The biochemistry of heme biosynthesis.

Radical S-adenosylmethionine enzymes. Chem Rev (2014) 1.64

Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48

Control of intracellular heme levels: heme transporters and heme oxygenases. Biochim Biophys Acta (2011) 1.48

Structure and function of enzymes in heme biosynthesis. Protein Sci (2010) 1.48

Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics (2009) 1.38

Bacterial heme-transport proteins and their heme-coordination modes. Arch Biochem Biophys (2008) 1.36

Tetrapyrrole Metabolism in Arabidopsis thaliana. Arabidopsis Book (2011) 1.20

Lipoic acid metabolism in microbial pathogens. Microbiol Mol Biol Rev (2010) 1.18

A Bacillus anthracis S-layer homology protein that binds heme and mediates heme delivery to IsdC. J Bacteriol (2010) 1.10

Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2013) 1.08

Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study. PLoS One (2012) 1.08

Heme and blood-feeding parasites: friends or foes? Parasit Vectors (2010) 1.07

Heme transfer to the bacterial cell envelope occurs via a secreted hemophore in the Gram-positive pathogen Bacillus anthracis. J Biol Chem (2009) 1.07

Roles of iron acquisition systems in virulence of extraintestinal pathogenic Escherichia coli: salmochelin and aerobactin contribute more to virulence than heme in a chicken infection model. BMC Microbiol (2012) 1.06

The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma. Toxicol Sci (2009) 1.03

Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency. J Bacteriol (2011) 1.01

Heme and HO-1 Inhibition of HCV, HBV, and HIV. Front Pharmacol (2012) 1.01

Heme biosynthesis is coupled to electron transport chains for energy generation. Proc Natl Acad Sci U S A (2010) 1.00

The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. J Biol Chem (2013) 1.00

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. Free Radic Biol Med (2010) 0.96

The five near-iron transporter (NEAT) domain anthrax hemophore, IsdX2, scavenges heme from hemoglobin and transfers heme to the surface protein IsdC. J Biol Chem (2011) 0.94

Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94

Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential. J Biol Chem (2010) 0.94

Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. Enzyme Res (2011) 0.93

Chlorophyll biosynthesis gene evolution indicates photosystem gene duplication, not photosystem merger, at the origin of oxygenic photosynthesis. Genome Biol Evol (2013) 0.91

The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae. Front Cell Infect Microbiol (2013) 0.91

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metab Rev (2010) 0.90

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. J Bacteriol (2013) 0.89

The near-iron transporter (NEAT) domains of the anthrax hemophore IsdX2 require a critical glutamine to extract heme from methemoglobin. J Biol Chem (2013) 0.89

Iron-dependent functions of mitochondria--relation to neurodegeneration. J Neural Transm (Vienna) (2010) 0.88

The tetrapyrrole biosynthetic pathway and its regulation in Rhodobacter capsulatus. Adv Exp Med Biol (2010) 0.87

Molecular phylogeny and intricate evolutionary history of the three isofunctional enzymes involved in the oxidation of protoporphyrinogen IX. Genome Biol Evol (2014) 0.86

Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris. Microb Cell Fact (2015) 0.85

Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation. MBio (2014) 0.84

Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob Agents Chemother (2009) 0.84

Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway. J Biol Chem (2012) 0.83

The crimson conundrum: heme toxicity and tolerance in GAS. Front Cell Infect Microbiol (2014) 0.83

Reduced expression of cytochrome oxidases largely explains cAMP inhibition of aerobic growth in Shewanella oneidensis. Sci Rep (2016) 0.82

Potential of aerobic denitrification by Pseudomonas stutzeri TR2 to reduce nitrous oxide emissions from wastewater treatment plants. Appl Environ Microbiol (2010) 0.82

Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli. Sci Rep (2015) 0.81

Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi. Front Microbiol (2012) 0.81

Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli. Protein Expr Purif (2010) 0.80

Gene expression profiling in Entamoeba histolytica identifies key components in iron uptake and metabolism. PLoS One (2014) 0.79

