Regulation of neutrophil homeostasis.

Acute lower respiratory tract infection. N Engl J Med (2008) 3.70

The neutrophil in vascular inflammation. Nat Med (2011) 2.84

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A (2010) 2.77

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest (2010) 2.38

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest (2012) 2.18

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood (2009) 1.83

Homeostatic regulation of blood neutrophil counts. J Immunol (2008) 1.81

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol (2009) 1.80

Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). PLoS Genet (2011) 1.75

Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med (2009) 1.58

Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol (2010) 1.54

Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog (2015) 1.35

Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol (2011) 1.21

Bone marrow and the control of immunity. Cell Mol Immunol (2011) 1.15

The role of chemokines in acute liver injury. Front Physiol (2012) 1.09

Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc Natl Acad Sci U S A (2009) 1.08

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol (2009) 1.07

Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland. Dev Genes Evol (2011) 1.06

CXCR2 in acute lung injury. Mediators Inflamm (2012) 1.02

Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans. Theor Biol Med Model (2012) 0.99

Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. J Biol Chem (2012) 0.98

Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity (2010) 0.98

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. J Leukoc Biol (2013) 0.98

Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice. J Immunol (2010) 0.95

Novel role for aldose reductase in mediating acute inflammatory responses in the lung. J Immunol (2009) 0.94

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer. Br J Cancer (2013) 0.93

Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia. J Hepatol (2007) 0.92

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood (2010) 0.91

Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. PLoS Negl Trop Dis (2011) 0.90

Neutrophilia and elevated serum cytokines are implicated in glycogen storage disease type Ia. FEBS Lett (2007) 0.90

The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model. Gravit Space Res (2013) 0.89

Zoledronate and pamidronate depress neutrophil functions and survival in mice. Br J Pharmacol (2012) 0.89

Differential inflammatory response to inhaled lipopolysaccharide targeted either to the airways or the alveoli in man. PLoS One (2012) 0.88

Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem (2011) 0.88

Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species. PLoS One (2013) 0.88

Cell biology and clinical promise of G-CSF: immunomodulation and neuroprotection. J Cell Mol Med (2008) 0.86

CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis. Exp Eye Res (2009) 0.83

Neutrophil migration under normal and sepsis conditions. Cardiovasc Hematol Disord Drug Targets (2015) 0.83

Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. J Immunol (2012) 0.82

Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis. Immunology (2014) 0.82

Stress-induced effects, which inhibit host defenses, alter leukocyte trafficking. Cell Stress Chaperones (2012) 0.81

The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus. Arthritis Res Ther (2013) 0.81

5-lipoxygenase-dependent recruitment of neutrophils and macrophages by eotaxin-stimulated murine eosinophils. Mediators Inflamm (2014) 0.80

Immunological cells and functions in Gaucher disease. Crit Rev Oncog (2013) 0.80

CMV-specific T cell isolation from G-CSF mobilized peripheral blood: depletion of myeloid progenitors eliminates non-specific binding of MHC-multimers. J Transl Med (2014) 0.79

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. Haematologica (2015) 0.78

Neutrophils, hypercholesterolemia, and atherogenesis. Circulation (2010) 0.78

Understanding, treating and avoiding hematological disease: better medicine through mathematics? Bull Math Biol (2014) 0.77

Neutrophil biology and the next generation of myeloid growth factors. J Natl Compr Canc Netw (2009) 0.77

G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med (2016) 0.77

New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction. Burns Trauma (2014) 0.77

Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β. PLoS One (2013) 0.76

Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. Adv Biol Regul (2016) 0.75

The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo. Cell Cycle (2013) 0.75

Site-Specific Neutrophil Migration and CXCL2 Expression in Periodontal Tissue. J Dent Res (2016) 0.75

Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy. Proc Natl Acad Sci U S A (2016) 0.75

Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties. FEBS Open Bio (2015) 0.75

Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes. BMC Vet Res (2016) 0.75

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature (2008) 38.13

Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33

DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07

The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66

Clonal architecture of secondary acute myeloid leukemia. N Engl J Med (2012) 6.71

Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A (2009) 4.17

Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. JAMA (2011) 4.11

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet (2011) 4.02

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood (2008) 3.89

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76

The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol (2006) 3.17

Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood (2008) 3.11

G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity (2002) 2.72

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. J Clin Invest (2009) 2.66

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest (2010) 2.38

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood (2009) 2.25

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12

Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood (2004) 2.01

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med (2011) 1.96

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood (2007) 1.92

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood (2009) 1.83

Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Res (2010) 1.75

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A (2003) 1.69

G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood (2006) 1.66

Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. Br J Haematol (2009) 1.59

Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome. Blood (2004) 1.58

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery. J Appl Physiol (1985) (2003) 1.55

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood (2007) 1.55

Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol (2002) 1.48

Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood (2003) 1.44

Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res (2008) 1.42

Genomics of AML: clinical applications of next-generation sequencing. Hematology Am Soc Hematol Educ Program (2011) 1.41

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest (2008) 1.41

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40

The many causes of severe congenital neutropenia. N Engl J Med (2009) 1.40

Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. Br J Haematol (2007) 1.37

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood (2012) 1.33

Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood (2006) 1.29

Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential. Blood (2007) 1.25

Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem (2006) 1.23

Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. J Leukoc Biol (2008) 1.20

Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Res (2009) 1.20

Commonly dysregulated genes in murine APL cells. Blood (2006) 1.18

Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy. Br J Haematol (2010) 1.17

A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice. Exp Hematol (2011) 1.17

Regulation of hematopoietic stem cell activity by inflammation. Front Immunol (2013) 1.17

Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood (2010) 1.16

Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Blood (2002) 1.09

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood (2006) 1.06

Regulation of neutrophil trafficking from the bone marrow. Cell Mol Life Sci (2011) 1.03

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother (2014) 0.96

Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane. Blood (2011) 0.93

Dicer and outcomes in patients with acute myeloid leukemia (AML). Leuk Res (2009) 0.91

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood (2012) 0.90

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis. Blood (2011) 0.90

Inherited bone marrow failure syndromes in adolescents and young adults. Ann Med (2014) 0.88

Severe congenital neutropenia and the unfolded protein response. Curr Opin Hematol (2008) 0.87

Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. J Leukoc Biol (2010) 0.86

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Curr Opin Hematol (2015) 0.86

Niche competition and cancer metastasis to bone. J Clin Invest (2011) 0.85

Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. Blood (2013) 0.84

Cellular complexity of the bone marrow hematopoietic stem cell niche. Calcif Tissue Int (2013) 0.80

5. Mechanisms of disordered granulopoiesis in congenital neutropenia. Curr Top Dev Biol (2006) 0.79

Enhancing hematopoietic growth factor performance. Nat Med (2012) 0.78

p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation. J Leukoc Biol (2006) 0.77

CXCR2 is the Tpo of the iceberg. Blood (2011) 0.76

Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML. PLoS One (2008) 0.76

Neutrophil differentiation. Haematologica (2005) 0.75

A comparison of cyclic neutropenia in childhood and severe congenital neutropenia. Haematologica (2005) 0.75