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R Docampo

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. J Med Chem 2001 2.26
2 Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion. J Exp Med 1994 1.64
3 Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei. Biochem J 1994 1.53
4 Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi. J Biol Chem 2001 1.51
5 Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem 2001 1.42
6 The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes. J Biol Chem 2001 1.41
7 Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi. Mol Biochem Parasitol 1981 1.41
8 Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs. J Biol Chem 1999 1.39
9 Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi. J Biol Chem 1998 1.38
10 Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. J Biol Chem 1991 1.32
11 Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium. Mol Biochem Parasitol 2003 1.32
12 Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes. Arch Biochem Biophys 1978 1.29
13 Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J 1992 1.26
14 In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi. J Biol Chem 1997 1.16
15 31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates. J Biol Chem 2000 1.15
16 Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch Biochem Biophys 1979 1.14
17 Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi. Mol Cell Biol 1998 1.14
18 Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem J 2000 1.14
19 Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes. Mol Cell Biol 1999 1.13
20 Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase. Biochem J 1999 1.13
21 Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. Antimicrob Agents Chemother 1997 1.13
22 Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase. J Biol Chem 1984 1.12
23 Free radical metabolism of antiparasitic agents. Fed Proc 1986 1.12
24 Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release. J Biol Chem 1992 1.11
25 A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation. J Biol Chem 2000 1.09
26 Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J Biol Chem 1993 1.08
27 Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi. Biochem J 1978 1.08
28 Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity. Biochem J 1995 1.07
29 Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs. FEBS Lett 2000 1.07
30 Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi. Comp Biochem Physiol C 1978 1.07
31 Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environ Health Perspect 1985 1.06
32 Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei. Biochem J 1996 1.05
33 A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine. Biochem J 1993 1.04
34 Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool. Mol Biochem Parasitol 1992 1.03
35 Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages. Mol Biochem Parasitol 1993 1.03
36 Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi. Biochem J 1980 1.03
37 Localization of peroxidase activity in Trypanosoma cruzi microbodies. Experientia 1976 1.03
38 Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes. J Biol Chem 1997 1.03
39 Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi. Rev Infect Dis 1984 1.02
40 Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria. Mol Biochem Parasitol 1992 1.02
41 Generation of free radicals induced by nifurtimox in mammalian tissues. J Biol Chem 1981 1.01
42 Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Science 1983 1.01
43 Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone. Exp Parasitol 1977 1.01
44 A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum. FEBS Lett 1999 1.01
45 Chemotherapy for Chagas' disease: a perspective of current therapy and considerations for future research. Rev Infect Dis 1987 1.00
46 In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. Ann Trop Med Parasitol 1978 1.00
47 Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi. Biochem Pharmacol 1981 1.00
48 Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi. J Med Chem 1998 0.98
49 Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria. J Biol Chem 2000 0.97
50 Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorg Med Chem Lett 2001 0.97
51 Characterization of isolated acidocalcisomes of Trypanosoma cruzi. J Biol Chem 2000 0.97
