Published in Curr Biol on August 20, 2002
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev (2011) 5.26
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol (2006) 3.11
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol (2006) 2.47
Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (2007) 2.22
Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A (2004) 2.11
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
Hypoxia. 2. Hypoxia regulates cellular metabolism. Am J Physiol Cell Physiol (2010) 2.03
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J (2003) 2.02
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med (2011) 1.93
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol (2004) 1.88
Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A (2012) 1.83
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol (2006) 1.76
Functions of AMP-activated protein kinase in adipose tissue. J Physiol (2006) 1.70
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
Nutrient sensing, metabolism, and cell growth control. Mol Cell (2013) 1.67
AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem (2009) 1.55
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol (2005) 1.47
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) (2009) 1.43
Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res (2009) 1.42
Effects of AMP-activated protein kinase in cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.40
Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer (2009) 1.38
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol (2010) 1.32
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. Cancer Res (2010) 1.23
A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions. J Physiol (2009) 1.23
The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. PLoS One (2011) 1.20
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass. Cell Signal (2011) 1.20
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18
Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise. J Physiol (2006) 1.17
The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell Mol Life Sci (2009) 1.16
Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle. J Physiol (2006) 1.16
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol (2011) 1.15
AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol (2008) 1.14
Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life (2009) 1.14
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis. PLoS Pathog (2012) 1.14
Regulation of mRNA translation by signaling pathways. Cold Spring Harb Perspect Biol (2012) 1.13
Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol Biol Cell (2012) 1.13
Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. Mol Cell Endocrinol (2012) 1.12
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol (2007) 1.11
Isolation of AMP-activated protein kinase (AMPK) alleles required for neuronal maintenance in Drosophila melanogaster. Biol Open (2013) 1.09
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol Cell Biol (2012) 1.05
Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Mol Cancer (2008) 1.04
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. Am J Physiol Endocrinol Metab (2011) 1.04
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J (2012) 1.03
Energy disruptors: rising stars in anticancer therapy? Oncogenesis (2016) 1.02
Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise. Eur J Appl Physiol (2008) 1.01
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem (2011) 1.00
AMP-activated protein kinase suppresses the in vitro and in vivo proliferation of hepatocellular carcinoma. PLoS One (2014) 0.98
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. Rev Diabet Stud (2009) 0.98
Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2011) 0.97
Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol (2010) 0.96
Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β. J Neurosci (2014) 0.94
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem (2009) 0.94
AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation. J Neurochem (2007) 0.93
Regulation of AMPK by the ubiquitin proteasome system. Am J Pathol (2010) 0.92
Mitochondrial Ca(2+) signals in autophagy. Cell Calcium (2012) 0.92
Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells. PLoS One (2012) 0.91
Surviving hypoxia by modulation of mRNA translation rate. J Cell Mol Med (2009) 0.91
Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radic Biol Med (2007) 0.90
Resveratrol and the eye: activity and molecular mechanisms. Graefes Arch Clin Exp Ophthalmol (2014) 0.90
Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle. Pflugers Arch (2007) 0.89
Proteomic analysis of anoxia tolerance in the developing zebrafish embryo. Comp Biochem Physiol Part D Genomics Proteomics (2008) 0.89
AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis. Mol Biol Cell (2011) 0.87
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia. J Biol Chem (2012) 0.86
Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells. PLoS One (2015) 0.86
The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. J Clin Invest (2014) 0.86
Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. J Cell Mol Med (2014) 0.86
Knockdown of AMP-activated protein kinase alpha 1 and alpha 2 catalytic subunits. J RNAi Gene Silencing (2012) 0.86
Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia. Mol Cell Biol (2015) 0.85
Global protein synthesis in human trophoblast is resistant to inhibition by hypoxia. Placenta (2011) 0.85
Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. J Appl Physiol (1985) (2006) 0.84
Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase. J Cell Biochem (2008) 0.84
Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int J Mol Sci (2016) 0.83
Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system. Mol Endocrinol (2014) 0.83
Cytoplasmic signaling in the control of mitochondrial uproar? Cell Commun Signal (2008) 0.81
Ambient hypoxia enhances the loss of muscle mass after extensive injury. Pflugers Arch (2013) 0.81
Oncogenes strike a balance between cellular growth and homeostasis. Semin Cell Dev Biol (2015) 0.81
Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers. PLoS One (2013) 0.81
Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase. Exp Mol Med (2011) 0.80
Training in the fasted state facilitates re-activation of eEF2 activity during recovery from endurance exercise. Eur J Appl Physiol (2010) 0.80
Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. World J Biol Chem (2012) 0.80
AMPK: a master energy regulator for gonadal function. Front Neurosci (2015) 0.79
Facilitation of rice stripe virus accumulation in the insect vector by Himetobi P virus VP1. Viruses (2015) 0.79
AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding. Biophys J (2012) 0.79
Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation. Sci Rep (2016) 0.79
Adenosine monophosphate-activated protein kinase in diabetic nephropathy. Kidney Res Clin Pract (2016) 0.78
