Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMC 3991114)

Published in Atherosclerosis on December 30, 2010

Authors

Angelo Scuteri1, Marco Orru, Christopher Morrell, Maria Grazia Piras, Dennis Taub, David Schlessinger, Manuela Uda, Edward G Lakatta

Author Affiliations

1: National Institute on Aging Intramural Research Program, NIH, Baltimore, USA. angeloelefante@interfree.it

Articles citing this

Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. Atherosclerosis (2011) 1.06

Arterial stiffness and influences of the metabolic syndrome: a cross-countries study. Atherosclerosis (2014) 0.98

Association of age-related changes in circulating intermediary lipid metabolites, inflammatory and oxidative stress markers, and arterial stiffness in middle-aged men. Age (Dordr) (2012) 0.92

Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study). PLoS One (2011) 0.87

Association of serum leptin levels with central arterial stiffness in coronary artery disease patients. BMC Cardiovasc Disord (2016) 0.84

Bringing prevention in geriatrics: evidences from cardiovascular medicine supporting the new challenge. Exp Gerontol (2012) 0.83

Follow-ups of metabolic, inflammatory and oxidative stress markers, and brachial-ankle pulse wave velocity in middle-aged subjects without metabolic syndrome. Clin Exp Hypertens (2012) 0.82

Opiate dependence as an independent and interactive risk factor for arterial stiffness and cardiovascular ageing - a longitudinal study in females. J Clin Med Res (2013) 0.82

Circulating Adipokines and Vascular Function: Cross-Sectional Associations in a Community-Based Cohort. Hypertension (2015) 0.81

Cytokines and metabolic syndrome: the perfect storm for arterial aging. Atherosclerosis (2011) 0.78

Blunted nocturnal cortisol rise is associated with higher carotid artery intima-media thickness (CIMT) in overweight African American and Latino youth. Psychoneuroendocrinology (2013) 0.77

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population. Eur Radiol (2016) 0.77

Correlative association of interleukin-6 with intima media thickness: a meta-analysis. Int J Clin Exp Med (2015) 0.76

Acceleration of cardiovascular-biological age by amphetamine exposure is a power function of chronological age. Heart Asia (2017) 0.75

Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies. Eur Thyroid J (2015) 0.75

Articles cited by this

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA (2001) 118.65

Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19

Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 7.50

Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab (1998) 7.05

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96

Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation (1998) 4.89

Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol (2004) 2.91

Novel clinical markers of vascular wall inflammation. Circ Res (2001) 2.80

Inflammation, hypertension, and the metabolic syndrome. JAMA (2003) 2.57

The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes (2001) 2.47

C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol (2004) 2.37

Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension (2003) 2.32

Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation (2002) 2.30

Leptin and atherosclerosis. Atherosclerosis (2006) 1.95

The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study. Diabetes Care (2005) 1.76

Plasma adiponectin levels and sonographic phenotypes of subclinical carotid artery atherosclerosis: data from the SAPHIR Study. Stroke (2005) 1.73

Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension (2005) 1.67

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. Eur Heart J (2007) 1.63

Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women. J Clin Endocrinol Metab (2006) 1.16

C-reactive protein and arterial stiffness in older adults: the Rotterdam Study. Atherosclerosis (2004) 1.15

Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. J Clin Endocrinol Metab (2005) 1.13

The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study. Eur Heart J (2009) 1.10

Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients. Eur Heart J (2007) 1.10

Adiponectin and atherosclerotic disease. Clin Chim Acta (2004) 1.08

Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population: the SardiNIA Study. Nutr Metab Cardiovasc Dis (2009) 1.08

Longitudinal paths to the metabolic syndrome: can the incidence of the metabolic syndrome be predicted? The Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci (2009) 1.05

Plasma adiponectin levels in relation to carotid intima media thickness and markers of insulin resistance. Arterioscler Thromb Vasc Biol (2006) 1.03

Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome. Nutr Metab Cardiovasc Dis (2007) 1.01

Articles by these authors

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55

Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

The DNA sequence of the human X chromosome. Nature (2005) 6.97

Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation (2005) 6.89

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69

beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res (2002) 4.66

Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation (2005) 4.61

PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46

Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56

Arterial aging: is it an immutable cardiovascular risk factor? Hypertension (2005) 3.55

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51

Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J Hypertens (2009) 3.47

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18

New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol (2004) 2.91

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am J Physiol Heart Circ Physiol (2009) 2.89

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks. J Am Coll Cardiol (2013) 2.79

Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol (2008) 2.75