Published in Endocrinology on November 06, 2003
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Front Neuroendocrinol (2006) 1.60
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care (New Rochelle) (2014) 1.45
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
On the role of melatonin in skin physiology and pathology. Endocrine (2005) 1.43
CRH functions as a growth factor/cytokine in the skin. J Cell Physiol (2006) 1.38
Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem (2011) 1.36
Neuroendocrine system of the skin. Dermatology (2005) 1.24
Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem (2004) 1.22
UVB Activates Hypothalamic-Pituitary-Adrenal Axis in C57BL/6 Mice. J Invest Dermatol (2014) 1.20
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol (2006) 1.16
Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J (2007) 1.12
Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proc Natl Acad Sci U S A (2006) 1.10
Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J Invest Dermatol (2011) 1.03
On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol (2009) 1.02
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations. J Cell Physiol (2009) 1.00
Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium. J Endocrinol (2007) 0.98
Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses. Gene (2013) 0.98
Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol (2010) 0.97
CRH inhibits NF-kappa B signaling in human melanocytes. Peptides (2006) 0.96
Brain-skin connection: stress, inflammation and skin aging. Inflamm Allergy Drug Targets (2014) 0.95
Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J (2006) 0.90
Stress-linked cortisol concentrations in hair: what we know and what we need to know. Rev Neurosci (2011) 0.90
Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol (2005) 0.90
"Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands. Pflugers Arch (2011) 0.87
Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis. Dermatol Res Pract (2012) 0.85
The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris. Dermatoendocrinol (2009) 0.84
Treatment with CRH-1 antagonist antalarmin reduces behavioral and endocrine responses to social stressors in marmosets (Callithrix kuhlii). Am J Primatol (2007) 0.84
CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLoS One (2011) 0.82
Neurotensin and CRH interactions augment human mast cell activation. PLoS One (2012) 0.82
Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20--emerging role of soluble isoforms. J Physiol Pharmacol (2009) 0.81
Hormones and the pilosebaceous unit. Dermatoendocrinol (2009) 0.81
Neuroendocrinology of the skin: An overview and selective analysis. Dermatoendocrinol (2011) 0.81
Chronic stress suppresses the expression of cutaneous hypothalamic-pituitary-adrenocortical axis elements and melanogenesis. PLoS One (2014) 0.80
Breast and infant temperatures with twins during shared Kangaroo Care. J Obstet Gynecol Neonatal Nurs (2006) 0.78
Commentary on the practical guide for the study of sebaceous glands. Exp Dermatol (2013) 0.78
Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism. Transl Psychiatry (2014) 0.78
Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts. Dermatoendocrinol (2009) 0.76
New approach to the understanding of keloid: psychoneuroimmune-endocrine aspects. Clin Cosmet Investig Dermatol (2015) 0.76
High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma. Oncotarget (2015) 0.75
Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes. Mol Cell Endocrinol (2016) 0.75
Protective role of the neuropeptide urocortin II against experimental sepsis and leishmaniasis by direct killing of pathogens. J Immunol (2013) 0.75
Inhibiting interleukin-18 production through the mitogen-activated protein kinase pathway, a potential role of corticotropin-releasing hormone in chronic plaque psoriasis. Inflammation (2015) 0.75
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron (1998) 3.08
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A (2001) 2.87
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med (2001) 2.33
Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci (1999) 2.04
The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci (2002) 1.84
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J (2001) 1.74
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J (2001) 1.59
Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature (1991) 1.51
Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol Metab (2002) 1.46
Corticotrophin-releasing factor receptors: from molecular biology to drug design. Trends Pharmacol Sci (1996) 1.40
Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa. J Cell Sci (1988) 1.30
Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol (1994) 1.27
Factors regulating growth and pigmentation of melanoma cells. J Invest Dermatol (1976) 1.23
Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A (2002) 1.22
A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. Mol Endocrinol (1999) 1.21
Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. Endocrinology (2003) 1.19
Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci (1999) 1.18
Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor. Mol Endocrinol (1998) 1.17
Corticotropin releasing hormone, receptor regulation and the stress response. Trends Endocrinol Metab (1998) 1.11
Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals. J Endocrinol (2002) 1.09
Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim (2001) 1.07
Characterization of corticotropin-releasing hormone (CRH) in human skin. J Clin Endocrinol Metab (1998) 1.06
Corticotropin releasing hormone and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Dev Biol Anim (2000) 1.04
Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett (1995) 1.02
Different populations of melanocytes are present in hair follicles and epidermis. Pigment Cell Res (1996) 1.01
The skin produces urocortin. J Clin Endocrinol Metab (2000) 1.01
Modification of melanogenesis in cultured human melanoma cells. In Vitro Cell Dev Biol Anim (2000) 1.00
Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. FASEB J (1998) 0.99
In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J (2001) 0.98
Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J Clin Endocrinol Metab (2000) 0.96
Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology (1996) 0.96
The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. Biochim Biophys Acta (1996) 0.96
Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol (2002) 0.95
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology (2001) 0.94
Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: identification of multiple splice variants. Mol Endocrinol (2002) 0.93
PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum. In Vitro Cell Dev Biol Anim (2000) 0.93
Corticotrophin releasing hormone: its potential for a role in human myometrium. Exp Physiol (2001) 0.91
A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. Biochim Biophys Acta (1997) 0.89