52 Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes. J Biol Chem 1983 0.97
53 Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations. Arch Biochem Biophys 1982 0.95
54 Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi. Biochem J 2000 0.95
55 The role of a H(+)-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes. Biochem J 1996 0.95
56 Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi. Biochem J 1998 0.94
57 Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi. Biochem J 1995 0.94
58 The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization. J Eukaryot Microbiol 2001 0.93
59 Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase. J Biol Chem 1984 0.93
60 Regulation of intracellular calcium homeostasis in Trypanosoma cruzi. Effects of calmidazolium and trifluoperazine. Cell Calcium 1991 0.93
61 Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes. J Biol Chem 1987 0.92
62 The fine structure of acidocalcisomes in Trypanosoma cruzi. Parasitol Res 2000 0.92
63 Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi. Acta Trop 1978 0.92
64 Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus. J Biol Chem 1983 0.92
65 Subcellular localization of phosphoenolpyruvate carboxykinase in the trypanosomatids Trypanosoma cruzi and Crithidia fasciculata. Mol Biochem Parasitol 1982 0.90
66 Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes. J Biol Chem 1984 0.90
67 Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective enzymes in Trypanosoma cruzi. Comp Biochem Physiol B 1982 0.89
68 Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes. Acta Trop 1978 0.89
69 A calmodulin-activated (Ca(2+)-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi. Biochem J 1991 0.89
70 Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria. Antimicrob Agents Chemother 1978 0.89
71 Ca2+ transport in digitonin-permeabilized trypanosomatids. Mol Biochem Parasitol 1990 0.89
72 Inhibition of Ca2+ release from Trypanosoma brucei acidocalcisomes by 3,5-dibutyl-4-hydroxytoluene: role of the Na+/H+ exchanger. Biochem J 1997 0.88
73 (31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth. Biochem Biophys Res Commun 2001 0.87
74 TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi. J Biol Chem 2001 0.87
75 Two types of H+-ATPase are involved in the acidification of internal compartments in Trypanosoma cruzi. Biochem J 1998 0.86
76 Calcium mobilization by arachidonic acid in trypanosomatids. Mol Biochem Parasitol 2000 0.85
77 A pyruvate-proton symport and an H+-ATPase regulate the intracellular pH of Trypanosoma brucei at different stages of its life cycle. Biochem J 2000 0.84
78 Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria. J Biol Chem 1988 0.84
79 Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation. J Med Chem 2000 0.84
80 Reduction of the metallochromic indicators arsenazo III and antipyrylazo III to their free radical metabolites by cytoplasmic enzymes. FEBS Lett 1985 0.84
81 Evaluation of the toxicity of 3-allyl-beta-lapachone against Trypanosoma cruzi bloodstream forms. Mol Biochem Parasitol 1980 0.83
82 Effect of inhibitors of electron transport and oxidative phosphorylation on Trypanosoma cruzi respiration and growth. Mol Biochem Parasitol 1980 0.83
83 beta-Lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by sarcoma 180 ascites tumor cells. Biochem Pharmacol 1979 0.83
84 The mitochondrion of Trypanosoma cruzi is a target of crystal violet toxicity. Mol Biochem Parasitol 1989 0.83
85 Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes). J Med Chem 1997 0.82
86 Trypanosoma cruzi: effect of olivacine on macromolecular synthesis, ultrastructure, and respiration of epimastigotes. Exp Parasitol 1978 0.80
87 Intracellular distribution of carbon dioxide-fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata. J Gen Microbiol 1980 0.80
88 Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives. Mol Biochem Parasitol 1996 0.80
89 Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes. Biochem J 1996 0.80
90 Ecto-protein tyrosine phosphatase activity in Trypanosoma cruzi infective stages. Mol Biochem Parasitol 1998 0.80
91 Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPases. Mol Biochem Parasitol 2000 0.79
92 [Effect of antimycin A on the respiration and growth of Trypanosoma cruzi]. Medicina (B Aires) 1980 0.79
