Published in Biosci Biotechnol Biochem on November 07, 2010
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc (2002) 1.82
Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol (2007) 1.78
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem (2004) 1.54
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res (2009) 1.53
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem (2005) 1.52
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc (2005) 1.40
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene (2003) 1.26
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
Mutasynthesis of enterocin and wailupemycin analogues. J Am Chem Soc (2003) 1.16
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol (2012) 0.97
Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. J Nat Prod (2002) 0.96
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol (2010) 0.95
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. J Nat Prod (2010) 0.94
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format. J Biomol Screen (2009) 0.94
Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023. J Antibiot (Tokyo) (2013) 0.93
Anti-influenza virus compound from Streptomyces sp. RI18. Org Lett (2010) 0.92
Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neurosci Res (2009) 0.92
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol (2010) 0.91
Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f26111. J Antibiot (Tokyo) (2013) 0.91
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp. Int J Syst Evol Microbiol (2010) 0.90
Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells. J Med Food (2007) 0.90
Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp. J Antibiot (Tokyo) (2004) 0.89
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria. FEMS Microbiol Lett (2009) 0.89
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. Toxicology (2006) 0.89
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway. J Nat Prod (2011) 0.88
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities. J Antibiot (Tokyo) (2007) 0.88
JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19. J Antibiot (Tokyo) (2010) 0.88
Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression. Org Lett (2007) 0.87
New angucycline C-glycosides from Streptomyces sp. RI33. J Antibiot (Tokyo) (2011) 0.87
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26. J Nat Prod (2010) 0.86
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge. J Antibiot (Tokyo) (2009) 0.86
Structure of aspochalasin H, a new member of the aspochalasin family. J Antibiot (Tokyo) (2002) 0.85
Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36. J Antibiot (Tokyo) (2011) 0.85
New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1. J Antibiot (Tokyo) (2009) 0.84
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78. Biol Pharm Bull (2006) 0.84
Oximidines I and II: Novel Antitumor Macrolides from Pseudomonas sp. J Org Chem (1999) 0.84
JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27. Org Lett (2009) 0.83
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph. FEMS Yeast Res (2012) 0.83
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571. J Antibiot (Tokyo) (2009) 0.83
Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin. Toxicon (2009) 0.83
JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3. J Nat Prod (2010) 0.83
Identification and biosynthesis of new acyloins from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T). Chembiochem (2014) 0.83
New tensidols, JBIR-86 and JBIR-87, isolated from Aspergillus sp. fJ80. J Antibiot (Tokyo) (2010) 0.82
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator. Org Lett (2007) 0.82
JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03. J Nat Prod (2011) 0.82
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase. Cancer Res (2003) 0.81
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. J Cell Physiol (2008) 0.81
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55. J Antibiot (Tokyo) (2009) 0.81
Isolation of a novel macrocyclic dilactone-JBIR-101-from Promicromonospora sp. RL26. J Antibiot (Tokyo) (2011) 0.80
Total synthesis and stereochemistry revision of mannopeptimycin aglycone. J Am Chem Soc (2014) 0.80
Neuroprotective effects of SG-168 against oxidative stress-induced apoptosis in PC12 cells. J Med Food (2010) 0.79
A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6. J Antibiot (Tokyo) (2008) 0.79
JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07. J Nat Prod (2012) 0.79
Terpenoids produced by actinomycetes: isolation, structural elucidation and biosynthesis of new diterpenes, gifhornenolones A and B from Verrucosispora gifhornensis YM28-088. J Antibiot (Tokyo) (2010) 0.79
Isolation of 2 new metabolites, JBIR-74 and JBIR-75, from the sponge-derived Aspergillus sp. fS14. J Antibiot (Tokyo) (2010) 0.79
Napyradiomycin A1, an inhibitor of mitochondrial complexes I and II. J Antibiot (Tokyo) (2012) 0.79
JBIR-58, a new salicylamide derivative, isolated from a marine sponge-derived Streptomyces sp. SpD081030ME-02. J Antibiot (Tokyo) (2010) 0.79
New species of actinomycetes do not always produce new compounds with high frequency. J Antibiot (Tokyo) (2011) 0.78
Origins of oxygen atoms in a marine ladder-frame polyether: evidence of monooxygenation by 18O-labeling and using tandem mass spectrometry. J Org Chem (2012) 0.78
Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole. Org Biomol Chem (2010) 0.78
Glycerol affects the acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus MSl2210. Microbiol Res (2007) 0.78
JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea. J Antibiot (Tokyo) (2009) 0.78
JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047. Biosci Biotechnol Biochem (2013) 0.78
Pleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae. Appl Environ Microbiol (2012) 0.78
Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23. J Nat Prod (2010) 0.78
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A. Eur J Med Chem (2013) 0.77
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis. Angew Chem Int Ed Engl (2015) 0.77
A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55. J Antibiot (Tokyo) (2008) 0.77
Cation involvement in telomestatin binding to g-quadruplex DNA. J Nucleic Acids (2010) 0.77
A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55. J Antibiot (Tokyo) (2007) 0.77
Antioxidant activity of propofol and related monomeric and dimeric compounds. Chem Pharm Bull (Tokyo) (2005) 0.77
Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene. Appl Microbiol Biotechnol (2009) 0.77
JBIR-65, a new diterpene, isolated from a sponge-derived Actinomadura sp. SpB081030SC-15. J Antibiot (Tokyo) (2010) 0.76
Construction of a natural product library containing secondary metabolites produced by actinomycetes. J Antibiot (Tokyo) (2012) 0.76
Major carotenoid isolated from Paracoccus schoinia NBRC 100637T is adonixanthin diglucoside. J Nat Prod (2006) 0.76
Studies on terpenoids produced by actinomycetes. Isolation and structural elucidation of antioxidative agents, naphterpins B and C. J Antibiot (Tokyo) (2005) 0.76
Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem (2011) 0.76
JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. J Antibiot (Tokyo) (2009) 0.76