Published in Proc Natl Acad Sci U S A on January 13, 2005
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A (2011) 1.90
Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res (2007) 1.47
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol (2008) 1.35
Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. Mol Cell Biol (2006) 1.30
Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol Cell Biol (2006) 1.23
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY) (2011) 1.21
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc Natl Acad Sci U S A (2008) 1.14
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One (2010) 1.10
Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem (2009) 1.08
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Cell Cycle (2010) 1.06
DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1. Oncotarget (2015) 1.04
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. Nucleic Acids Res (2009) 1.00
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem (2011) 0.97
Mitotic crisis: the unmasking of a novel role for RPA. Cell Cycle (2009) 0.96
A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle (2014) 0.92
Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci (2010) 0.92
Inhibition of the mitotic exit network in response to damaged telomeres. PLoS Genet (2013) 0.91
Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome. Leuk Res (2013) 0.90
Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta (2011) 0.89
DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. Chem Res Toxicol (2010) 0.89
DNA damage-induced cell death is enhanced by progression through mitosis. Cell Cycle (2009) 0.88
Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe. Cell Death Dis (2014) 0.88
Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining. Cell Death Dis (2014) 0.84
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells. Cell Death Differ (2010) 0.83
CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. Cancer Res (2012) 0.82
Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation. Nucleic Acids Res (2013) 0.82
Changes in allelic imbalances in locally advanced breast cancers after chemotherapy. Br J Cancer (2007) 0.80
Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget (2015) 0.79
Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol (2015) 0.78
Powerful inner/outer controlled multi-target magnetic nanoparticle drug carrier prepared by liquid photo-immobilization. Sci Rep (2014) 0.77
Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells. Cell Cycle (2014) 0.77
Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget (2015) 0.77
Upgrading gemcitabine with recycled kinase inhibitors. Cell Cycle (2014) 0.76
DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway. Int J Biol Sci (2015) 0.75
Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry. Cell Cycle (2016) 0.75
Indicators of replicative damage in equine tendon fibroblast monolayers. BMC Vet Res (2013) 0.75
PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment. Autophagy (2017) 0.75
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo. Acta Pharm Sin B (2016) 0.75
Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process. Oncotarget (2017) 0.75
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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
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Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell (2000) 4.01
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Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol (2000) 3.49
Regulation of the APC and the exit from mitosis. Nat Cell Biol (1999) 3.21
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet (2002) 3.11
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat (2001) 2.97
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell (2000) 2.95
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res (1999) 2.67
Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN. Trends Cell Biol (2001) 2.47
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene (1999) 2.34
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell (2001) 2.33
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc Natl Acad Sci U S A (1997) 2.19
DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Curr Biol (2002) 2.15
Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev (1999) 2.14
RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast. EMBO J (1999) 2.05
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A (2001) 1.96
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Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. J Biol Chem (2001) 1.47
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev (2001) 1.40
The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit. Curr Biol (2000) 1.36
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol (2001) 1.36
Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem (2003) 1.35
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Neither p21WAF1 nor 14-3-3sigma prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells. Cancer Res (2001) 1.31
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MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast. Bioessays (2002) 0.95
Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation. J Mol Cell Cardiol (1997) 0.94
ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cells. FEBS Lett (1997) 0.83
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Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res (2013) 6.89
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol (2008) 2.53
GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol (2008) 2.45
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum Mol Genet (2006) 2.15
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98
Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97
Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod (2012) 1.88
p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol (2006) 1.81
Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest (2014) 1.71
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67
Comparative safety of periablation anticoagulation strategies for atrial fibrillation: data from a large multicenter study. Pacing Clin Electrophysiol (2014) 1.60
A major predisposition locus for severe obesity, at 4p15-p14. Am J Hum Genet (2002) 1.60
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Dynamic gene expression during the onset of myoblast differentiation in vitro. Genomics (2003) 1.36
The function of APC/CCdh1 in cell cycle and beyond. Cell Div (2009) 1.35
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol (2007) 1.32
Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell (2005) 1.21
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med (2014) 1.18
BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet (2010) 1.18
The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol Cell Biol (2007) 1.17
Aneuploidy and tumorigenesis. Semin Cell Dev Biol (2011) 1.15
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest (2014) 1.03
A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci (2011) 1.03
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol (2011) 1.00
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation. Mol Oncol (2013) 1.00
The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest (2004) 1.00
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol (2012) 1.00
Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol (2010) 1.00
A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci U S A (2006) 0.99
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem (2011) 0.97
Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol (2008) 0.95
Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology (2010) 0.90
Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res (2008) 0.89
Transgenic RNA interference in mice. Physiology (Bethesda) (2007) 0.88
The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression. Cell Cycle (2011) 0.88
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol Cell Biol (2009) 0.88
Voluven, a new colloid solution. Anesthesiol Clin (2011) 0.85
Production of a mouse line with a conditional Crim1 mutant allele. Genesis (2012) 0.82
Nitric oxide and promotion of cardiac myocyte apoptosis. Mol Cell Biochem (2004) 0.82
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
Structural determinants for phosphatidic acid regulation of phospholipase C-beta1. J Biol Chem (2006) 0.81
Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis. J Immunol (2010) 0.81
Computational method for estimating DNA copy numbers in normal samples, cancer cell lines, and solid tumors using array comparative genomic hybridization. J Biomed Biotechnol (2010) 0.79
Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5. Biochimie (2013) 0.79
Cdc14b: a new player in aging. Aging (Albany NY) (2011) 0.78
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. Proc Natl Acad Sci U S A (2014) 0.76
A phosphatase turns aggressive: the oncogenicity of Cdc14B. Cell Cycle (2011) 0.75
The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2. J Biol Chem (2013) 0.75
Spindle assembly checkpoint, aneuploidy and tumorigenesis. Cell Cycle (2009) 0.75
A hydrogen-insertion asymmetric supercapacitor. Chemistry (2012) 0.75
Comparative analysis on determinants of self-rated health among non-Hispanic White, Hispanic, and Asian American older adults. J Immigr Minor Health (2014) 0.75
Making a breakthrough in healthcare interoperability. Good Samaritan anticipates substantial revenue increase while containing integration costs. Health Manag Technol (2016) 0.75
Seminars in Cell & Developmental Biology. Anaphase promoting complex, control of mitosis, and beyond & micronutrient and mineral supply in developmental biology. Editorial. Semin Cell Dev Biol (2011) 0.75
Amiodarone supplants lidocaine in ACLS and CPR protocols. Anesthesiol Clin (2011) 0.75
[Expression of inducible nitric oxide synthase and macrophage in human placenta of pregnancy induced hypertension syndrome]. Zhonghua Fu Chan Ke Za Zhi (2002) 0.75