Extracellular hemoglobin: the case of a friend turned foe. Front Physiol (2015) 0.79

Role of iron in neurodegenerative diseases. J Neural Transm (Vienna) (2016) 0.79

Coproporphyrin excretion and low thiol levels caused by point mutation in the Rhodobacter sphaeroides S-adenosylmethionine synthetase gene. J Bacteriol (2009) 0.79

One step beyond a ribosome: The ancient anaerobic core. Biochim Biophys Acta (2016) 0.78

In Vivo Curative and Protective Potential of Orally Administered 5-Aminolevulinic Acid plus Ferrous Ion against Malaria. Antimicrob Agents Chemother (2015) 0.78

Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product. Microbiol Mol Biol Rev (2017) 0.77

Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology. Mol Microbiol (2016) 0.77

Comparative analysis of wolbachia genomes reveals streamlining and divergence of minimalist two-component systems. G3 (Bethesda) (2015) 0.76

Thiol redox sensitivity of two key enzymes of heme biosynthesis and pentose phosphate pathways: uroporphyrinogen decarboxylase and transketolase. Oxid Med Cell Longev (2013) 0.76

Leishmania major possesses a unique HemG-type protoporphyrinogen IX oxidase. Biosci Rep (2014) 0.76

Unraveling the mystery of the ring: Tracking heme dynamics in living cells. Proc Natl Acad Sci U S A (2016) 0.75

Comparative transcriptional profiling-based identification of raphanusanin-inducible genes. BMC Plant Biol (2010) 0.75

Global Metabolic Responses to Salt Stress in Fifteen Species. PLoS One (2016) 0.75

Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom. PLoS One (2014) 0.75

In Vitro Optimization of Enzymes Involved in Precorrin-2 Synthesis Using Response Surface Methodology. PLoS One (2016) 0.75

Effect of hydrogen peroxide on the biosynthesis of heme and proteins: potential implications for the partitioning of Glu-tRNA(Glu) between these pathways. Int J Mol Sci (2014) 0.75

Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana. Front Plant Sci (2016) 0.75

Iron-regulated gene ireA in avian pathogenic Escherichia coli participates in adhesion and stress-resistance. BMC Vet Res (2016) 0.75

Mitochondrial control of immunity: beyond ATP. Nat Rev Immunol (2017) 0.75

Systematic bacterialization of yeast genes identifies a near-universally swappable pathway. Elife (2017) 0.75

Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression. J Biol Chem (2017) 0.75

PrediSi: prediction of signal peptides and their cleavage positions. Nucleic Acids Res (2004) 3.93

Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes. Bioinformatics (2005) 2.82

PRODORIC: prokaryotic database of gene regulation. Nucleic Acids Res (2003) 2.81

JCat: a novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res (2005) 2.60

RNA-dependent cysteine biosynthesis in archaea. Science (2005) 2.50

The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea. ISME J (2009) 2.00

Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. EMBO J (2003) 1.98

Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5'- and 3'-halves. Nature (2005) 1.97

Genome sequences of the biotechnologically important Bacillus megaterium strains QM B1551 and DSM319. J Bacteriol (2011) 1.86

Bacillus megaterium--from simple soil bacterium to industrial protein production host. Appl Microbiol Biotechnol (2007) 1.85

Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J (2005) 1.74

JProGO: a novel tool for the functional interpretation of prokaryotic microarray data using Gene Ontology information. Nucleic Acids Res (2006) 1.69

Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol (2004) 1.63

Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. Eur J Biochem (2003) 1.57

SYSTOMONAS--an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Res (2007) 1.55

Structure and function of enzymes in heme biosynthesis. Protein Sci (2010) 1.48

PRODORIC (release 2009): a database and tool platform for the analysis of gene regulation in prokaryotes. Nucleic Acids Res (2008) 1.39

JVirGel: Calculation of virtual two-dimensional protein gels. Nucleic Acids Res (2003) 1.33

