Published in J Invest Dermatol on December 30, 2010
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
Neural processing of itch. Neuroscience (2013) 1.32
BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci (2011) 1.29
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses. Gene (2013) 0.98
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons. Neuroscience (2012) 0.85
The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol (2014) 0.82
Neuroendocrinology of the skin: An overview and selective analysis. Dermatoendocrinol (2011) 0.81
Comparison of stimulating effect on subpopulations of lymphocytes in human peripheral blood by methionine enkephalin with IL-2 and IFN-γ. Hum Vaccin Immunother (2012) 0.80
Roles of Gr-1+ leukocytes in postincisional nociceptive sensitization and inflammation. Anesthesiology (2012) 0.80
High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD. J Am Soc Nephrol (2016) 0.79
On the role of the endogenous opioid system in regulating epidermal homeostasis. J Invest Dermatol (2015) 0.77
Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. Front Cell Neurosci (2015) 0.77
Neuro-immune-endocrine functions of the skin: an overview. Expert Rev Dermatol (2013) 0.76
Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case-Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors. Am J Dermatopathol (2016) 0.75
Primary afferent neurons express functional delta opioid receptors in inflamed skin. Brain Res (2015) 0.75
Does melanin matter in the dark? Exp Dermatol (2016) 0.75
Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. J Invest Dermatol (2013) 0.75
Melatonin, mitochondria, and the skin. Cell Mol Life Sci (2017) 0.75
Characterisation of the cancer-associated glucocorticoid system: key role of 11β-hydroxysteroid dehydrogenase type 2. Br J Cancer (2017) 0.75
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
Neuroendocrinology of the skin. Endocr Rev (2000) 3.34
Stratum corneum defensive functions: an integrated view. J Invest Dermatol (2005) 3.20
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46
A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev (1989) 2.12
The skin barrier as an innate immune element. Semin Immunopathol (2007) 1.81
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J (2005) 1.77
Neuroimmunology of stress: skin takes center stage. J Invest Dermatol (2006) 1.72
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc Natl Acad Sci U S A (1999) 1.68
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med (1993) 1.58
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
Ultraviolet exposure is a reinforcing stimulus in frequent indoor tanners. J Am Acad Dermatol (2004) 1.35
Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab (2007) 1.20
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Biochemistry of human skin--our brain on the outside. Chem Soc Rev (2005) 1.16
The N- and C-terminal fragments of ubiquitin are important for the antimicrobial activities. FASEB J (2003) 1.14
Primary structure of the human proenkephalin gene. DNA (1983) 1.14
Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia (1992) 1.05
Mu-opiate receptor and Beta-endorphin expression in nerve endings and keratinocytes in human skin. Dermatology (2004) 1.04
The skin produces urocortin. J Clin Endocrinol Metab (2000) 1.01
Catecholamines in human keratinocyte differentiation. J Invest Dermatol (1995) 0.98
Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J Clin Endocrinol Metab (2000) 0.96
The keratinocyte as a target for staphylococcal bacterial toxins. J Investig Dermatol Symp Proc (2001) 0.96
Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin. J Histochem Cytochem (2000) 0.93
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. Mol Ther (2004) 0.93
beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol (2004) 0.93
Innate immunity: involvement of new neuropeptides. Trends Microbiol (2003) 0.92
T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells. J Neuroimmunol (1997) 0.92
Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids. Importance of enkelytin, the antibacterial PEAP209-237 secreted by stimulated chromaffin cells. J Biol Chem (1998) 0.91
Expression of mu-opiate receptor in human epidermis and keratinocytes. J Invest Dermatol (1998) 0.90
Characterization of opioid peptides in guinea-pig heart and skin. Life Sci (1983) 0.89
Proenkephalin A-derived peptides in invertebrate innate immune processes. Brain Res Mol Brain Res (2000) 0.89
Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis. Nature (1984) 0.89
Production of bioactive peptides in an in vitro system. Anal Biochem (2007) 0.88
beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis. J Invest Dermatol (2000) 0.86
Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression. J Invest Dermatol (2003) 0.86
Processing of proenkephalin-A in bovine chromaffin cells. Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Biol Chem (2000) 0.86
Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study. J Neurochem (2003) 0.85
Pain, immunity, opiate and opioid compounds and health. Med Sci Monit (2005) 0.85
Characterization of mu-opiate receptor in human epidermis and keratinocytes. Ann N Y Acad Sci (1999) 0.85
Developmental regulation of proenkephalin gene expression in osteoblasts. Mol Endocrinol (1995) 0.84
Identification of beta-endorphin, alpha-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC. Exp Dermatol (1998) 0.83
Antimicrobial chromogranins and proenkephalin-A-derived peptides: Antibacterial and antifungal activities of chromogranins and proenkephalin-A-derived peptides. Ann N Y Acad Sci (2003) 0.83
The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery. J Neuroimmunol (2000) 0.82
Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues. Mol Cell Biol (1990) 0.82
Increased levels of enkephalin following natural sunlight (combined with salt water bathing at the Dead Sea) and ultraviolet A irradiation. Br J Dermatol (1998) 0.81
Immunocytochemical evidence of a met-enkephalin-like substance in the dense-core granules of mouse Merkel cells. Cell Tissue Res (1991) 0.81
Widespread organ expression of the rat proenkephalin gene during early postnatal development. Mol Endocrinol (1990) 0.81
Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production. J Neuroimmunol (1998) 0.80
The opioid growth factor, [Met5]-enkephalin, and the zeta opioid receptor are present in human and mouse skin and tonically act to inhibit DNA synthesis in the epidermis. J Invest Dermatol (1996) 0.79
Enkephalins modulate differentiation of normal human keratinocytes in vitro. Exp Dermatol (1997) 0.78
Regulation of proenkephalin expression in cultured skin mesenchymal cells. Mol Endocrinol (1992) 0.78
