Published in J Pathol on November 23, 2010
Retracted IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. J Biol Chem (2011) 1.47
PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics. J Cell Physiol (2012) 1.35
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A (2013) 1.09
Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients. Carcinogenesis (2012) 0.83
Oncogenes associated with drug resistance in ovarian cancer. J Cancer Res Clin Oncol (2014) 0.82
Decreased expression of the augmenter of liver regeneration results in increased apoptosis and oxidative damage in human-derived glioma cells. Cell Death Dis (2012) 0.78
Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways. Oncogenesis (2013) 0.78
Regulation of IKKε Expression by Akt2 Isoform. Genes Cancer (2011) 0.76
Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder. Brain Behav (2015) 0.75
IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro. Med Sci Monit (2015) 0.75
IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis. Cancer Res (2017) 0.75
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Echinococcosis. Lancet (2003) 6.83
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J Chromatogr A (2006) 4.62
Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science (2006) 4.38
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood (2010) 4.33
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15
[Human natural infection of Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2006) 3.99
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63
The role of geography in human adaptation. PLoS Genet (2009) 3.41
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med (2008) 3.33
IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest (2007) 3.31
Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat Protoc (2008) 3.24
Retracted Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). Science (2002) 3.15
Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol (2012) 3.08
Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res (2008) 3.04
Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs. Hepatology (2012) 3.04
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature (2004) 3.00
Genome-wide measurement of RNA folding energies. Mol Cell (2012) 2.85
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol (2007) 2.77
Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev (2003) 2.77
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76
Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet (2008) 2.71
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Conservation of the metabolomic response to starvation across two divergent microbes. Proc Natl Acad Sci U S A (2006) 2.68
Brain anatomical network and intelligence. PLoS Comput Biol (2009) 2.68
Surveillance of demographic characteristics and health behaviors among adult cancer survivors--Behavioral Risk Factor Surveillance System, United States, 2009. MMWR Surveill Summ (2012) 2.57
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol Psychiatry (2004) 2.53
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology (2004) 2.48
Secondhand smoke exposure among women and children: evidence from 31 countries. Am J Public Health (2008) 2.37
Basis set exchange: a community database for computational sciences. J Chem Inf Model (2007) 2.37
Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. Arthritis Rheum (2011) 2.33
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest (2014) 2.31
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
West Nile virus. Lancet Neurol (2007) 2.26
Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22
The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg (2002) 2.20
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun (2005) 2.18
A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 2.17
Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol (2013) 2.16
Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15
Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) (2010) 2.15
IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol (2010) 2.12
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10
High rate of chimeric gene origination by retroposition in plant genomes. Plant Cell (2006) 2.08
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol (2006) 2.06
IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol (2010) 2.03
Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect (2007) 2.03
Early millet use in northern China. Proc Natl Acad Sci U S A (2012) 2.01
The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis. Saudi Med J (2013) 2.01
Characterizing the admixed African ancestry of African Americans. Genome Biol (2009) 2.01
Growth of epitaxial nanowires at the junctions of nanowalls. Science (2003) 1.99
Single-atom catalysis of CO oxidation using Pt1/FeOx. Nat Chem (2011) 1.98
IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J Biol Chem (2002) 1.94
Phenotypic clustering in MPZ mutations. Brain (2004) 1.94
The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation. Plant Biotechnol J (2014) 1.93
Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity. Genome Res (2008) 1.92
The White test: a new dye test for intraoperative detection of bile leakage during major liver resection. Arch Surg (2008) 1.86
Isolated coronary artery bypass graft combined with bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: a single-center, randomized, double-blind, placebo-controlled clinical trial. J Am Coll Cardiol (2011) 1.85
Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis (2009) 1.85
Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl (2009) 1.84
Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol (2010) 1.83
Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells. J Pathol (2010) 1.82
Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem (2004) 1.80
A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science (2012) 1.78
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol (2010) 1.77
MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76
Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity. J Bacteriol (2010) 1.76
The effects of cardiopulmonary bypass on the number of cerebral microemboli and the incidence of cognitive dysfunction after coronary artery bypass graft surgery. Anesth Analg (2009) 1.74