The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

PubWeight™: 2.13‹?› | Rank: Top 2%

🔗 View Article (PMC 3012379)

Published in Immunity on December 14, 2010

Authors

Yanxing Yu1, Gary S Hayward

Author Affiliations

1: Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB1 3M09, Baltimore, MD 21231, USA. yyanxin1@jhmi.edu

Articles citing this

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev (2011) 1.22

Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling. J Virol (2011) 1.21

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med (2012) 1.16

Regulation of TLR7/9 signaling in plasmacytoid dendritic cells. Protein Cell (2012) 1.05

Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol Mol Biol Rev (2012) 1.04

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update. Curr Opin Virol (2013) 0.99

Negative regulatory approaches to the attenuation of Toll-like receptor signaling. Exp Mol Med (2013) 0.99

Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation. PLoS Pathog (2013) 0.98

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis. Immunity (2016) 0.97

Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies. Front Microbiol (2012) 0.97

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog (2012) 0.96

Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation. J Virol (2011) 0.95

The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates. J Biol Chem (2013) 0.93

Ubiquitination in the antiviral immune response. Virology (2015) 0.92

The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat Immunol (2015) 0.91

Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem (2011) 0.89

RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One (2013) 0.89

Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion. PLoS Pathog (2013) 0.88

TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. PLoS Pathog (2015) 0.87

Microbial strategies for antagonizing Toll-like-receptor signal transduction. Curr Opin Immunol (2015) 0.87

Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation. J Virol (2014) 0.87

Toll-like receptor sensing of human herpesvirus infection. Front Cell Infect Microbiol (2012) 0.86

Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol (2014) 0.83

FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. J Biol Chem (2013) 0.83

Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. Virology (2013) 0.83

Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy. J Clin Invest (2016) 0.82

Mechanisms and pathways of innate immune activation and regulation in health and cancer. Hum Vaccin Immunother (2014) 0.82

KSHV RTA abolishes NFκB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasome. PLoS One (2014) 0.82

Ubiquitin in the activation and attenuation of innate antiviral immunity. J Exp Med (2015) 0.81

Hul5 ubiquitin ligase: good riddance to bad proteins. Prion (2012) 0.81

Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system. Cytokine Growth Factor Rev (2014) 0.80

Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7. Sci Rep (2015) 0.80

Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5. J Innate Immun (2014) 0.79

The Ubiquitin System and Kaposi's Sarcoma-Associated Herpesvirus. Front Microbiol (2012) 0.79

CuRTAiling interferon regulatory factor signaling with the E3 ligase RAUL. Immunity (2010) 0.77

A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation. J Immunol (2016) 0.77

HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. Cell Death Dis (2014) 0.77

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. J Biol Chem (2015) 0.77

Multi-step regulation of innate immune signaling by Kaposi's sarcoma-associated herpesvirus. Virus Res (2015) 0.77

Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS One (2012) 0.77

SUMO and KSHV Replication. Cancers (Basel) (2014) 0.76

MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells. Front Immunol (2017) 0.76

Immune control of oncogenic γ-herpesviruses. Curr Opin Virol (2015) 0.76

The role of alternative polyadenylation in the antiviral innate immune response. Nat Commun (2017) 0.75

The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation. Virology (2016) 0.75

cFLIPL Interrupts IRF3-CBP-DNA Interactions To Inhibit IRF3-Driven Transcription. J Immunol (2016) 0.75

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. MBio (2017) 0.75

Effects of a Particular Heptapeptide on the IFN-α-Sensitive CML Cells. Biomed Res Int (2015) 0.75

Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus. Mol Cell Biol (2016) 0.75

Activation and degradation of open reading frame 45 by the replication and transcription activator of Kaposi's sarcoma-associated herpesvirus. J Gen Virol (2015) 0.75

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation. MBio (2016) 0.75

NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. J Exp Med (2016) 0.75

Rubicon modulates antiviral type I IFN signaling by targeting IRF3 dimerization. J Virol (2017) 0.75

Articles cited by this

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67

IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23

TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84

Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62

Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70

Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med (2001) 6.97

IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (2010) 4.03

DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (2004) 3.66

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol (2006) 2.85

Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature (2004) 2.83

IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol Cell Biol (1997) 2.70

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep (2008) 2.65

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53

A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol (2007) 2.53

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc Natl Acad Sci U S A (2002) 2.30

Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem (2000) 2.20

The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity (2005) 2.14

The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol (2008) 2.07

The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science (2005) 1.88

Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. J Virol (2007) 1.71

Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol (2002) 1.67

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J (1997) 1.65

Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. EMBO J (2006) 1.64

Keeping transcriptional activators under control. Cell (2006) 1.62

Regulation of catalytic activities of HECT ubiquitin ligases. Biochem Biophys Res Commun (2007) 1.42

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. Virology (2007) 1.40

The HERC proteins: functional and evolutionary insights. Cell Mol Life Sci (2005) 1.39

