Published in PLoS One on March 15, 2011
Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet (2014) 1.62
Histone variants: emerging players in cancer biology. Cell Mol Life Sci (2013) 1.17
Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer. Breast Cancer Res (2012) 0.95
Genetics of breast cancer bone metastasis: a sequential multistep pattern. Clin Exp Metastasis (2014) 0.87
CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions. Cell Rep (2016) 0.82
Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells. Mol Cancer (2012) 0.81
SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin. Mol Biol Cell (2016) 0.80
Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation. PLoS One (2011) 0.80
CENP-A is essential for cardiac progenitor cell proliferation. Cell Cycle (2013) 0.78
A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint. J Biol Chem (2015) 0.77
Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance. PeerJ (2015) 0.76
Essential role for centromeric factors following p53 loss and oncogenic transformation. Genes Dev (2017) 0.75
Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. Dev Cell (2017) 0.75
Targeting mitotic pathways for endocrine-related cancer therapeutics. Endocr Relat Cancer (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72
Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer (2006) 10.05
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet (2002) 7.67
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov (2008) 4.03
CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell (2008) 3.68
The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat Cell Biol (2001) 3.59
Expanding small RNA interference. Nat Biotechnol (2002) 3.41
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution. Am J Hum Genet (2008) 2.88
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell (2007) 2.20
Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. Cancer Res (2003) 2.07
CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol (2005) 2.00
A solid foundation: functional specialization of centromeric chromatin. Curr Opin Genet Dev (2001) 1.88
Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One (2010) 1.84
Centromerization. Trends Cell Biol (2000) 1.77
Centromeres and variant histones: what, where, when and why? Curr Opin Cell Biol (2002) 1.76
Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Mol Biol Cell (2004) 1.73
p21--negative regulator of the cell cycle. Proc Soc Exp Biol Med (1996) 1.61
Centromere DNA dynamics: latent centromeres and neocentromere formation. Am J Hum Genet (1997) 1.61
p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell (2007) 1.54
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1. Biochem Biophys Res Commun (2001) 1.49
Dissection of CENP-C-directed centromere and kinetochore assembly. Mol Biol Cell (2009) 1.49
Recombination, rearrangement, reshuffling, and divergence in a centromeric region of rice. Proc Natl Acad Sci U S A (2005) 1.48
Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A (2009) 1.47
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Oncogene (2004) 1.43
DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet (2009) 1.41
Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res (2005) 1.40
Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology (2003) 1.38
CENPA overexpression promotes genome instability in pRb-depleted human cells. Mol Cancer (2009) 1.31
Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery. Oncogene (2001) 1.27
The CENP-A homolog CaCse4p in the pathogenic yeast Candida albicans is a centromere protein essential for chromosome transmission. Proc Natl Acad Sci U S A (2002) 1.26
Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res (2007) 1.13
CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Mol Cell Biol (2010) 1.11
Detection and identification of tumor-associated protein variants in human hepatocellular carcinomas. Hepatology (2004) 1.09
Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer (2010) 1.04
RNAi knockdown of human kinetochore protein CENP-H. Biochem Biophys Res Commun (2006) 1.04
CENP-F gene amplification and overexpression in head and neck squamous cell carcinomas. Head Neck (2001) 0.99
Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma. Mod Pathol (2006) 0.95
Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. Hepatology (2009) 0.94
Clinicopathologic significance of mitotic arrest defective protein 2 overexpression in hepatocellular carcinoma. Hum Pathol (2008) 0.92
Skp2: caught in the Akt. Nat Cell Biol (2009) 0.88
CenH3/CID incorporation is not dependent on the chromatin assembly factor CHD1 in Drosophila. PLoS One (2010) 0.87
Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. Electrophoresis (2001) 0.87
[Expression of centromere protein A in hepatocellular carcinoma]. Zhonghua Bing Li Xue Za Zhi (2007) 0.85
Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions. Oncogene (1999) 0.84
Frodos found: Behold the CENP-a "Ring" bearers. Cell (2009) 0.83
Neocentromeres come of age. PLoS Genet (2009) 0.78
[Effect of siRNA targeting centromere protein-A gene on biological behavior of HepG2 cells]. Zhonghua Bing Li Xue Za Zhi (2008) 0.76
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA (2009) 7.78
Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med (2006) 7.14
Survival after initial diagnosis of Alzheimer disease. Ann Intern Med (2004) 5.52
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08
Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA (2008) 4.06
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet (2005) 3.98
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A (2005) 3.72
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53
Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. Nat Biotechnol (2012) 3.52
Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog (2010) 3.44
Molecular electric transducers as motion sensors: a review. Sensors (Basel) (2013) 3.16
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res (2012) 2.74
Intrathoracic impedance monitoring in patients with heart failure: correlation with fluid status and feasibility of early warning preceding hospitalization. Circulation (2005) 2.66
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer. J Clin Oncol (2013) 2.44
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res (2008) 2.38
A comparative analysis of five methods of determining corneal refractive power in eyes that have undergone myopic laser in situ keratomileusis. Ophthalmology (2002) 2.37
Trends in stress urinary incontinence inpatient procedures in the United States, 1979-2004. Am J Obstet Gynecol (2009) 2.33