Regulation of proenkephalin A messenger ribonucleic acid levels in normal B lymphocytes: specific inhibition by glucocorticoid hormones and superinduction by cycloheximide. Endocrinology (1991) 0.77
Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes. J Clin Invest (1991) 0.77
Antibacterial and antifungal peptides derived from chromogranins and proenkephalin-A. From structural to biological aspects. Adv Exp Med Biol (2000) 0.77
Identification and measurement of beta-endorphin levels in the skin during induced hair growth in mice. Biochim Biophys Acta (1997) 0.77
Decrease in enkephalin levels in psoriatic lesions after calcipotriol and mometasone furoate treatment. Dermatology (1999) 0.77
Lipopolysaccharide induces proenkephalin gene expression in rat lymph nodes and adrenal glands. Endocrinology (1994) 0.77
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res (2011) 2.07
In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1. FASEB J (2012) 1.92
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol (2008) 1.91
Hair follicle pigmentation. J Invest Dermatol (2005) 1.84
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J (2008) 1.84
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS One (2010) 1.83
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J (2005) 1.77
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71
Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells. Int J Cancer (2009) 1.70
Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol (2007) 1.67
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. PLoS One (2009) 1.65
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoS One (2009) 1.52
Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology (2003) 1.46
Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background. Endocrinology (2004) 1.45
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
On the role of melatonin in skin physiology and pathology. Endocrine (2005) 1.43
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol (2005) 1.42
Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol (2006) 1.41
Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol (2003) 1.41
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A (2002) 1.37
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. Chem Biol (2005) 1.36
Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J (2002) 1.33
Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem (2002) 1.26
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. FASEB J (2009) 1.22
Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem (2014) 1.20
Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab (2007) 1.20
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Ancient mitochondrial DNA from hair. Curr Biol (2004) 1.19
Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2008) 1.17
Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab (2008) 1.15
Serotoninergic system in hamster skin. J Invest Dermatol (2002) 1.12
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Res (2013) 1.12
Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J (2007) 1.12
Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB. Pigment Cell Res (2006) 1.10
Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin. J Invest Dermatol (2002) 1.09
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol (2011) 1.07
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett (2002) 1.05
Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging. Micron (2004) 1.04
Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin. Brain Behav Immun (2005) 1.04
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells (2011) 1.03
The role of melanin pigment in melanoma. Exp Dermatol (2015) 1.03
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol (2008) 1.03
Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol (2006) 1.00
Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo. Dermatology (2002) 1.00
Opioids and the skin--where do we stand? Exp Dermatol (2009) 0.99
The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci (2005) 0.98
Tryptophan hydroxylase expression in human skin cells. Biochim Biophys Acta (2003) 0.98
Melanin transfer in human skin cells is mediated by filopodia--a model for homotypic and heterotypic lysosome-related organelle transfer. FASEB J (2010) 0.98
Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem (2010) 0.98
Characterization of the serotoninergic system in the C57BL/6 mouse skin. Eur J Biochem (2003) 0.97
Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer Res (2007) 0.97
Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J Invest Dermatol (2002) 0.95
New vitamin D analogs as potential therapeutics in melanoma. Expert Rev Anticancer Ther (2012) 0.94
CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes. J Invest Dermatol (2006) 0.94
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J (2006) 0.94
Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes. J Nanosci Nanotechnol (2011) 0.93
beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol (2004) 0.93
Melatonin and the hair follicle. J Pineal Res (2008) 0.93
Resistance of degraded hair shafts to contaminant DNA. Forensic Sci Int (2005) 0.92
Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol (2007) 0.92
Mutant laboratory mice with abnormalities in pigmentation: annotated tables. J Dermatol Sci (2002) 0.91
Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles. Exp Dermatol (2002) 0.91
Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J (2006) 0.90
Matrix metalloproteinase-9 is involved in the regulation of hair canal formation. J Invest Dermatol (2010) 0.88
Bone morphogenetic proteins differentially regulate pigmentation in human skin cells. J Cell Sci (2012) 0.88
A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis. PeerJ (2013) 0.88
Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem (2007) 0.87
The analysis of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) immunoreactivity within the microenvironment of the ovarian cancer lesion relative to the applied therapeutic strategy. Cell Tissue Res (2011) 0.87
The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte-keratinocyte co-culture. Exp Dermatol (2008) 0.87
Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp Dermatol (2003) 0.87
Changes in different melanocyte populations during hair follicle involution (catagen). J Invest Dermatol (2005) 0.86
Human hair follicle and epidermal melanocytes exhibit striking differences in their aging profile which involves catalase. J Invest Dermatol (2010) 0.86
Modelling the buried human body environment in upland climes using three contrasting field sites. Forensic Sci Int (2006) 0.86
Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. J Invest Dermatol (2008) 0.85