Published in Hum Mol Genet on March 04, 2011
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension (2011) 1.89
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet (2011) 1.54
Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy. Front Genet (2012) 1.40
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27
Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Renal Physiol (2011) 1.25
GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol (2013) 1.14
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. Am J Hum Genet (2014) 1.12
Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J (2013) 1.07
Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury. Am J Physiol Renal Physiol (2014) 1.07
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS One (2012) 1.03
Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Proc Natl Acad Sci U S A (2014) 1.01
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. PLoS One (2012) 0.99
12q24 locus association with type 1 diabetes: SH2B3 or ATXN2? World J Diabetes (2014) 0.95
Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans. BMC Med Genet (2012) 0.95
Practical barriers and ethical challenges in genetic data sharing. Int J Environ Res Public Health (2014) 0.89
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Front Genet (2013) 0.88
Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension. Curr Hypertens Rep (2011) 0.87
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc Res (2012) 0.87
Carotid baroreflex responsiveness is impaired in normotensive African American men. Am J Physiol Heart Circ Physiol (2011) 0.87
Genetic epidemiology of type 2 diabetes and cardiovascular diseases in Africa. Prog Cardiovasc Dis (2013) 0.86
Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies. Circ Res (2012) 0.86
Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics (2015) 0.86
Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. Int J Biol Sci (2012) 0.85
Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping. J Hypertens (2012) 0.84
Advancing management of hypertension through pharmacogenomics. Ann Med (2012) 0.84
Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction. J Clin Lipidol (2012) 0.84
Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics (2014) 0.84
Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine. Curr Pharmacogenomics Person Med (2011) 0.83
Power comparison of admixture mapping and direct association analysis in genome-wide association studies. Genet Epidemiol (2012) 0.83
Carotid baroreflex responsiveness in normotensive African Americans is attenuated at rest and during dynamic leg exercise. Front Physiol (2013) 0.82
P2Y receptors and kidney function. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.82
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat Genet (2016) 0.81
Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC). PLoS One (2015) 0.81
Capacity-Building for Career Paths in Public Health and Biomedical Research for Undergraduate Minority Students: A Jackson Heart Study Success Model. Ethn Dis (2016) 0.81
Genetics of hypertension: discoveries from the bench to human populations. Am J Physiol Renal Physiol (2013) 0.80
Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate. Neurogenetics (2015) 0.80
A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. Sci Rep (2016) 0.80
Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction. J Transl Med (2013) 0.79
The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis. Biol Res Nurs (2016) 0.79
A review of genetics, arterial stiffness, and blood pressure in African Americans. J Cardiovasc Transl Res (2012) 0.79
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function. PLoS Genet (2014) 0.78
Prevalence of hypertension in the Gambia and Sierra Leone, western Africa: a cross-sectional study. Cardiovasc J Afr (2014) 0.78
Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults. Nutrients (2017) 0.77
Impact of interactions between risk alleles on clinical endpoints in hypertension. Heart Asia (2016) 0.76
Mapping Novel Pathways in Cardiovascular Disease Using eQTL Data: The Past, Present, and Future of Gene Expression Analysis. Front Genet (2013) 0.76
Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review. J Hum Hypertens (2015) 0.76
Body mass index modulates blood pressure heritability: the Family Blood Pressure Program. Am J Hypertens (2013) 0.76
Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study. BMC Cardiovasc Disord (2014) 0.75
Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry. J Hypertens (2017) 0.75
Attitudes toward Genetic Testing for Hypertension among African American Women and Girls. Nurs Res Pract (2013) 0.75
Association of Parental Hypertension With Arterial Stiffness in Nonhypertensive Offspring: The Framingham Heart Study. Hypertension (2016) 0.75
Association of polymorphisms in the aldosterone-regulated sodium reabsorption pathway with blood pressure among Hispanics. BMC Proc (2016) 0.75
Functional implications of Neandertal introgression in modern humans. Genome Biol (2017) 0.75
The function of SH2B3 (LNK) in the kidney. Am J Physiol Renal Physiol (2016) 0.75
Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans. PLoS One (2016) 0.75
Genetic Loci and Novel Discrimination Measures Associated with Blood Pressure Variation in African Americans Living in Tallahassee. PLoS One (2016) 0.75
Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population. Aging Dis (2015) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample. J Hum Hypertens (2014) 0.75
A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions. Curr Hypertens Rep (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 19.43
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension (2008) 7.99
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med (2005) 6.99
Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78
Racial disparities in hypertension prevalence, awareness, and management. Arch Intern Med (2005) 5.09
A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet (2009) 4.28
GWAF: an R package for genome-wide association analyses with family data. Bioinformatics (2009) 3.81
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J (2007) 2.04
Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet (2010) 1.90
Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res (2008) 1.88
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Mol Psychiatry (2010) 1.39
Admixture mapping provides evidence of association of the VNN1 gene with hypertension. PLoS One (2007) 1.31
PPARs: the vasculature, inflammation and hypertension. Curr Opin Nephrol Hypertens (2009) 1.28
A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem (2009) 1.26
Luminal P2Y2 receptor-mediated inhibition of Na+ absorption in isolated perfused mouse CCD. J Am Soc Nephrol (2002) 1.24
Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Am J Respir Cell Mol Biol (2006) 1.18
African American women and men at high and low risk for hypertension: a signal detection analysis of NHANES III, 1988-1994. Prev Med (2002) 1.16
Programmed hypertension: kidney, brain or both? Trends Endocrinol Metab (2002) 0.99
CAR-diology--a virus receptor in the healthy and diseased heart. J Mol Med (Berl) (2009) 0.97
Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins. J Am Soc Nephrol (2005) 0.90
Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels. Cell Physiol Biochem (2009) 0.86
Association of the purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene with myocardial infarction in Japanese men. Circ J (2009) 0.79
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med (2002) 21.28
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med (2008) 18.34
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 17.18
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Genes mirror geography within Europe. Nature (2008) 14.23
A controlled trial of renal denervation for resistant hypertension. N Engl J Med (2014) 14.22
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Obesity and the risk of heart failure. N Engl J Med (2002) 12.58
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 10.24
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Demonstrating stratification in a European American population. Nat Genet (2005) 9.49
The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol (2004) 9.43
Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation (2010) 9.09
Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA (2003) 9.06
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 8.90
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation (2004) 8.80
Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med (2012) 8.68
Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation (2002) 8.49
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension (2004) 8.27
Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med (2011) 8.19
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. JAMA (2003) 8.18
Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA (2004) 8.12
Haplotype inference in random population samples. Am J Hum Genet (2002) 8.07
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89
The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods. J Am Soc Nephrol (2003) 7.79
Association of weight status with mortality in adults with incident diabetes. JAMA (2012) 7.49