Multiobjective optimization design of a fractional order PID controller for a gun control system. ScientificWorldJournal (2013) 2.33
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33
Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood (2006) 2.29
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A (2006) 2.23
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med (2007) 2.17
Reversible and selective amine interactions of [Cd(mu2-N,O-p-NH2C6H4SO3)2(H2O)2]n. Dalton Trans (2004) 2.13
Microbiota of the seminal fluid from healthy and infertile men. Fertil Steril (2013) 2.10
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci (2013) 2.04
A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer. Biomaterials (2009) 2.04
Remodeling of organelle-bound actin is required for yeast vacuole fusion. J Cell Biol (2002) 1.92
Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitol Res (2012) 1.91
Episiotomy in the United States: has anything changed? Am J Obstet Gynecol (2009) 1.86
High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol Ther (2009) 1.86
Periodically Aligned Si Nanopillar Arrays as Efficient Antireflection Layers for Solar Cell Applications. Nanoscale Res Lett (2010) 1.85
Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin. J Invest Dermatol (2012) 1.84
Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (2008) 1.83
An integrative approach for causal gene identification and gene regulatory pathway inference. Bioinformatics (2006) 1.82
Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. Genome Res (2013) 1.78
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (2012) 1.77
Clinical predictors and outcomes of pars plana vitrectomy for retained lens material after cataract extraction. Am J Ophthalmol (2009) 1.73
MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem (2009) 1.73
TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol (2007) 1.72
Further understanding human disease genes by comparing with housekeeping genes and other genes. BMC Genomics (2006) 1.68
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology (2011) 1.67
Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11. J Clin Microbiol (2008) 1.67
LABEL: pediatric brain extraction using learning-based meta-algorithm. Neuroimage (2012) 1.66
Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta (2010) 1.66
Major abdominal surgery in nursing home residents: a national study. Ann Surg (2011) 1.64
Land suitability assessment on a watershed of Loess Plateau using the analytic hierarchy process. PLoS One (2013) 1.64
Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology (2008) 1.64
Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology (2015) 1.63
Crystal structure of group II chaperonin in the open state. Structure (2010) 1.62
Contribution of posterior corneal astigmatism to total corneal astigmatism. J Cataract Refract Surg (2012) 1.62
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem (2010) 1.61
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biol (2009) 1.61
A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet (2010) 1.60
Single-tube linear DNA amplification (LinDA) for robust ChIP-seq. Nat Methods (2011) 1.60
Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels. Cardiovasc Res (2003) 1.59
The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Mol Cell (2011) 1.59
microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59
Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. Blood (2007) 1.59
LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol (2003) 1.58
Rifaximin versus nonabsorbable disaccharides in the management of hepatic encephalopathy: a meta-analysis. Eur J Gastroenterol Hepatol (2008) 1.58
A low energy oxide-based electronic synaptic device for neuromorphic visual systems with tolerance to device variation. Adv Mater (2013) 1.57
MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res (2009) 1.55
Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer. J Clin Endocrinol Metab (2009) 1.55
CGI: a new approach for prioritizing genes by combining gene expression and protein-protein interaction data. Bioinformatics (2006) 1.55
Vaccination with selected synovial T cells in rheumatoid arthritis. Arthritis Rheum (2007) 1.53
Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol (2012) 1.53
Macroscopic serosal classification predicts peritoneal recurrence for patients with gastric cancer underwent potentially curative surgery. Ann Surg Oncol (2010) 1.52
TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer. J Clin Endocrinol Metab (2014) 1.52
Concern Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure. Stem Cell Res Ther (2013) 1.52
Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies. Heart (2011) 1.51
Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res (2008) 1.50
Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol (2010) 1.50
Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J Immunol (2009) 1.49
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res (2007) 1.48
Extreme mtDNA homogeneity in continental Asian populations. Am J Phys Anthropol (2002) 1.47
High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors. J Clin Endocrinol Metab (2007) 1.47
Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells. Leuk Res (2008) 1.47
A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation. Proc Natl Acad Sci U S A (2006) 1.47
Expression levels of Lyn, Syk, PLCγ2 and ERK in patients with chronic lymphocytic leukemia, and higher levels of Lyn are associated with a shorter treatment-free survival. Leuk Lymphoma (2012) 1.46
A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population. Hypertens Res (2011) 1.46
MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One (2013) 1.46
Genetic variants in 2q31 and 5p15 are associated with aggressive benign prostatic hyperplasia in a Chinese population. Prostate (2013) 1.45
Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma (2012) 1.45
Visualization of regulated exocytosis with a granule-membrane probe using total internal reflection microscopy. Mol Biol Cell (2004) 1.44
Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab (2010) 1.44
Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization. J Am Chem Soc (2008) 1.43
Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma. Crit Care Med (2014) 1.43
Trends in inpatient prolapse procedures in the United States, 1979-2006. Am J Obstet Gynecol (2010) 1.43
Prevalence and risk factors of urinary incontinence for post-stroke inpatients in Southern China. Neurourol Urodyn (2013) 1.42
Genomic analyses of recombinant adenovirus type 11a in China. J Clin Microbiol (2009) 1.41
Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer (2010) 1.40