Published in Am J Pathol on December 23, 2010
Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer's disease. Biomark Med (2012) 1.07
Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J Biol Chem (2012) 0.94
The inverse association of cancer and Alzheimer's: a bioenergetic mechanism. J R Soc Interface (2013) 0.85
The P's and Q's of cellular PrP-Aβ interactions. Prion (2012) 0.83
Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. J Biol Chem (2015) 0.80
Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells. PLoS One (2013) 0.79
Amylin-mediated control of glycemia, energy balance, and cognition. Physiol Behav (2016) 0.78
Lessons from two prevalent amyloidoses-what amylin and Aβ have in common. Front Aging Neurosci (2013) 0.78
Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease. Mol Psychiatry (2016) 0.77
Scutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25-35). Neural Regen Res (2013) 0.77
Amylin receptor: a common pathophysiological target in Alzheimer's disease and diabetes mellitus. Front Aging Neurosci (2013) 0.77
Benzothiazole aniline tetra(ethylene glycol) and 3-amino-1,2,4-triazole inhibit neuroprotection against amyloid peptides by catalase overexpression in vitro. ACS Chem Neurosci (2013) 0.77
Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research. Mol Brain (2014) 0.76
Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease. Chem Sci (2017) 0.75
Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation. J Neuroinflammation (2017) 0.75
Amylin and its G-protein-coupled receptor: a probable pathological process and drug target for Alzheimer's disease. Neuroscience (2017) 0.75
Apoptosis in the nervous system. Nature (2000) 5.82
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem (2001) 4.51
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem (2002) 4.20
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci U S A (1987) 4.19
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci (1992) 4.10
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev (2002) 2.86
Cell death in the nervous system. Nature (2006) 2.62
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene (2004) 2.52
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc Natl Acad Sci U S A (1993) 2.41
Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res (2007) 2.39
Caspases and caspase inhibitors. Trends Biochem Sci (1997) 2.17
Common features between diabetes mellitus and Alzheimer's disease. Cell Mol Life Sci (2009) 1.77
Molecular genetics of Alzheimer's disease: an update. Ann Med (2008) 1.62
Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci (2008) 1.59
Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol (2009) 1.57
Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem (2008) 1.57
Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients. J Virol (1998) 1.52
Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev (2007) 1.44
Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci (2003) 1.43
Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis (2005) 1.39
RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Curr Mol Med (2007) 1.38
Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm (Vienna) (1998) 1.35
Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity. J Neurochem (1993) 1.33
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol Pharmacol (2005) 1.31
Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol (2007) 1.31
Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res (2003) 1.18
Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology (2008) 1.17
Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem (1994) 1.10
Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics (2010) 1.08
The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci (2000) 1.02
Amylin receptors: molecular composition and pharmacology. Biochem Soc Trans (2004) 1.01
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci U S A (2009) 0.96
Galanin attenuates beta-amyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons. Neurobiol Dis (2005) 0.95
Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci (2004) 0.94
Receptor pharmacology. Adv Pharmacol (2005) 0.94
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. J Immunol (2007) 0.93
Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett (2008) 0.93
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry (2007) 0.92
Protective effects of amylin on reserpine-induced gastric damage in the rat. Pharmacol Res (2007) 0.87
Cellular mechanisms for amyloid beta-protein activation of rat cholinergic basal forebrain neurons. J Neurophysiol (2001) 0.87
Links between Alzheimer's disease and diabetes. Drugs Today (Barc) (2006) 0.85
Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants. J Neurochem (2009) 0.85
Nicotinic acetylcholine receptor interaction with beta-amyloid: molecular, cellular, and physiological consequences. Curr Alzheimer Res (2010) 0.85
Human amylin induces "apoptotic" pattern of gene expression concomitant with cortical neuronal apoptosis. J Neurochem (1998) 0.84
Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J Neurophysiol (2003) 0.83
Actions of amylin on subfornical organ neurons and on drinking behavior in rats. Am J Physiol (1999) 0.81
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A (2005) 3.83
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72
Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev (2013) 3.63
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell (2011) 2.77
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
Expression divergence between duplicate genes. Trends Genet (2005) 2.69
Monitoring avian influenza A(H7N9) virus through national influenza-like illness surveillance, China. Emerg Infect Dis (2013) 2.61
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature (2006) 2.56