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells. Invest New Drugs (2016) 0.78
Role of AMP-activated protein kinase in metabolic depression in animals. J Comp Physiol B (2015) 0.77
Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2. J Comp Neurol (2013) 0.77
AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts. Oncotarget (2015) 0.77
Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis. Am J Physiol Endocrinol Metab (2015) 0.77
Role of PFKFB3-driven glycolysis in vessel sprouting. Cell (2013) 3.04
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol (2006) 2.47
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J (2003) 2.11
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab (2005) 2.04
Targeting Mnks for cancer therapy. Oncotarget (2012) 1.96
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem (2002) 1.78
A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J Am Soc Nephrol (2003) 1.77
Identification of a dehydrogenase acting on D-2-hydroxyglutarate. Biochem J (2004) 1.72
Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur J Biochem (2003) 1.69
Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria. Mol Microbiol (2012) 1.61
PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli. Biochem J (2013) 1.60
Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery: insight from a prospective randomized trial. Eur J Cardiothorac Surg (2011) 1.47
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem J (2004) 1.45
ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer. Int J Cancer (2012) 1.43
A periplasmic reducing system protects single cysteine residues from oxidation. Science (2009) 1.42
Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett (2002) 1.41
Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization. Biophys J (2004) 1.40
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem (2002) 1.38
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside. Biochem J (2007) 1.30
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res (2011) 1.24
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J (2005) 1.23
H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart. Circ Res (2005) 1.19
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem (2008) 1.19
Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A (2008) 1.18
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology (2012) 1.16
Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life (2009) 1.14
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. Am J Physiol Heart Circ Physiol (2006) 1.14
Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1). J Biol Chem (2010) 1.14
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14
Control of mammalian gene expression by amino acids, especially glutamine. FEBS J (2009) 1.13
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Eur J Biochem (2002) 1.12
Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans. Microb Pathog (2006) 1.11
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol (2006) 1.11
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. J Biol Chem (2011) 1.10
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem (2003) 1.10
High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites. J Mol Biol (2006) 1.08
Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. Am J Physiol Heart Circ Physiol (2006) 1.04
The protein-disulfide isomerase DsbC cooperates with SurA and DsbA in the assembly of the essential β-barrel protein LptD. J Biol Chem (2010) 1.03
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity. J Biol Chem (2005) 1.03
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J (2012) 1.03
Identification of peptidases in Nicotiana tabacum leaf intercellular fluid. Proteomics (2008) 1.02
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways. J Mol Cell Cardiol (2002) 1.02
Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. Biochim Biophys Acta (2008) 1.01
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovasc Res (2011) 1.01
Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system. Infect Immun (2003) 1.01
Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. J Biol Chem (2004) 1.01
Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion. Am J Physiol Heart Circ Physiol (2007) 0.99
Glutamine stimulates argininosuccinate synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells. J Biol Chem (2003) 0.99
Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family. J Biol Chem (2007) 0.98
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. Am J Physiol Endocrinol Metab (2010) 0.98
Osmotic stress, a proinflammatory signal in Caco-2 cells. Biochimie (2004) 0.98
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states. Am J Physiol Heart Circ Physiol (2013) 0.97
AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. Biochem Biophys Res Commun (2010) 0.97
Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes. Diabetes Metab Res Rev (2010) 0.97
Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction. Eur Heart J (2005) 0.96
Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei. Biochim Biophys Acta (2007) 0.96
Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun (2009) 0.95
IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA. Am J Physiol Endocrinol Metab (2006) 0.95
Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1. Cell Transplant (2007) 0.94
Crystal structure of the outer membrane protein RcsF, a new substrate for the periplasmic protein-disulfide isomerase DsbC. J Biol Chem (2011) 0.94
Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake. Am J Physiol Endocrinol Metab (2008) 0.94
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J (2012) 0.94
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase. Glycobiology (2005) 0.94
Contribution of proteomics toward solving the fascinating mysteries of the biogenesis of the envelope of Escherichia coli. Proteomics (2010) 0.93
Glutamine and interleukin-1beta interact at the level of Sp1 and nuclear factor-kappaB to regulate argininosuccinate synthetase gene expression. FEBS J (2007) 0.93
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes. FEBS Lett (2008) 0.93
ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1. PLoS One (2011) 0.93
IL-1beta stimulates argininosuccinate synthetase gene expression through NF-kappaB in Caco-2 cells. Biochimie (2005) 0.92
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK. Cell Signal (2007) 0.92
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. Am J Physiol Endocrinol Metab (2014) 0.91
Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. J Biol Chem (2011) 0.91
Increased protein glycation in fructosamine 3-kinase-deficient mice. Biochem J (2006) 0.91
Dissecting the machinery that introduces disulfide bonds in Pseudomonas aeruginosa. MBio (2013) 0.90
Myocardial injury induced by ultrasound-targeted microbubble destruction: evidence for the contribution of myocardial ischemia. Ultrasound Med Biol (2008) 0.90
The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia. Cardiovasc Res (2007) 0.89