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis. J Cell Sci (1989) 0.88
The genomic organization of the human corticotropin-releasing factor type-1 receptor. Gene (1998) 0.87
Relaxing actions of corticotropin-releasing factor on rat resistance arteries. Br J Pharmacol (1993) 0.87
Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro. J Neuroendocrinol (1996) 0.86
Colour genes, oncogenes and melanocyte differentiation. J Cell Sci (1991) 0.85
Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium. Eur J Pharmacol (1987) 0.85
Identification of beta-endorphin, alpha-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC. Exp Dermatol (1998) 0.83
Expression of corticotrophin-releasing hormone receptor mRNA and protein in the human myometrium. J Endocrinol (1998) 0.82
Cutaneous metabolism of vitamin B-6. J Invest Dermatol (2003) 0.80
Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with elevated tyrosinase activity. J Invest Dermatol (1987) 0.80
Studies of the role of endothelium-dependent nitric oxide release in the sustained vasodilator effects of corticotrophin releasing factor and sauvagine. Br J Pharmacol (1999) 0.78
Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem (2004) 2.42
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem (2005) 1.88
Hair follicle pigmentation. J Invest Dermatol (2005) 1.84
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J (2005) 1.77
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Similarities and differences in the innervation of mystacial vibrissal follicle-sinus complexes in the rat and cat: a confocal microscopic study. J Comp Neurol (2002) 1.68
Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol (2007) 1.67
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab (2004) 1.64
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med (2003) 1.54
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background. Endocrinology (2004) 1.45
On the role of melatonin in skin physiology and pathology. Endocrine (2005) 1.43
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol (2005) 1.42
Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol (2006) 1.41
Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol (2003) 1.41
Ultrasound in-depth characterization and staging of hidradenitis suppurativa. Dermatol Surg (2013) 1.40
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A (2002) 1.37
Glucan-binding proteins are essential for shaping Streptococcus mutans biofilm architecture. FEMS Microbiol Lett (2006) 1.36
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. Chem Biol (2005) 1.36
Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J Biol Chem (2005) 1.33
Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J (2002) 1.33
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nat Neurosci (2010) 1.30
Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB J (2006) 1.29
Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem (2002) 1.26
Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells. J Gen Physiol (2005) 1.25
TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. Cancer Res (2009) 1.24
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. FASEB J (2009) 1.22
Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer. J Biol Chem (2006) 1.22
Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem (2014) 1.20
Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab (2007) 1.20
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Ancient mitochondrial DNA from hair. Curr Biol (2004) 1.19
Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol (2010) 1.17
Genetic requirement for pneumococcal ear infection. PLoS One (2007) 1.16
Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol (2006) 1.16
Friedreich ataxia: neuropathology revised. J Neuropathol Exp Neurol (2013) 1.15
Serotoninergic system in hamster skin. J Invest Dermatol (2002) 1.12
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Res (2013) 1.12
Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J (2007) 1.12
Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB. Pigment Cell Res (2006) 1.10
Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells. Biochemistry (2004) 1.09
Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin. J Invest Dermatol (2002) 1.09
Ultrasound accuracy in the diagnosis of skin and soft-tissue lesions. AJR Am J Roentgenol (2015) 1.09
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol (2011) 1.07
Clinical usefulness of variable-frequency ultrasound in localized lesions of the skin. J Am Acad Dermatol (2009) 1.05
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett (2002) 1.05
Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging. Micron (2004) 1.04
Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin. Brain Behav Immun (2005) 1.04
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells (2011) 1.03
Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res (2009) 1.03
Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing. Endocrinology (2007) 1.02
Friedreich's ataxia causes redistribution of iron, copper, and zinc in the dentate nucleus. Cerebellum (2012) 1.00
Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol (2006) 1.00
Fluorescence correlation spectroscopy analysis of serotonin, adrenergic, muscarinic, and dopamine receptor dimerization: the oligomer number puzzle. Mol Pharmacol (2013) 1.00
Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo. Dermatology (2002) 1.00
Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci (2002) 0.99
Opioids and the skin--where do we stand? Exp Dermatol (2009) 0.99
Benign tumors and pseudotumors of the nail: a novel application of sonography. J Ultrasound Med (2010) 0.99
The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci (2005) 0.98
Tryptophan hydroxylase expression in human skin cells. Biochim Biophys Acta (2003) 0.98
Melanin transfer in human skin cells is mediated by filopodia--a model for homotypic and heterotypic lysosome-related organelle transfer. FASEB J (2010) 0.98
Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem (2010) 0.98
Characterization of the serotoninergic system in the C57BL/6 mouse skin. Eur J Biochem (2003) 0.97
Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J Invest Dermatol (2002) 0.95
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J (2006) 0.94
Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes. J Nanosci Nanotechnol (2011) 0.93
beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol (2004) 0.93
Melatonin and the hair follicle. J Pineal Res (2008) 0.93
Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol (2007) 0.92
Resistance of degraded hair shafts to contaminant DNA. Forensic Sci Int (2005) 0.92
The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization. Endocrinology (2011) 0.92
Mutant laboratory mice with abnormalities in pigmentation: annotated tables. J Dermatol Sci (2002) 0.91
Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles. Exp Dermatol (2002) 0.91