The Fnr regulon of Bacillus subtilis. J Bacteriol (2006) 1.29

The anaerobic regulatory network required for Pseudomonas aeruginosa nitrate respiration. J Bacteriol (2007) 1.29

Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Environ Microbiol (2010) 1.24

Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung. Int J Med Microbiol (2010) 1.23

Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli. J Biol Chem (2002) 1.22

Benzoate-coenzyme A ligase from Thauera aromatica: an enzyme acting in anaerobic and aerobic pathways. J Bacteriol (2003) 1.19

ProdoNet: identification and visualization of prokaryotic gene regulatory and metabolic networks. Nucleic Acids Res (2008) 1.18

A short story about a big magic bug. Bioeng Bugs (2010) 1.16

Structure and function of radical SAM enzymes. Curr Opin Chem Biol (2004) 1.16

Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions. BMC Microbiol (2010) 1.15

Production and secretion of recombinant Leuconostoc mesenteroides dextransucrase DsrS in Bacillus megaterium. Biotechnol Bioeng (2005) 1.14

Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium. Biochem J (2003) 1.13

Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2. J Biol Chem (2010) 1.11

Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J Biol Chem (2002) 1.10

MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data. Bioinformatics (2006) 1.10

Genetic tools for the investigation of Roseobacter clade bacteria. BMC Microbiol (2009) 1.07

Bacillus subtilis Fnr senses oxygen via a [4Fe-4S] cluster coordinated by three cysteine residues without change in the oligomeric state. Mol Microbiol (2006) 1.06

Structural and functional comparison of HemN to other radical SAM enzymes. Biol Chem (2005) 1.04

Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif. J Biol Chem (2003) 1.03

Plasmid system for the intracellular production and purification of affinity-tagged proteins in Bacillus megaterium. Biotechnol Bioeng (2007) 1.02

Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines. J Biol Chem (2005) 1.02

TLM-Tracker: software for cell segmentation, tracking and lineage analysis in time-lapse microscopy movies. Bioinformatics (2012) 1.00

Heme biosynthesis is coupled to electron transport chains for energy generation. Proc Natl Acad Sci U S A (2010) 1.00

Members of the genus Arthrobacter grow anaerobically using nitrate ammonification and fermentative processes: anaerobic adaptation of aerobic bacteria abundant in soil. FEMS Microbiol Lett (2003) 1.00

Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins. J Biotechnol (2012) 1.00

The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. J Biol Chem (2006) 1.00

High yield recombinant penicillin G amidase production and export into the growth medium using Bacillus megaterium. Microb Cell Fact (2006) 0.99

ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis. J Biol Chem (2008) 0.99

The Bacillus subtilis nrdEF genes, encoding a class Ib ribonucleotide reductase, are essential for aerobic and anaerobic growth. Appl Environ Microbiol (2006) 0.99

A Bacillus megaterium plasmid system for the production, export, and one-step purification of affinity-tagged heterologous levansucrase from growth medium. Appl Environ Microbiol (2006) 0.99

Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese. J Biol Chem (2003) 0.99

Metabolic engineering of cobalamin (vitamin B12) production in Bacillus megaterium. Microb Biotechnol (2009) 0.99

Crystal structure of a non-discriminating glutamyl-tRNA synthetase. J Mol Biol (2006) 0.99

Bacillus subtilis ResD induces expression of the potential regulatory genes yclJK upon oxygen limitation. J Bacteriol (2004) 0.99

Coexpression of the type I signal peptidase gene sipM increases recombinant protein production and export in Bacillus megaterium MS941. Biotechnol Bioeng (2005) 0.98

High-yield intra- and extracellular protein production using Bacillus megaterium. Appl Environ Microbiol (2010) 0.97

Genotypic and phenotypic characterization of Pseudomonas aeruginosa isolates from urinary tract infections. Int J Med Microbiol (2010) 0.97

Regulation of heme biosynthesis in non-phototrophic bacteria. J Mol Microbiol Biotechnol (2002) 0.96

A T7 RNA polymerase-dependent gene expression system for Bacillus megaterium. Appl Microbiol Biotechnol (2009) 0.95

