The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3035040)

Published in Biol Psychiatry on December 16, 2010

Authors

Rodrigo Machado-Vieira1, Natalia B Pivovarova, Ruslan I Stanika, Peixiong Yuan, Yun Wang, Rulun Zhou, Carlos A Zarate, Wayne C Drevets, Christine A Brantner, Amber Baum, Gonzalo Laje, Francis J McMahon, Guang Chen, Jing Du, Husseini K Manji, S Brian Andrews

Author Affiliations

1: Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA.

Associated clinical trials:

In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects | NCT01565759

Articles citing this

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease. Cell Calcium (2011) 1.01

Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia. Prion (2012) 0.97

Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach. World J Biol Psychiatry (2013) 0.93

Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder. Expert Opin Ther Targets (2014) 0.89

Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience. Brain Res (2011) 0.88

Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder. Acta Psychiatr Scand (2012) 0.87

Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival. Proc Natl Acad Sci U S A (2014) 0.86

Upstream Pathways Controlling Mitochondrial Function in Major Psychosis: A Focus on Bipolar Disorder. Can J Psychiatry (2016) 0.84

Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder. Neuropsychopharmacology (2012) 0.84

Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia. Age (Dordr) (2011) 0.80

Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder. CNS Spectr (2013) 0.79

Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes. PLoS One (2013) 0.76

Non-apoptotic functions of BCL-2 family proteins. Cell Death Differ (2017) 0.75

Genetic variants of BCL2 gene predict clinical outcomes of non-small-cell lung cancer patients treated with platinum-based chemotherapy in a Chinese population. Am J Cancer Res (2016) 0.75

Oral treatment with herbal formula B401 alleviates penile toxicity in aging mice with manganism. Clin Interv Aging (2015) 0.75

Articles cited by this

A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20

The mesolimbic dopamine reward circuit in depression. Biol Psychiatry (2006) 7.62

Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol (2001) 7.06

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10

The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium (2003) 3.38

Calcium and neurodegeneration. Aging Cell (2007) 2.90

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol (2004) 2.87

A common mechanism of action for three mood-stabilizing drugs. Nature (2002) 2.58

Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature (1997) 2.57

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ (2008) 2.49

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol (2008) 2.44

Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron (2008) 2.40

Mitochondrial dysfunction in bipolar disorder. Bipolar Disord (2000) 2.32

Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum. Cell Death Differ (2006) 2.23

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol (2008) 2.13

The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem (1999) 2.04

Ca2+ signaling, mitochondria and cell death. Curr Mol Med (2008) 1.81

Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death. J Biol Chem (2001) 1.70

Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis. Eur J Neurosci (2005) 1.53

Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics. J Neurosci (1999) 1.42

Bcl-2 and calcium: controversy beneath the surface. Oncogene (2004) 1.36

Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett (2007) 1.35

Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis (2009) 1.35

ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid Redox Signal (2007) 1.31

Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology (2008) 1.29

Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26

Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. J Clin Psychiatry (2000) 1.18

Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood? FEBS Lett (2004) 1.16

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content. Cell Calcium (2008) 1.11

The underlying neurobiology of bipolar disorder. World Psychiatry (2003) 1.05

Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca release. J Gen Physiol (2001) 0.97

Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol (1999) 0.96

Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans. Biol Psychiatry (2009) 0.95

Molecular neurobiology of bipolar disorder: a disease of 'mood-stabilizing neurons'? Trends Neurosci (2008) 0.94

Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsychopharmacol (2008) 0.94

A potent cell death activity associated with transient high level expression of BCL-2. J Biol Chem (1998) 0.90

Chronic lithium treatment attenuates intracellular calcium mobilization. Neuropsychopharmacology (2004) 0.89

Behavioral effects of Bcl-2 deficiency: implications for affective disorders. Pharmacol Rep (2008) 0.89

Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus. Biol Psychiatry (2000) 0.87

Effects of 4-week treatment with lithium and olanzapine on levels of brain-derived neurotrophic factor, B-cell CLL/lymphoma 2 and phosphorylated cyclic adenosine monophosphate response element-binding protein in the sub-regions of the hippocampus. Basic Clin Pharmacol Toxicol (2009) 0.87

Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder. Int J Neuropsychopharmacol (2007) 0.86

Articles by these authors

Comprehensive human genome amplification using multiple displacement amplification. Proc Natl Acad Sci U S A (2002) 13.58

Interneurons of the neocortical inhibitory system. Nat Rev Neurosci (2004) 13.33

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry (2006) 11.84

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci (2008) 8.14

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry (2003) 6.93

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry (2007) 6.59

Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry (2003) 6.52

Unbiased whole-genome amplification directly from clinical samples. Genome Res (2003) 6.29

Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04

An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. Circ Cardiovasc Qual Outcomes (2008) 6.00

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission. Circ Cardiovasc Qual Outcomes (2009) 5.66

Neurocircuitry of mood disorders. Neuropsychopharmacology (2010) 5.57

National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry (2007) 5.49

An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with an acute myocardial infarction. Circulation (2006) 5.35

