Published in Nature on March 31, 2002
Modes of p53 regulation. Cell (2009) 9.31
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17
Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature (2004) 2.83
Ubiquitin, hormones and biotic stress in plants. Ann Bot (2007) 2.77
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics. Nat Cell Biol (2005) 2.62
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J (2004) 2.50
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol (2005) 2.49
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15
The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3. Immunity (2010) 2.13
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07
Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem (2008) 2.07
Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep (2003) 1.90
The multiple levels of regulation by p53 ubiquitination. Cell Death Differ (2010) 1.87
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell (2012) 1.79
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. EMBO J (2005) 1.76
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol (2007) 1.76
The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73
Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat Genet (2012) 1.63
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.62
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Mol Cell Biol (2003) 1.59
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59
VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. EMBO Rep (2005) 1.57
Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins. Genes Dev (2007) 1.57
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A (2007) 1.56
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol Cell Biol (2004) 1.54
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. J Virol (2005) 1.54
The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene (2007) 1.54
The MDM2-p53 pathway revisited. J Biomed Res (2013) 1.52
p53 regulation by ubiquitin. FEBS Lett (2011) 1.51
Inactivation of HAUSP in vivo modulates p53 function. Oncogene (2009) 1.48
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol (2008) 1.44
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol Cell Biol (2004) 1.44
53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell (2016) 1.44
Deubiquitinating enzymes as novel anticancer targets. Future Oncol (2007) 1.43
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J (2008) 1.37
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol (2014) 1.35
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res (2011) 1.32
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A (2012) 1.32
Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31
Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog (2008) 1.31
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun (2014) 1.31
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J (2010) 1.28
JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. EMBO J (2011) 1.28
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol Cell Biol (2003) 1.25
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24
Mdm2 induces mono-ubiquitination of FOXO4. PLoS One (2008) 1.22
The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic (2008) 1.22
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc Natl Acad Sci U S A (2004) 1.21
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7. Nat Chem Biol (2012) 1.20
CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. Mol Cell Biol (2007) 1.20
Deubiquitylating enzymes and disease. BMC Biochem (2008) 1.17
EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog (2009) 1.16
Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells. Nat Commun (2013) 1.16
USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Biol Chem (2009) 1.14
TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol (2010) 1.13
Versatile functions of p53 protein in multicellular organisms. Biochemistry (Mosc) (2007) 1.11
Epitope tagging of endogenous genes in diverse human cell lines. Nucleic Acids Res (2008) 1.09
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08
MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation. Am J Physiol Renal Physiol (2008) 1.08
Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2003) 1.08
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. J Virol (2010) 1.08
Updates on p53: modulation of p53 degradation as a therapeutic approach. Br J Cancer (2008) 1.07
The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Genetics (2008) 1.07
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer. Cancer Discov (2012) 1.07
The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ (2011) 1.07
New insights into p53 activation. Cell Res (2010) 1.06
Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06
TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene (2010) 1.06
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A (2012) 1.06
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol (2014) 1.06
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem (2013) 1.05
Back to your heart: ubiquitin proteasome system-regulated signal transduction. J Mol Cell Cardiol (2011) 1.05
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04
A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol (2006) 1.04
Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11β-hydroxysteroid dehydrogenase 1. Diabetes (2012) 1.04
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Proc Natl Acad Sci U S A (2009) 1.03
Deubiquitylating enzymes and DNA damage response pathways. Cell Biochem Biophys (2013) 1.03
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner. J Virol (2004) 1.02
Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocr Relat Cancer (2015) 1.02
Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination. Mol Cell Biol (2004) 1.02
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11
Modes of p53 regulation. Cell (2009) 9.31
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell (2002) 4.57
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell (2006) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell (2004) 2.95
Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol (2008) 2.88
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev (2002) 2.60
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell (2008) 2.53
Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50
N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell (2003) 2.47
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell (2004) 2.46
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem (2007) 2.31
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 2.25
Cohesin acetylation speeds the replication fork. Nature (2009) 2.23
The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem (2007) 2.20
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00
Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A (2003) 1.90
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood (2011) 1.86
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86
VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A (2005) 1.84
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem (2005) 1.77
SnapShot: p53 posttranslational modifications. Cell (2008) 1.75
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol (2005) 1.74
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem (2004) 1.74
A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol (2004) 1.73
Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A (2010) 1.72
Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc Natl Acad Sci U S A (2009) 1.71
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71
ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70
Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70
Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70