Published in Blood on February 01, 2011
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice. Blood (2013) 1.72
Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms. Blood (2013) 1.50
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology. Hematol Oncol Clin North Am (2012) 1.14
A congenital neutrophil defect syndrome associated with mutations in VPS45. N Engl J Med (2013) 0.92
Inherited bone marrow failure syndromes in adolescents and young adults. Ann Med (2014) 0.88
The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Curr Opin Hematol (2015) 0.86
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. J Clin Invest (2015) 0.84
Hematopoietic stem cell transplantation for severe congenital neutropenia. Curr Opin Hematol (2012) 0.81
Understanding, treating and avoiding hematological disease: better medicine through mathematics? Bull Math Biol (2014) 0.77
Animal models of human granulocyte diseases. Hematol Oncol Clin North Am (2012) 0.76
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo. PLoS One (2016) 0.75
A Truncated G-CSFR Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: Implication for Understanding CSF3R Mutations in Severe Congenital Neutropenia. J Biol Chem (2017) 0.75
Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol (2002) 5.36
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood (2006) 5.21
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood (2010) 4.84
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet (2000) 4.48
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med (1998) 4.04
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood (2000) 3.45
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet (2006) 3.03
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med (2008) 2.99
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nat Genet (2001) 2.70
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest (2002) 2.56
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res (2007) 2.50
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet (2003) 2.43
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37
A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med (2009) 2.30
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature (2008) 2.10
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response. Blood (2006) 1.93
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood (2007) 1.92
Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia. Br J Haematol (2001) 1.78
Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register. Blood (2004) 1.70
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. Br J Haematol (2009) 1.59
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes (2004) 1.50
Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta. J Clin Invest (2007) 1.41
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. Br J Haematol (2007) 1.37
Characterization of mutant neutrophil elastase in severe congenital neutropenia. J Biol Chem (2001) 1.26
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations. Hum Mutat (2006) 1.17
Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments. FEBS Lett (2005) 1.15
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Blood (2002) 1.09
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia. Blood (2002) 0.99
Carboxyl-terminal prodomain-deleted human leukocyte elastase and cathepsin G are efficiently targeted to granules and enzymatically activated in the rat basophilic/mast cell line RBL. J Biol Chem (1995) 0.92
Bortezomib in the treatment of cancer. Recent Pat Anticancer Drug Discov (2006) 0.91
Severe congenital neutropenia and the unfolded protein response. Curr Opin Hematol (2008) 0.87
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature (2008) 38.13
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07
The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66
Clonal architecture of secondary acute myeloid leukemia. N Engl J Med (2012) 6.71
Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A (2009) 4.17
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. JAMA (2011) 4.11
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet (2011) 4.02
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood (2008) 3.89
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol (2006) 3.17
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood (2008) 3.11
Pharmacological interventions for clozapine-induced hypersalivation. Cochrane Database Syst Rev (2008) 2.88
Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron (2006) 2.79
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity (2002) 2.72
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. J Clin Invest (2009) 2.66
Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron (2005) 2.50
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest (2010) 2.38
Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity. J Neurosci (2006) 2.34
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood (2009) 2.25
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood (2004) 2.01
Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron (2011) 2.00
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med (2011) 1.96
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood (2007) 1.92
Regulation of neutrophil homeostasis. Curr Opin Hematol (2007) 1.87
CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood (2009) 1.83
Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Res (2010) 1.75
Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe. Angew Chem Int Ed Engl (2011) 1.70
Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo. J Biomed Opt (2012) 1.69
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A (2003) 1.69
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood (2006) 1.66
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. Br J Haematol (2009) 1.59
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome. Blood (2004) 1.58
Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapses. J Neurosci (2007) 1.56
A mouse-based strategy for cyclophosphamide pharmacogenomic discovery. J Appl Physiol (1985) (2003) 1.55
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood (2007) 1.55
Chromium contamination accident in China: viewing environment policy of China. Environ Sci Technol (2011) 1.51
Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol (2002) 1.48
Interventions for treating depression after stroke. Cochrane Database Syst Rev (2008) 1.46
Chinese herbal medicine for schizophrenia: cochrane systematic review of randomised trials. Br J Psychiatry (2007) 1.45
Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood (2003) 1.44
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J Clin Invest (2009) 1.44
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nat Neurosci (2010) 1.43
Acupuncture for schizophrenia. Cochrane Database Syst Rev (2014) 1.43
Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res (2008) 1.42
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat Neurosci (2009) 1.42
Genomics of AML: clinical applications of next-generation sequencing. Hematology Am Soc Hematol Educ Program (2011) 1.41
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest (2008) 1.41
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40
The many causes of severe congenital neutropenia. N Engl J Med (2009) 1.40
Retrospective respiration-gated whole-body photoacoustic computed tomography of mice. J Biomed Opt (2014) 1.39
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. Br J Haematol (2007) 1.37
Structure and function of PICK1. Neurosignals (2007) 1.35
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood (2012) 1.33
Transcriptome analysis and comparison reveal divergence between two invasive whitefly cryptic species. BMC Genomics (2011) 1.31
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol (2013) 1.31
IMP3 is a novel prognostic marker that correlates with colon cancer progression and pathogenesis. Ann Surg Oncol (2009) 1.29
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood (2006) 1.29
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential. Blood (2007) 1.25
Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. Neuroimage (2012) 1.25
Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography. J Biomed Opt (2012) 1.24
Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol (2010) 1.24
Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J Neurosci (2006) 1.23
Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem (2006) 1.23
BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant J (2009) 1.22
An Improved Cloud Classification Algorithm for China's FY-2C Multi-Channel Images Using Artificial Neural Network. Sensors (Basel) (2009) 1.21
Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J (2007) 1.20
Endothelial cell signaling during conducted vasomotor responses. Am J Physiol Heart Circ Physiol (2003) 1.20
Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. J Leukoc Biol (2008) 1.20
Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Res (2009) 1.20
Commonly dysregulated genes in murine APL cells. Blood (2006) 1.18
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy. Br J Haematol (2010) 1.17
A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice. Exp Hematol (2011) 1.17
Regulation of hematopoietic stem cell activity by inflammation. Front Immunol (2013) 1.17
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. J Neurosci (2007) 1.16
Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood (2010) 1.16
High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain. Proc Natl Acad Sci U S A (2013) 1.15
Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock. Crit Care Med (2003) 1.12
Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Phys Rev Lett (2013) 1.09
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Blood (2002) 1.09
Water quantity and quality optimization modeling of dams operation based on SWAT in Wenyu River Catchment, China. Environ Monit Assess (2010) 1.08
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nat Struct Mol Biol (2005) 1.07
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood (2006) 1.06
Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci U S A (2005) 1.06
Regulation of neutrophil trafficking from the bone marrow. Cell Mol Life Sci (2011) 1.03
Small-animal whole-body photoacoustic tomography: a review. IEEE Trans Biomed Eng (2013) 1.02
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration. EMBO J (2011) 0.98
miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver. Med Oncol (2011) 0.96
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother (2014) 0.96