Published in Zhong Nan Da Xue Xue Bao Yi Xue Ban on November 01, 2010
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89
The specific and essential role of MAVS in antiviral innate immune responses. Immunity (2006) 6.74
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell (2010) 5.83
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med (2014) 5.37
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature (2012) 5.02
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 4.65
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell (2012) 4.41
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51
The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet (2013) 3.43
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood (2011) 3.40
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA (2012) 2.49
Quantitative measurement of interocular suppression in anisometropic amblyopia: a case-control study. Ophthalmology (2013) 2.17
Electronic signatures of all four DNA nucleosides in a tunneling gap. Nano Lett (2010) 1.83
Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Circ Res (2006) 1.79
Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus. J Rheumatol (2010) 1.78
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A (2008) 1.74
Localization and pharmacological modulation of GABA-B receptors in the globus pallidus of parkinsonian monkeys. Exp Neurol (2011) 1.66
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife (2013) 1.63
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol (2009) 1.57
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer (2002) 1.56
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project. Blood (2012) 1.47
A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res (2006) 1.46
Retroperitoneal laparoscopic dismembered pyeloplasty with a novel technique of JJ stenting in children. BJU Int (2011) 1.45
Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one-year results. Invest Ophthalmol Vis Sci (2011) 1.41
scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. Cancer Biol Ther (2008) 1.40
CD147/basigin promotes progression of malignant melanoma and other cancers. J Dermatol Sci (2010) 1.29
Wnt signaling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskelet Dis (2013) 1.25
Improvement of Aspergillus sulphureus endo-beta-1,4-xylanase expression in Pichia pastoris by codon optimization and analysis of the enzymic characterization. Appl Biochem Biotechnol (2009) 1.22
HRT1 modulates vascular smooth muscle cell proliferation and apoptosis. Biochem Biophys Res Commun (2003) 1.22
miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B. J Bone Miner Res (2013) 1.21
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2008) 1.16
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett (2008) 1.16
Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. Int Immunopharmacol (2011) 1.14
Spectacle lenses designed to reduce progression of myopia: 12-month results. Optom Vis Sci (2010) 1.13
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Hum Reprod (2010) 1.13
Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential. PLoS One (2012) 1.11
Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model. Arterioscler Thromb Vasc Biol (2006) 1.11
RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett (2008) 1.10
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2009) 1.09
Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. J Mol Biol (2007) 1.09
Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13. Exp Toxicol Pathol (2010) 1.09
Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). PLoS One (2009) 1.09
A sign-component-based framework for Chinese sign language recognition using accelerometer and sEMG data. IEEE Trans Biomed Eng (2012) 1.08
Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells. J Bone Miner Res (2012) 1.08
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines. BMC Proc (2009) 1.08
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem (2006) 1.07
Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Mol Vis (2007) 1.06
Maximal conditional chi-square importance in random forests. Bioinformatics (2010) 1.04
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. BMC Cancer (2011) 1.04
The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic Physiol Opt (2009) 1.02
miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1α. Cancer Biol Ther (2015) 1.00
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry (2009) 1.00
Willows: a memory efficient tree and forest construction package. BMC Bioinformatics (2009) 1.00
Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity. Exp Mol Med (2008) 1.00
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci (2012) 0.99
Prevalence of virulence factors and antimicrobial resistance of uropathogenic Escherichia coli in Jiangsu province (China). Urology (2009) 0.99
Acupuncture for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev (2011) 0.98
Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. Biomaterials (2011) 0.97
Position-specific analysis and prediction for protein lysine acetylation based on multiple features. PLoS One (2012) 0.96
MicroRNA-17-92 cluster regulates osteoblast proliferation and differentiation. Endocrine (2013) 0.96
RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget (2014) 0.96
Depletion of CD147 sensitizes human malignant melanoma cells to hydrogen peroxide-induced oxidative stress. J Dermatol Sci (2010) 0.96
An improved method to knock out the asd gene of Salmonella enterica serovar Pullorum. J Biomed Biotechnol (2009) 0.95
Nasopharyngeal carcinoma: advances in genomics and molecular genetics. Sci China Life Sci (2011) 0.95
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data. Genome Biol (2012) 0.95
Proteomic and bioinformatic analysis on endocrine organs of domesticated silkworm, Bombyx mori L. for a comprehensive understanding of their roles and relations. J Proteome Res (2009) 0.95
Automatic registration of CT volumes and dual-energy digital radiography for detection of cardiac and lung diseases. Conf Proc IEEE Eng Med Biol Soc (2006) 0.95
Refractive shifts in four selected artificial vitreous substitutes based on Gullstrand-Emsley and Liou-Brennan schematic eyes. Invest Ophthalmol Vis Sci (2009) 0.95
IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma. Cancer Lett (2013) 0.94
Myopia progression in Chinese children is slower in summer than in winter. Optom Vis Sci (2012) 0.94
Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models. Phytother Res (2008) 0.94
A local average connectivity-based method for identifying essential proteins from the network level. Comput Biol Chem (2011) 0.94
Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme. J Cell Sci (2005) 0.93
Distribution of adenosine receptors in human sclera fibroblasts. Mol Vis (2008) 0.93
Ambulatory monitoring of human posture and walking speed using wearable accelerometer sensors. Conf Proc IEEE Eng Med Biol Soc (2008) 0.93
Antitumor and antimetastatic activities of vesicular stomatitis virus matrix protein in a murine model of breast cancer. J Mol Med (Berl) (2009) 0.93
In vivo optogenetic control of striatal and thalamic neurons in non-human primates. PLoS One (2012) 0.92
Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochem Pharmacol (2010) 0.92
Step counter use in type 2 diabetes: a meta-analysis of randomized controlled trials. BMC Med (2014) 0.92
Aquaporin-3 gene and protein expression in sun-protected human skin decreases with skin ageing. Australas J Dermatol (2010) 0.92
Conditional immortalization establishes a repertoire of mouse melanocyte progenitors with distinct melanogenic differentiation potential. J Invest Dermatol (2012) 0.92
Optimizing high-performance liquid chromatography method for quantification of glucosamine using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatization in rat plasma: application to a pharmacokinetic study. Biomed Chromatogr (2008) 0.91
An NAC transcription factor controls ethylene-regulated cell expansion in flower petals. Plant Physiol (2013) 0.91
Activation of the integrins alpha 5beta 1 and alpha v beta 3 and focal adhesion kinase (FAK) during arteriogenesis. Mol Cell Biochem (2008) 0.91
Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent. Biomaterials (2011) 0.91
Peripheral defocus with single-vision spectacle lenses in myopic children. Optom Vis Sci (2010) 0.91
Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur J Clin Pharmacol (2010) 0.91
Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Mol Cancer Ther (2013) 0.91
Treatment of symptomatic primary obstructive megaureter by laparoscopic intracorporeal or extracorporeal ureteral tapering and ureteroneocystostomy: experience on 11 patients. J Endourol (2012) 0.91