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res (2008) 1.35

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Mol Cell (2006) 1.35

A HECT domain E3 enzyme assembles novel polyubiquitin chains. J Biol Chem (2001) 1.30

A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem (2002) 1.23

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol (1998) 1.14

Turning NF-kappaB and IRFs on and off in DC. Trends Immunol (2008) 1.12

Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability. Eur J Biochem (2000) 1.09

Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. J Biol Chem (2003) 0.88

Evaluation of polymerase chain reaction, conventional and MRSA screen latex agglutination methods for detection of methicillin-resistant, -borderline and -susceptible Staphylococcus aureus. Southeast Asian J Trop Med Public Health (2004) 0.79

Articles by these authors

The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J Gen Virol (2003) 3.48

The order Herpesvirales. Arch Virol (2008) 3.41

A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med (2003) 3.10

The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity (2005) 2.14

Detection and evaluation of novel herpesviruses in routine and pathological samples from Asian and African elephants: identification of two new probosciviruses (EEHV5 and EEHV6) and two new gammaherpesviruses (EGHV3B and EGHV5). Vet Microbiol (2010) 1.78

Cytomegalovirus (CMV)-encoded UL144 (truncated tumor necrosis factor receptor) and outcome of congenital CMV infection. J Infect Dis (2006) 1.75

Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. J Virol (2002) 1.73

CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. J Virol (2003) 1.72

Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells. J Virol (2004) 1.64

Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J Virol (2003) 1.58

Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J Virol (2004) 1.51

Detection of pathogenic elephant endotheliotropic herpesvirus in routine trunk washes from healthy adult Asian elephants (Elephas maximus) by use of a real-time quantitative polymerase chain reaction assay. Am J Vet Res (2010) 1.46

Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe (2011) 1.43

Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol (2002) 1.41

Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc Natl Acad Sci U S A (2002) 1.34

CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle. J Virol (2003) 1.33

Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease. J Infect Dis (2002) 1.27

Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1). J Virol (2003) 1.26

Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. J Virol (2008) 1.25

Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. J Virol (2009) 1.21

The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht. J Gen Virol (2005) 1.19

Complete Genome Sequence of Elephant Endotheliotropic Herpesvirus 1A. Genome Announc (2013) 1.17

Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins. J Gen Virol (2004) 1.16

Kinetics of viral loads and genotypic analysis of elephant endotheliotropic herpesvirus-1 infection in captive Asian elephants (Elephas maximus). J Zoo Wildl Med (2013) 1.12

CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during induction of the EBV lytic cycle. J Virol (2004) 1.07

Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells. J Virol (2006) 1.06

Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol (2009) 1.06

Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism. J Clin Virol (2002) 1.05

Ugandan Kaposi's sarcoma-associated herpesvirus phylogeny: evidence for cross-ethnic transmission of viral subtypes. Intervirology (2006) 1.02

Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors. Virol J (2011) 1.01

Conservation: clarifying the risk from herpesvirus to captive Asian elephants. Vet Rec (2012) 0.99

Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive Asian elephants (Elephas maximus). J Zoo Wildl Med (2013) 0.99

Fatal herpesvirus hemorrhagic disease in wild and orphan asian elephants in southern India. J Wildl Dis (2013) 0.98

Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology (2009) 0.96

Development and validation of quantitative real-time polymerase chain reaction assays to detect elephant endotheliotropic herpesviruses-2, 3, 4, 5, and 6. J Virol Methods (2012) 0.95

Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray. J Infect Dis (2011) 0.93

KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol (2011) 0.92

Fatal elephant endotheliotropic herpesvirus type 5 infection in a captive Asian elephant. Vet Rec (2012) 0.91

CLINICAL INFECTION OF CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 4. J Zoo Wildl Med (2016) 0.90

Reflections on the interpretation of heterogeneity and strain differences based on very limited PCR sequence data from Kaposi's sarcoma-associated herpesvirus genomes. J Clin Virol (2007) 0.86

KSHV downregulation of galectin-3 in Kaposi's sarcoma. Glycobiology (2009) 0.85

Complete genome sequence of the english isolate of rat cytomegalovirus (Murid herpesvirus 8). J Virol (2012) 0.85

Detection of a single identical cytomegalovirus (CMV) strain in recently seroconverted young women. PLoS One (2011) 0.83

Deletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency. J Gen Virol (2009) 0.81

Evaluation of global clustering patterns and strain variation over an extended ORF26 gene locus from Kaposi's sarcoma herpesvirus. J Clin Virol (2007) 0.81

Rat cytomegalovirus (RCMV) English isolate and a newly identified Berlin isolate share similarities with but are separate as an anciently diverged clade from Mouse CMV and the Maastricht isolate of RCMV. J Gen Virol (2015) 0.79

EPIDEMIOLOGIC EVALUATION OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 3B INFECTION IN AN AFRICAN ELEPHANT (LOXODONTA AFRICANA). J Zoo Wildl Med (2017) 0.75