidant stress suppresses CFTR expression. Am J Physiol Cell Physiol (2005) 1.19
Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood. Chest (2004) 1.18
Characterization of disease-associated mutations affecting an exonic splicing enhancer and two cryptic splice sites in exon 13 of the cystic fibrosis transmembrane conductance regulator gene. Hum Mol Genet (2003) 1.18
Data-driven extraction of relative reasoning rules to limit combinatorial explosion in biodegradation pathway prediction. Bioinformatics (2008) 1.17
The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinic. Epilepsia (2005) 1.17
Physiology of epithelial chloride and fluid secretion. Cold Spring Harb Perspect Med (2012) 1.16
Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. J Physiol (2012) 1.14
Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: screening efficacy and diagnostic outcomes. J Pediatr (2005) 1.14
Phosphorylation of CFTR by PKA promotes binding of the regulatory domain. EMBO J (2005) 1.14
ATP release from human airway epithelial cells studied using a capillary cell culture system. J Physiol (2002) 1.12
Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis (2002) 1.11
Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle. Am J Respir Cell Mol Biol (2008) 1.10
Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities. Hum Genet (2013) 1.10
Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. Hum Genet (2009) 1.08
The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis. Hum Genet (2005) 1.08
CAAX-box protein, prenylation process and carcinogenesis. Am J Transl Res (2009) 1.07
Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell (2012) 1.07
Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study. Exp Hematol (2002) 1.06
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice. Nephrol Dial Transplant (2004) 1.05
Trafficking of immature DeltaF508-CFTR to the plasma membrane and its detection by biotinylation. Biochem J (2009) 1.04
Investigating membrane protein dynamics in living cells. Biochem Cell Biol (2006) 1.04
Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice. Carcinogenesis (2005) 1.03
Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1beta. Mod Pathol (2008) 1.02
Suprascapular nerve reconstruction in obstetrical brachial plexus palsy: spinal accessory nerve transfer versus C5 root grafting. Plast Reconstr Surg (2011) 1.02
Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet. Dig Dis Sci (2005) 1.01
Downregulation of missing in metastasis gene (MIM) is associated with the progression of bladder transitional carcinomas. Cancer Invest (2007) 1.01
The secret life of CFTR as a calcium-activated chloride channel. J Physiol (2013) 1.01
Inhibition of lung tumorigenesis by tea. Exp Lung Res (2005) 1.00