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res (2011) 2.29
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med (2006) 2.28
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke. Circulation (2002) 2.22
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step. Cell Metab (2005) 2.20
Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr (2012) 2.17
Activation of STAT6 by STING is critical for antiviral innate immunity. Cell (2011) 2.08
Geometric strategies for neuroanatomic analysis from MRI. Neuroimage (2004) 2.07
Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A (2007) 2.04
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02
Crop diversity for yield increase. PLoS One (2009) 2.02
Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther (2003) 1.95
DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol (2010) 1.89
Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic. J Am Chem Soc (2012) 1.86
Th9 cells promote antitumor immune responses in vivo. J Clin Invest (2012) 1.80
Patterns of segmental duplication in the human genome. Mol Biol Evol (2004) 1.76
A novel role for TRPM8 in visceral afferent function. Pain (2011) 1.74
Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res (2007) 1.69
Mer receptor tyrosine kinase signaling participates in platelet function. Arterioscler Thromb Vasc Biol (2004) 1.67
Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci (2010) 1.67
Syndrome differentiation in modern research of traditional Chinese medicine. J Ethnopharmacol (2012) 1.62
Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma. Blood (2009) 1.61
Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small (2008) 1.60
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. Mol Biosyst (2011) 1.58
Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. J Clin Virol (2010) 1.58
Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood (2009) 1.58
A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A (2013) 1.53
NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. J Biol Chem (2002) 1.53
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows. BMC Genomics (2011) 1.52
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Measuring data abstraction quality in multiresolution visualizations. IEEE Trans Vis Comput Graph (2006) 1.51
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J (2007) 1.49
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
The human glomerular podocyte is a novel target for insulin action. Diabetes (2005) 1.49
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus. Blood (2010) 1.47
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol (2009) 1.46
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. PLoS One (2011) 1.46
The expanding universe of prion diseases. PLoS Pathog (2006) 1.45
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes (2003) 1.45
Clinicopathological features of gastric glomus tumor. World J Gastroenterol (2010) 1.44
Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting. FEBS J (2014) 1.43
Structure of Arabidopsis HYPONASTIC LEAVES1 and its molecular implications for miRNA processing. Structure (2010) 1.41
Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. BMC Med Genet (2010) 1.41
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog (2009) 1.41
Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey. Clin Rheumatol (2014) 1.41
Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol (2003) 1.41
A systematic review assessing the effectiveness of alendronate in reducing periprosthetic bone loss after cementless primary THA. Orthopedics (2011) 1.41
Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting. J Biol Chem (2001) 1.39
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? PLoS One (2011) 1.39
GlcNAcylation plays an essential role in breast cancer metastasis. Cancer Res (2010) 1.39
Intravenous Therapies for Complex Regional Pain Syndrome: A Systematic Review. Anesth Analg (2016) 1.39
Activation of Rap1B by G(i) family members in platelets. J Biol Chem (2002) 1.39
Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Mol Syst Biol (2011) 1.38
The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics (2007) 1.38
A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Mol Cancer Ther (2007) 1.36
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A (2010) 1.36
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. J Psychiatry Neurosci (2004) 1.30
Overexpression of SATB1 in laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec (2010) 1.29
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement. Cancer Res (2010) 1.29
A severe combined immunodeficient-hu in vivo mouse model of human primary mantle cell lymphoma. Clin Cancer Res (2008) 1.29
The prion protein family: diversity, rivalry, and dysfunction. Biochim Biophys Acta (2007) 1.28
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood (2007) 1.26
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A (2011) 1.25
Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J Biol Chem (2002) 1.25
Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet (2003) 1.25
Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Res (2013) 1.24
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis (2006) 1.23
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
Transcriptome profiling of resistant and susceptible Cavendish banana roots following inoculation with Fusarium oxysporum f. sp. cubense tropical race 4. BMC Genomics (2012) 1.23
Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood (2010) 1.23
11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease. Nucl Med Biol (2003) 1.22
Visible fluorescent detection of proteins in polyacrylamide gels without staining. Anal Biochem (2004) 1.21
Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood (2005) 1.21