A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence. Archaea (2010) 0.95

The transcription factor AlsR binds and regulates the promoter of the alsSD operon responsible for acetoin formation in Bacillus subtilis. J Bacteriol (2011) 0.94

Insights into polymer versus oligosaccharide synthesis: mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium. Biochem J (2007) 0.94

Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis. J Biol Chem (2005) 0.93

Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis. J Mol Biol (2006) 0.93

You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae. ISME J (2013) 0.93

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism. J Mol Biol (2002) 0.93

Mechanism of a GatCAB amidotransferase: aspartyl-tRNA synthetase increases its affinity for Asp-tRNA(Asn) and novel aminoacyl-tRNA analogues are competitive inhibitors. Biochemistry (2007) 0.93

Systems biology of recombinant protein production using Bacillus megaterium. Methods Enzymol (2011) 0.92

Genome Sequence of the Acute Urethral Catheter Isolate Pseudomonas aeruginosa MH38. Genome Announc (2014) 0.90

tRNA recognition by glutamyl-tRNA reductase. J Biol Chem (2004) 0.90

Export, purification, and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium. Appl Microbiol Biotechnol (2007) 0.90

Heme biosynthesis in Methanosarcina barkeri via a pathway involving two methylation reactions. J Bacteriol (2006) 0.90

Codon optimized Thermobifida fusca hydrolase secreted by Bacillus megaterium. Biotechnol Bioeng (2007) 0.89

Regulation of the anaerobic metabolism in Bacillus subtilis. Adv Microb Physiol (2012) 0.89

JVirGel 2.0: computational prediction of proteomes separated via two-dimensional gel electrophoresis under consideration of membrane and secreted proteins. Bioinformatics (2006) 0.88

Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex. Proc Natl Acad Sci U S A (2013) 0.87

Regulatory and metabolic networks for the adaptation of Pseudomonas aeruginosa biofilms to urinary tract-like conditions. PLoS One (2013) 0.87

Nitrate-responsive NarX-NarL represses arginine-mediated induction of the Pseudomonas aeruginosa arginine fermentation arcDABC operon. Microbiology (2008) 0.86

Chimeric nitrogenase-like enzymes of (bacterio)chlorophyll biosynthesis. J Biol Chem (2009) 0.86

Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate. J Biol Chem (2002) 0.86

Substrate recognition of nitrogenase-like dark operative protochlorophyllide oxidoreductase from Prochlorococcus marinus. J Biol Chem (2008) 0.86

ROSY--a flexible and universal database and bioinformatics tool platform for Roseobacter related species. In Silico Biol (2008) 0.86

Aspartate 141 is the fourth ligand of the oxygen-sensing [4Fe-4S]2+ cluster of Bacillus subtilis transcriptional regulator Fnr. J Biol Chem (2010) 0.85

Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa. FEMS Microbiol Lett (2010) 0.85

Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs. J Biol Chem (2011) 0.85

Aminolaevulinic acid synthase of Rhodobacter capsulatus: high-resolution kinetic investigation of the structural basis for substrate binding and catalysis. Biochem J (2013) 0.84

Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob Agents Chemother (2009) 0.84

Gene regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen depletion. J Biol Chem (2014) 0.84

Transposon mutagenesis identified chromosomal and plasmid genes essential for adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions. J Bacteriol (2013) 0.84

Co-ordination of iron acquisition, iron porphyrin chelation and iron-protoporphyrin export via the cytochrome c biogenesis protein CcmC in Pseudomonas fluorescens. Microbiology (2003) 0.83

Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida. Microb Cell Fact (2014) 0.83

High yield production of extracellular recombinant levansucrase by Bacillus megaterium. Appl Microbiol Biotechnol (2012) 0.82

Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium. J Biotechnol (2007) 0.82

Biosynthesis of (bacterio)chlorophylls: ATP-dependent transient subunit interaction and electron transfer of dark operative protochlorophyllide oxidoreductase. J Biol Chem (2010) 0.82

Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Biochem J (2008) 0.82