Published in Drug Discov Today Dis Mech on June 01, 2008
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1. FASEB J (2012) 1.92
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS One (2010) 1.83
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71
Current concepts of metastasis in melanoma. Expert Rev Dermatol (2008) 1.34
Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem (2014) 1.20
Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol (2010) 1.17
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. Int J Biochem Cell Biol (2012) 1.14
Neuroendocrine activity of the melanocyte. Exp Dermatol (2009) 1.12
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol (2010) 0.97
Novel vitamin D photoproducts and their precursors in the skin. Dermatoendocrinol (2013) 0.96
Stress-linked cortisol concentrations in hair: what we know and what we need to know. Rev Neurosci (2011) 0.90
Melanin: the biophysiology of oral melanocytes and physiological oral pigmentation. Head Face Med (2014) 0.88
"Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands. Pflugers Arch (2011) 0.87
Glucocorticoid receptors, epidermal homeostasis and hair follicle differentiation. Dermatoendocrinol (2011) 0.87
Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing. PLoS One (2012) 0.83
Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation. Exp Dermatol (2012) 0.82
Neuroendocrinology of the skin: An overview and selective analysis. Dermatoendocrinol (2011) 0.81
Norepinephrine and adenosine-5'-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Cytokine (2013) 0.80
Nicotinic receptor signaling in nonexcitable epithelial cells: paradigm shifting from ion current to kinase cascade. Focus on "Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases". Am J Physiol Cell Physiol (2010) 0.79
11β-hydroxysteroid dehydrogenase 1 specific inhibitor increased dermal collagen content and promotes fibroblast proliferation. PLoS One (2014) 0.79
Stressing the steroids in skin: paradox or fine-tuning? J Invest Dermatol (2014) 0.77
Transcriptome analysis of skin photoaging in chinese females reveals the involvement of skin homeostasis and metabolic changes. PLoS One (2013) 0.77
Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice. PLoS One (2016) 0.75
Effects of GUASHA on Heart Rate Variability in Healthy Male Volunteers under Normal Condition and Weightlifters after Weightlifting Training Sessions. Evid Based Complement Alternat Med (2015) 0.75
Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans. Res Pharm Sci (2016) 0.75
Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. J Invest Dermatol (2013) 0.75
Melatonin, mitochondria, and the skin. Cell Mol Life Sci (2017) 0.75
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Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol (2001) 2.34
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23
Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol (2006) 2.17
A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci U S A (2003) 2.13
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol (2003) 2.10
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An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J (2001) 1.74
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
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CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J (2001) 1.59
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Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci (2004) 1.50
Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol (2001) 1.48
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. J Invest Dermatol (2003) 1.47
Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology (2003) 1.46
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol (2005) 1.42
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CRH functions as a growth factor/cytokine in the skin. J Cell Physiol (2006) 1.38
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. Chem Biol (2005) 1.36
Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. J Invest Dermatol (2005) 1.26
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Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem (2004) 1.22
Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A (2002) 1.22
Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. Am J Physiol Regul Integr Comp Physiol (2006) 1.19
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The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol (2006) 1.01
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The role of psychological stress in skin disease. J Cutan Med Surg (2001) 0.99
Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J Invest Dermatol (2002) 0.95
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Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin. J Histochem Cytochem (2000) 0.93
Production of POMC, CRH-R1, MC1, and MC2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin. J Invest Dermatol (1997) 0.93
Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J (2006) 0.90
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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res (2004) 4.67
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet (2007) 3.94
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem (2003) 3.19
Thiazolidinedione use and bone loss in older diabetic adults. J Clin Endocrinol Metab (2006) 3.15
Molecular principles of hair follicle induction and morphogenesis. Bioessays (2005) 3.08
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
Alopecia areata. N Engl J Med (2012) 2.56
Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Arterioscler Thromb Vasc Biol (2005) 2.56
The hair follicle as a dynamic miniorgan. Curr Biol (2009) 2.52
Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization. J Invest Dermatol (2010) 2.48
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
Diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care (2007) 2.39
Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. Cell Host Microbe (2010) 2.39
IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev (2006) 2.29
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science (2010) 2.21
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol (2007) 2.02
IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med (2007) 2.00
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol (2002) 1.94
Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet (2007) 1.87
Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol (2007) 1.85
Hair follicle pigmentation. J Invest Dermatol (2005) 1.84
The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol (2008) 1.79
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J (2005) 1.77
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol (2003) 1.75
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem (2003) 1.72
Retracted A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J (2005) 1.72
Neuroimmunology of stress: skin takes center stage. J Invest Dermatol (2006) 1.72
The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays (2006) 1.70
FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol (2006) 1.70
Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. J Lipid Res (2008) 1.69
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69
Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol (2007) 1.67
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Metabolism (2007) 1.60
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest (2002) 1.58
Neuronal plasticity of the "brain-skin connection": stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways. J Mol Med (Berl) (2007) 1.58
Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest (2007) 1.56
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol (2009) 1.52
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol (2005) 1.51
Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol (2006) 1.51
Mast cells are required for normal healing of skin wounds in mice. FASEB J (2006) 1.50
Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet (2009) 1.49
GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. J Invest Dermatol (2012) 1.48
Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. J Invest Dermatol (2003) 1.47
Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology (2003) 1.46
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol (2004) 1.45
Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background. Endocrinology (2004) 1.45
On the role of melatonin in skin physiology and pathology. Endocrine (2005) 1.43
Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation. J Invest Dermatol (2011) 1.43
Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol (2008) 1.43
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol (2005) 1.42
Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol (2006) 1.41
Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. J Invest Dermatol (2007) 1.41
Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol (2003) 1.41
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol (2011) 1.41
Ultrasound in-depth characterization and staging of hidradenitis suppurativa. Dermatol Surg (2013) 1.40
Pentosidine and increased fracture risk in older adults with type 2 diabetes. J Clin Endocrinol Metab (2009) 1.38
NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem (2002) 1.38
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A (2002) 1.37
Molecular biology of hair morphogenesis: development and cycling. J Exp Zool B Mol Dev Evol (2003) 1.36