PubRank

Gad Getz

Author PubWeight™ 747.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MicroRNA expression profiles classify human cancers. Nature 2005 69.12
2 Integrative genomics viewer. Nat Biotechnol 2011 42.83
3 Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010 39.09
4 The landscape of somatic copy-number alteration across human cancers. Nature 2010 31.88
5 The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012 31.78
6 Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008 30.02
7 International network of cancer genome projects. Nature 2010 20.35
8 Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 2013 20.16
9 Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013 19.87
10 Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A 2007 18.83
11 Initial genome sequencing and analysis of multiple myeloma. Nature 2011 17.28
12 BRAF mutation predicts sensitivity to MEK inhibition. Nature 2005 17.14
13 The mutational landscape of head and neck squamous cell carcinoma. Science 2011 16.88
14 Characterizing the cancer genome in lung adenocarcinoma. Nature 2007 16.48
15 Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol 2013 16.13
16 Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005 15.28
17 The genomic complexity of primary human prostate cancer. Nature 2011 14.06
18 A landscape of driver mutations in melanoma. Cell 2012 12.61
19 High-resolution mapping of copy-number alterations with massively parallel sequencing. Nat Methods 2008 12.56
20 The somatic genomic landscape of glioblastoma. Cell 2013 11.73
21 Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012 11.69
22 SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011 11.07
23 Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol 2012 10.87
24 Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet 2010 10.15
25 Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet 2012 9.93
26 GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol 2011 9.60
27 Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013 9.24
28 Integrative analysis of the melanoma transcriptome. Genome Res 2010 8.46
29 Outcome signature genes in breast cancer: is there a unique set? Bioinformatics 2004 7.96
30 Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 2012 7.77
31 Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012 7.76
32 Pan-cancer patterns of somatic copy number alteration. Nat Genet 2013 7.73
33 SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009 7.48
34 Punctuated evolution of prostate cancer genomes. Cell 2013 7.23
35 Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A 2012 7.14
36 Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014 6.12
37 Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet 2010 6.10
38 Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res 2008 5.95
39 Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med 2015 5.71
40 Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012 5.28
41 Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012 5.23
42 Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest 2009 5.07
43 The genetic landscape of high-risk neuroblastoma. Nat Genet 2013 4.71
44 An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet 2013 4.69
45 Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med 2006 4.63
46 Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet 2013 4.48
47 Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A 2011 4.15
48 Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep 2013 3.92
49 The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov 2013 3.71
50 Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest 2012 3.64
51 PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nat Biotechnol 2011 3.57
52 Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas. Clin Cancer Res 2009 3.45
53 Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet 2013 3.19
54 Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A 2012 3.06
55 Making sense of cancer genomic data. Genes Dev 2011 3.01
56 Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun 2013 2.94
57 RNA-SeQC: RNA-seq metrics for quality control and process optimization. Bioinformatics 2012 2.94
58 ContEst: estimating cross-contamination of human samples in next-generation sequencing data. Bioinformatics 2011 2.90
59 Comparative gene marker selection suite. Bioinformatics 2006 2.71
60 Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov 2014 2.64
61 High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nat Biotechnol 2011 2.63
62 MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Cancer Discov 2013 2.61
63 High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer 2008 2.46
64 Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 2007 2.43
65 A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest 2012 2.42
66 Temporal dissection of tumorigenesis in primary cancers. Cancer Discov 2011 2.40
67 KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell 2013 2.34
68 Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 2003 2.15
69 Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med 2014 2.09
70 Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Res 2012 1.82
71 A mathematical framework to determine the temporal sequence of somatic genetic events in cancer. Proc Natl Acad Sci U S A 2010 1.81
72 Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One 2012 1.76
73 Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation. Nucleic Acids Res 2013 1.70
74 Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet 2013 1.56
75 Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell 2012 1.54
76 Oncotator: cancer variant annotation tool. Hum Mutat 2015 1.52
77 Paired-end sequencing of Fosmid libraries by Illumina. Genome Res 2012 1.52
78 Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res 2013 1.51
79 Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nat Biotechnol 2015 1.47
80 Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology 2013 1.41
81 Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients. J Clin Oncol 2013 1.40
82 Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A 2013 1.33
83 Sharing and Specificity of Co-expression Networks across 35 Human Tissues. PLoS Comput Biol 2015 1.27
84 Design principle of gene expression used by human stem cells: implication for pluripotency. FASEB J 2004 1.18
85 Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer. Clin Cancer Res 2013 1.10
86 Finding motifs in promoter regions. J Comput Biol 2005 1.09
87 Cluster analysis of human autoantibody reactivities in health and in type 1 diabetes mellitus: a bio-informatic approach to immune complexity. J Autoimmun 2003 1.08
88 Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer. Oncogene 2005 1.07
89 Computational pathology: an emerging definition. Arch Pathol Lab Med 2014 1.03
90 In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proc Natl Acad Sci U S A 2014 0.99
91 Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. Cell Rep 2016 0.96
92 Nozzle: a report generation toolkit for data analysis pipelines. Bioinformatics 2013 0.92
93 Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun 2014 0.84
94 Characterization of the DNA copy-number genome in the blood of cutaneous T-cell lymphoma patients. J Invest Dermatol 2011 0.81
95 Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer 2014 0.80
96 Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet 2015 0.75
97 High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell 2017 0.75