Published in Nat Genet on May 09, 2010
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
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Population based study of 12 autoimmune diseases in Sardinia, Italy: prevalence and comorbidity. PLoS One (2012) 1.12
Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. Int J Mol Sci (2011) 1.11
Rare variant genotype imputation with thousands of study-specific whole-genome sequences: implications for cost-effective study designs. Eur J Hum Genet (2014) 1.01
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Genetic risk variants in African Americans with multiple sclerosis. Neurology (2013) 0.99
Genetic burden in multiple sclerosis families. Genes Immun (2013) 0.97
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Revealing the genetic basis of multiple sclerosis: are we there yet? Curr Opin Genet Dev (2011) 0.93
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Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populations. PLoS One (2012) 0.90
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Cbl exposes its RING finger. Nat Struct Mol Biol (2012) 0.87
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol (2013) 0.87
Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. PLoS One (2012) 0.87
The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico. PLoS One (2014) 0.87
A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res (2012) 0.86
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. Cell Cycle (2014) 0.86
Identity-by-descent mapping to detect rare variants conferring susceptibility to multiple sclerosis. PLoS One (2013) 0.85
Association of SNPs of CD40 gene with multiple sclerosis in Russians. PLoS One (2013) 0.85
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. Int J Mol Sci (2013) 0.84
Next-generation sequencing in understanding complex neurological disease. Expert Rev Neurother (2013) 0.84
Genotype imputation for African Americans using data from HapMap phase II versus 1000 genomes projects. Genet Epidemiol (2012) 0.83
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Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. PLoS One (2013) 0.81
Progress in multiple sclerosis genetics. Curr Genomics (2012) 0.81
GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases. Chin J Cancer (2011) 0.81
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Genome-wide association studies in neurology. Ann Transl Med (2014) 0.80
Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis. PLoS One (2012) 0.80
Single nucleotide polymorphism (SNP)-strings: an alternative method for assessing genetic associations. PLoS One (2014) 0.79
Haplotype-based approach to known MS-associated regions increases the amount of explained risk. J Med Genet (2015) 0.78
SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun (2011) 0.77
Functional relevance for multiple sclerosis-associated genetic variants. Immunogenetics (2014) 0.77
Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720. Clin Immunol (2015) 0.77
Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta (2015) 0.77
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Sci Adv (2016) 0.77
Genome-wide association study of susceptibility loci for breast cancer in Sardinian population. BMC Cancer (2015) 0.77
Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population. Chin Med J (Engl) (2015) 0.75
Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity. Inflamm Cell Signal (2015) 0.75
Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance. World J Diabetes (2017) 0.75
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Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet (2009) 4.97
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08
Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89
The epidemiology of multiple sclerosis in Europe. Eur J Neurol (2006) 2.80
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet (2002) 1.63
Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia. Hum Mol Genet (2001) 1.60
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proc Natl Acad Sci U S A (2009) 1.34
Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin Immunol (2007) 1.17
Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol (2007) 1.16
Activation of T cells: releasing the brakes by proteolytic elimination of Cbl-b. Sci Signal (2009) 1.05
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
A global reference for human genetic variation. Nature (2015) 12.85
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Widespread RNA and DNA sequence differences in the human transcriptome. Science (2011) 11.45
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31