Published in Science on April 28, 2006
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science (2007) 4.03
Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog (2009) 3.71
Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science (2011) 3.19
A global network for investigating the genomic epidemiology of malaria. Nature (2008) 3.16
How to make evolution-proof insecticides for malaria control. PLoS Biol (2009) 3.03
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS Genet (2008) 2.90
Caspar controls resistance to Plasmodium falciparum in diverse anopheline species. PLoS Pathog (2009) 2.61
Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Science (2009) 2.54
Anopheles and Plasmodium: from laboratory models to natural systems in the field. EMBO Rep (2006) 2.25
Immunity in a variable world. Philos Trans R Soc Lond B Biol Sci (2009) 2.16
Mosquito immune defenses against Plasmodium infection. Dev Comp Immunol (2009) 2.04
Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species. PLoS Pathog (2009) 1.87
Malaria control with transgenic mosquitoes. PLoS Med (2009) 1.83
Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel. Int J Parasitol (2006) 1.67
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Science (2009) 1.63
Introduction. Ecological immunology. Philos Trans R Soc Lond B Biol Sci (2009) 1.58
Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes. Proc Natl Acad Sci U S A (2012) 1.58
Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. PLoS One (2008) 1.55
Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. PLoS Pathog (2008) 1.53
Native microbiota shape insect vector competence for human pathogens. Cell Host Microbe (2011) 1.46
Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Proc Natl Acad Sci U S A (2006) 1.43
Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. PLoS One (2015) 1.42
A New Role of the Mosquito Complement-like Cascade in Male Fertility in Anopheles gambiae. PLoS Biol (2015) 1.41
An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. PLoS Pathog (2015) 1.38
Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes. BMC Microbiol (2009) 1.36
Close kinship within multiple-genotype malaria parasite infections. Proc Biol Sci (2012) 1.35
The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae. PLoS Biol (2010) 1.34
Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum. PLoS Pathog (2010) 1.34
SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system. BMC Genomics (2008) 1.28
Transmission blocking immunity in the malaria non-vector mosquito Anopheles quadriannulatus species A. PLoS Pathog (2008) 1.26
Ecological immunology of mosquito-malaria interactions. Trends Parasitol (2008) 1.26
Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae. PLoS Biol (2011) 1.25
Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection. BMC Genomics (2009) 1.24
Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes. Cell Mol Life Sci (2010) 1.23
Genetic mapping of specific interactions between Aedes aegypti mosquitoes and dengue viruses. PLoS Genet (2013) 1.20
Structure-function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1. PLoS Pathog (2011) 1.18
A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc Natl Acad Sci U S A (2010) 1.17
Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins. BMC Genomics (2010) 1.16
Transgenic technologies to induce sterility. Malar J (2009) 1.16
Nature, nurture and evolution of intra-species variation in mosquito arbovirus transmission competence. Int J Environ Res Public Health (2013) 1.15
The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evol Biol (2008) 1.15
Density-dependent impact of the human malaria parasite Plasmodium falciparum gametocyte sex ratio on mosquito infection rates. Proc Biol Sci (2009) 1.15
Evidence for a population expansion in the West Nile virus vector Culex tarsalis. Mol Biol Evol (2007) 1.11
The mosquito melanization response is implicated in defense against the entomopathogenic fungus Beauveria bassiana. PLoS Pathog (2012) 1.11
Patterns of selection in anti-malarial immune genes in malaria vectors: evidence for adaptive evolution in LRIM1 in Anopheles arabiensis. PLoS One (2007) 1.04
Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity. PLoS Pathog (2011) 1.04
The CLIP-domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae. PLoS Pathog (2013) 1.02
Hydric stress-dependent effects of Plasmodium falciparum infection on the survival of wild-caught Anopheles gambiae female mosquitoes. Malar J (2010) 1.02
Molecular evolution of immune genes in the malaria mosquito Anopheles gambiae. PLoS One (2009) 1.01
Challenges and approaches for mosquito targeted malaria control. Curr Mol Med (2009) 1.01
Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proc Natl Acad Sci U S A (2014) 1.00
A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae. Malar J (2007) 1.00
The Anopheles innate immune system in the defense against malaria infection. J Innate Immun (2013) 0.98
Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection. Malar J (2010) 0.97
Low linkage disequilibrium in wild Anopheles gambiae s.l. populations. BMC Genet (2010) 0.96
Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites. BMC Genomics (2014) 0.95
Cytogenetic map for Anopheles nili: application for population genetics and comparative physical mapping. Infect Genet Evol (2010) 0.95
Mosquito transcriptome changes and filarial worm resistance in Armigeres subalbatus. BMC Genomics (2007) 0.94
Genetic variation affecting host-parasite interactions: different genes affect different aspects of sigma virus replication and transmission in Drosophila melanogaster. Genetics (2008) 0.94
Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling. Trends Parasitol (2008) 0.94
Development of the bi-partite Gal4-UAS system in the African malaria mosquito, Anopheles gambiae. PLoS One (2012) 0.94
The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases. BMC Genomics (2011) 0.94
Chlamydomonas reinhardtii as a viable platform for the production of recombinant proteins: current status and perspectives. Plant Cell Rep (2011) 0.93
Semele: a killer-male, rescue-female system for suppression and replacement of insect disease vector populations. Genetics (2010) 0.92
Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology. Curr Opin Microbiol (2012) 0.92
An overview of malaria transmission from the perspective of Amazon Anopheles vectors. Mem Inst Oswaldo Cruz (2015) 0.92
Equivalent susceptibility of Anopheles gambiae M and S molecular forms and Anopheles arabiensis to Plasmodium falciparum infection in Burkina Faso. Malar J (2013) 0.92
Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali. Malar J (2012) 0.91
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae. Proc Natl Acad Sci U S A (2013) 0.91
Using comparative genomic hybridization to survey genomic sequence divergence across species: a proof-of-concept from Drosophila. BMC Genomics (2010) 0.90
Susceptibility of Anopheles gambiae and Anopheles stephensi to tropical isolates of Plasmodium falciparum. Malar J (2007) 0.90
Single-nucleotide polymorphisms for high-throughput genotyping of Anopheles arabiensis in East and southern Africa. J Med Entomol (2012) 0.89
Modulation of malaria infection in Anopheles gambiae mosquitoes exposed to natural midgut bacteria. PLoS One (2013) 0.89
Parasite killing in malaria non-vector mosquito Anopheles culicifacies species B: implication of nitric oxide synthase upregulation. PLoS One (2011) 0.89
A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog (2015) 0.88
Anopheles immune genes and amino acid sites evolving under the effect of positive selection. PLoS One (2010) 0.88
Adaptation through chromosomal inversions in Anopheles. Front Genet (2014) 0.88
Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens. PLoS Pathog (2014) 0.88
Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae. PLoS One (2013) 0.88
Evaluation and optimization of membrane feeding compared to direct feeding as an assay for infectivity. Malar J (2008) 0.87
Generation, annotation, and analysis of ESTs from midgut tissue of adult female Anopheles stephensi mosquitoes. BMC Genomics (2009) 0.87
Malarial fever: hemozoin is involved but Toll-free. Proc Natl Acad Sci U S A (2007) 0.86
A new factor in the Aedes aegypti immune response: CLSP2 modulates melanization. EMBO Rep (2011) 0.86
A critical assessment of cross-species detection of gene duplicates using comparative genomic hybridization. BMC Genomics (2010) 0.86
Three genes involved in the oxidative burst are closely linked in the genome of the snail, Biomphalaria glabrata. Int J Parasitol (2012) 0.86
The biological control of the malaria vector. Toxins (Basel) (2012) 0.86
Comparison of male reproductive success in malaria-refractory and susceptible strains of Anopheles gambiae. Malar J (2008) 0.85
Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites. PLoS Genet (2015) 0.85
Anopheles gambiae PRS1 modulates Plasmodium development at both midgut and salivary gland steps. PLoS One (2010) 0.85
Evidence for population-specific positive selection on immune genes of Anopheles gambiae. G3 (Bethesda) (2012) 0.84
Phylogeny of anopheline (Diptera: Culicidae) species in southern Africa, based on nuclear and mitochondrial genes. J Vector Ecol (2015) 0.84
Genome-wide patterns of polymorphism in an inbred line of the African malaria mosquito Anopheles gambiae. Genome Biol Evol (2014) 0.84
The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing. Malar J (2015) 0.83
Allelic gene structure variations in Anopheles gambiae mosquitoes. PLoS One (2010) 0.82
Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system. BMC Genomics (2007) 0.81
A compendium of molecules involved in vector-pathogen interactions pertaining to malaria. Malar J (2013) 0.81
An impossible journey? The development of Plasmodium falciparum NF54 in Culex quinquefasciatus. PLoS One (2013) 0.80
MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota. Dev Comp Immunol (2014) 0.80
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae. J Biol Chem (2013) 0.80
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Genetic dissection of transcriptional regulation in budding yeast. Science (2002) 25.01
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet (2003) 11.84
