Published in Science on February 26, 2010
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NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. PLoS Pathog (2010) 1.16
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Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response. PLoS Pathog (2013) 1.15
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Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathog (2013) 1.07
Regulation of NF-κB by TNF family cytokines. Semin Immunol (2014) 1.06
Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2013) 1.05
SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem (2010) 1.05
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05
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The TLR and IL-1 signalling network at a glance. J Cell Sci (2014) 1.01
Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. Cell Mol Life Sci (2011) 1.01
Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00
O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice. PLoS One (2010) 1.00
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TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. PLoS One (2011) 0.98
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Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death. J Biol Chem (2012) 0.96
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A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog (2012) 0.96
ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol (2013) 0.95
ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem (2011) 0.95
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An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. J Virol (2012) 0.94
A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS One (2011) 0.94
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Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology (2015) 0.88
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Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. Elife (2015) 0.86
Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination. Virology (2013) 0.86
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling. J Neuroinflammation (2012) 0.86
RIP kinase-mediated necrosis as an alternative mechanisms of photoreceptor death. Oncotarget (2011) 0.85
Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway. Sci Rep (2013) 0.85
miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas. Cell Death Dis (2014) 0.85
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STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun (2014) 0.85
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β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation. Mol Cell Biol (2012) 0.85
A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem (2011) 0.84
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC. PLoS One (2012) 0.84
Expression of A20 is reduced in pancreatic cancer tissues. J Mol Histol (2012) 0.84
A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression. Mol Cancer (2015) 0.84
Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of Sphingolipids. J Immunol (2015) 0.83
Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20. PLoS One (2015) 0.83
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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature (2009) 7.37
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89
Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 4.65
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33
Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 4.22
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Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun (2008) 3.48
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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
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IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med (2008) 2.33
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ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature (2008) 1.72
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TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy (2015) 0.91
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Planar microdevices for enhanced in vivo retention and oral bioavailability of poorly permeable drugs. Adv Healthc Mater (2014) 0.80
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IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation. Cell Mol Immunol (2011) 0.76
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