93 Tricarboxylic acid cycle operation at the kinetoplast-mitochondrion complex of Trypanosoma cruzi. Biochim Biophys Acta 1978 0.79
94 Tyrosine phosphate hydrolysis of host proteins by Trypanosoma cruzi is linked to cell invasion. FEMS Microbiol Lett 1998 0.78
95 Mercaptopyridine-N-oxide, an NADH-fumarate reductase inhibitor, blocks Trypanosoma cruzi growth in culture and in infected myoblasts. FEMS Microbiol Lett 1999 0.77
96 Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi. Z Parasitenkd 1978 0.77
97 Metabolic requirements for the damage of Trypanosoma cruzi epimastigotes by human polymorphonuclear leukocytes. J Parasitol 1982 0.77
98 Regulation of the plasma membrane potential in Pneumocystis carinii. FEMS Microbiol Lett 2000 0.77
99 Inhibition of protein synthesis and amino acid transport by crystal violet in Trypanosoma cruzi. J Eukaryot Microbiol 1996 0.77
100 Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet. Mol Biochem Parasitol 1994 0.76
101 The photodynamic action of rose bengal on Trypanosoma cruzi. Acta Trop 1984 0.76
102 Analysis of the uptake of the fluorescent marker 2',7'-bis-(2-carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF) by hydrogenosomes in Trichomonas vaginalis. Eur J Cell Biol 1998 0.76
103 ATP and Ca2+ homeostasis in Trypanosoma cruzi. Braz J Med Biol Res 1993 0.75
104 Reduction of the metallochromic indicators murexide and tetramethylmurexide to their free radical metabolites by cytoplasmic enzymes and reducing agents. Chem Biol Interact 1986 0.75
105 On the mechanism of killing of Trypanosoma cruzi by human polymorphonuclear leukocytes. Experientia 1985 0.75
106 Synthetic trypanocides: growth-inhibiting properties of new 1,2,3,4-tetrahydrocarbazoles on Trypanosoma cruzi. Rev Argent Microbiol 1988 0.75
107 Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment. Biochem Pharmacol 1983 0.75
108 [Metabolic changes in diskinetoplastic Trypanosoma cruzi by ethidium bromide action]. Medicina (B Aires) 1975 0.75
109 [Intracellular distribution of CO2-fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata]. Medicina (B Aires) 1980 0.75
110 [Cytochromes in epimastigote form of Trypanosoma cruzi]. Rev Argent Microbiol 1980 0.75
111 Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation. Arch Biochem Biophys 1981 0.75
112 Drugs inducing generation of free radicals in Trypanosoma cruzi [proceedings]. An Acad Bras Cienc 1978 0.75
113 Oxygen-derived radicals from Trypanosoma cruzi-stimulated human neutrophils. FEBS Lett 1983 0.75
114 Evidence for free radical formation during horseradish peroxidase-catalyzed N-demethylation of crystal violet. Chem Biol Interact 1992 0.75
115 [Effect of beta and alpha-lapachone on the production of H202 and on the growth of Trypanosoma cruzi]. Rev Asoc Argent Microbiol 1978 0.75
116 [Stimulation of lipid peroxidation and ultrastructural changes induced by nifurtimox in mammalian tissue]. Medicina (B Aires) 1981 0.75
117 [Undesirable effects of benznidazole and nifurtimox]. Medicina (B Aires) 1983 0.75
118 The presence of basic proteins associated to the kinetoplast-DNA of Trypanosoma cruzi epimastigotes. Short communication. Acta Trop 1979 0.75
119 [Ultrastructure of Trypanosoma cruzi with scanning and transmission electromicroscopy]. Rev Asoc Argent Microbiol 1975 0.75
120 Acetate oxidation by bloodstream forms of Trypanosoma cruzi. J Protozool 1979 0.75
121 New and re-emerging diseases: a dedication to Norman D. Levine. Parasitol Today 2000 0.75
122 Reduction of 5-nitroimidazoles, nitrofurazone, and 2,4-dinitrophenol to their free radical metabolites by Tritrichomonas foetus hydrogenosomes. Basic Life Sci 1988 0.75
123 Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi. Bioorg Med Chem Lett 1998 0.75
124 [Mechanism of the trypanocidal action of nifurtimox and other nitro-derivatives on Trypanosoma cruzi]. Medicina (B Aires) 1980 0.75
125 Photosensitization by the trypanocidal agent crystal violet. Type I versus type II reactions. Chem Biol Interact 1986 0.75
126 [Metabolic differences in Trypanosoma cruzi depending of the culturing conditions]. Rev Asoc Argent Microbiol 1975 0.75
127 [Influence of nifurtimox on the glutathione content of the liver and bile in rats]. Medicina (B Aires) 1983 0.75
128 Sulphur-containing derivatives structurally related to fenoxycarb are potent growth inhibitors against the intracellular form of Trypanosoma cruzi. Int J Antimicrob Agents 2000 0.75