National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA (2011) 5.16

Discovering endophenotypes for major depression. Neuropsychopharmacology (2004) 4.90

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry (2010) 4.85

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother (2013) 4.80

An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with heart failure. Circulation (2006) 4.52

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov (2008) 4.46

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37

Trends in length of stay and short-term outcomes among Medicare patients hospitalized for heart failure, 1993-2006. JAMA (2010) 4.36

Reduction in acute myocardial infarction mortality in the United States: risk-standardized mortality rates from 1995-2006. JAMA (2009) 4.24

Association between maintenance of certification examination scores and quality of care for medicare beneficiaries. Arch Intern Med (2008) 4.20

International Society for Bipolar Disorders Task Force on Suicide: meta-analyses and meta-regression of correlates of suicide attempts and suicide deaths in bipolar disorder. Bipolar Disord (2014) 4.10

The melting Himalayas: cascading effects of climate change on water, biodiversity, and livelihoods. Conserv Biol (2009) 4.02

Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail (2009) 3.95

Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiology (2013) 3.93

Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science (2011) 3.66

National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Arch Gen Psychiatry (2006) 3.38

Standards for statistical models used for public reporting of health outcomes: an American Heart Association Scientific Statement from the Quality of Care and Outcomes Research Interdisciplinary Writing Group: cosponsored by the Council on Epidemiology and Prevention and the Stroke Council. Endorsed by the American College of Cardiology Foundation. Circulation (2005) 3.38

Recent declines in hospitalizations for acute myocardial infarction for Medicare fee-for-service beneficiaries: progress and continuing challenges. Circulation (2010) 3.32

Synaptic connections and small circuits involving excitatory and inhibitory neurons in layers 2-5 of adult rat and cat neocortex: triple intracellular recordings and biocytin labelling in vitro. Cereb Cortex (2002) 3.28

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24

Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry (2007) 3.15

High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron (2011) 3.08

Group SCAD regression analysis for microarray time course gene expression data. Bioinformatics (2007) 3.04

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02

The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence. Am J Psychiatry (2003) 3.00

Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N Engl J Med (2014) 2.99

Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry (2010) 2.98

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90

Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry (2007) 2.87

Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry (2007) 2.83

Neural circuits underlying the pathophysiology of mood disorders. Trends Cogn Sci (2011) 2.76

Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. Arch Gen Psychiatry (2006) 2.68

New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65

Defining the mammalian CArGome. Genome Res (2005) 2.59

Causes of blindness and visual impairment in urban and rural areas in Beijing: the Beijing Eye Study. Ophthalmology (2006) 2.59

Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet (2003) 2.55

Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet (2006) 2.55

Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev (2009) 2.44

Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice. J Neurosci (2006) 2.40

High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology (2006) 2.40

National patterns of risk-standardized mortality and readmission for acute myocardial infarction and heart failure. Update on publicly reported outcomes measures based on the 2010 release. Circ Cardiovasc Qual Outcomes (2010) 2.33

Dopaminergic differentiation of human embryonic stem cells. Stem Cells (2004) 2.30

The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J Neurosci (2003) 2.28

An administrative claims model for profiling hospital 30-day mortality rates for pneumonia patients. PLoS One (2011) 2.22

Ketamine for depression: where do we go from here? Biol Psychiatry (2012) 2.21

Hospital volume and 30-day mortality for three common medical conditions. N Engl J Med (2010) 2.20

Outcomes of deep anterior lamellar keratoplasty using the big-bubble technique in various corneal diseases. Am J Ophthalmol (2012) 2.20

The performance of US hospitals as reflected in risk-standardized 30-day mortality and readmission rates for medicare beneficiaries with pneumonia. J Hosp Med (2010) 2.20

Effectiveness and acceptability of a computerized decision support system using modified Wells criteria for evaluation of suspected pulmonary embolism. Ann Emerg Med (2010) 2.19

Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology (2012) 2.17

Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci (2004) 2.17

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15

Association of retail tobacco marketing with adolescent smoking. Am J Public Health (2004) 2.15

National trends in outcomes among elderly patients with heart failure. Am J Med (2006) 2.13

Regional variation in the treatment and outcomes of myocardial infarction: investigating New England's advantage. Am Heart J (2003) 2.11

Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09

Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry (2006) 2.09

Relationship between hospital readmission and mortality rates for patients hospitalized with acute myocardial infarction, heart failure, or pneumonia. JAMA (2013) 2.06

Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine. Biol Psychiatry (2008) 2.05

Just what the doctor ordered. Review of the evidence of the impact of computerized physician order entry system on medication errors. Health Serv Res (2008) 2.05

Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci STKE (2004) 2.04

Hospital-acquired pressure ulcers: results from the national Medicare Patient Safety Monitoring System study. J Am Geriatr Soc (2012) 2.03

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01

Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Arch Gen Psychiatry (2002) 2.01

Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology (2003) 1.99

5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol (2009) 1.99

Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry (2008) 1.99