The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A (2005) 9.66
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Mapping complex disease loci in whole-genome association studies. Nature (2004) 7.31
Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol (2004) 7.11
Patterns of linkage disequilibrium in the human genome. Nat Rev Genet (2002) 7.09
Echinococcosis. Lancet (2003) 6.83
Genetics of global gene expression. Nat Rev Genet (2006) 6.80
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Genetic interactions between polymorphisms that affect gene expression in yeast. Nature (2005) 6.42
Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics (2009) 6.41
Genetic structure of the purebred domestic dog. Science (2004) 6.39
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol (2005) 5.61
Immunity-related genes and gene families in Anopheles gambiae. Science (2002) 5.47
Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet (2003) 5.30
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Gene-environment interaction in yeast gene expression. PLoS Biol (2008) 4.48
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood (2010) 4.33
Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature (2010) 4.32
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet (2008) 4.02
[Human natural infection of Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2006) 3.99
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature (2009) 3.67
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63
Finding the sources of missing heritability in a yeast cross. Nature (2013) 3.43
The role of geography in human adaptation. PLoS Genet (2009) 3.41
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med (2008) 3.33
Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science (2006) 3.32
Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet (2005) 3.23
Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet (2009) 3.14
Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol (2012) 3.08
Genetic basis of proteome variation in yeast. Nat Genet (2007) 3.04
Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs. Hepatology (2012) 3.04
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature (2004) 3.00
Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res (2004) 2.85
Genome-wide measurement of RNA folding energies. Mol Cell (2012) 2.85
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet (2012) 2.85
Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science (2008) 2.84
Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science (2010) 2.84
A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites. Science (2011) 2.81
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol (2007) 2.77
Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev (2003) 2.77
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76
Using whole-exome sequencing to identify inherited causes of autism. Neuron (2013) 2.74
Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet (2008) 2.71
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Brain anatomical network and intelligence. PLoS Comput Biol (2009) 2.68
Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res (2005) 2.66
Dynamic gut microbiome across life history of the malaria mosquito Anopheles gambiae in Kenya. PLoS One (2011) 2.64
Surveillance of demographic characteristics and health behaviors among adult cancer survivors--Behavioral Risk Factor Surveillance System, United States, 2009. MMWR Surveill Summ (2012) 2.57
Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali. Trop Med Int Health (2005) 2.57
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol Psychiatry (2004) 2.53
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
Population genomic analysis of outcrossing and recombination in yeast. Nat Genet (2006) 2.50
Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology (2004) 2.48
Risk factors for malaria infection and anemia for pregnant women in the Sahel area of Bandiagara, Mali. Acta Trop (2003) 2.47
Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron (2009) 2.44
False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene. Am J Trop Med Hyg (2012) 2.43
Basis set exchange: a community database for computational sciences. J Chem Inf Model (2007) 2.37
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet (2006) 2.36
Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. Arthritis Rheum (2011) 2.33
Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature (2011) 2.32
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest (2014) 2.31
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Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22
Space-time clustering of childhood malaria at the household level: a dynamic cohort in a Mali village. BMC Public Health (2006) 2.20
The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg (2002) 2.20
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun (2005) 2.18
Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet (2007) 2.18
A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 2.17
Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol (2013) 2.16