Published in Cancer Prev Res (Phila) on April 13, 2011
Clonal evolution in cancer. Nature (2012) 11.07
A Big Bang model of human colorectal tumor growth. Nat Genet (2015) 3.77
Cancer evolution: mathematical models and computational inference. Syst Biol (2014) 1.36
Identification of neutral tumor evolution across cancer types. Nat Genet (2016) 1.25
TrAp: a tree approach for fingerprinting subclonal tumor composition. Nucleic Acids Res (2013) 1.23
Cancer in light of experimental evolution. Curr Biol (2012) 1.17
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. Sci Rep (2015) 1.02
Cancer across the tree of life: cooperation and cheating in multicellularity. Philos Trans R Soc Lond B Biol Sci (2015) 1.00
The mathematics of cancer: integrating quantitative models. Nat Rev Cancer (2015) 1.00
Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics. PLoS Comput Biol (2014) 0.98
Preventive evolutionary medicine of cancers. Evol Appl (2012) 0.91
Bioinformatics for cancer immunology and immunotherapy. Cancer Immunol Immunother (2012) 0.90
Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer (2012) 0.87
Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations. Evol Appl (2012) 0.87
Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl (2012) 0.84
Cancer heterogeneity: origins and implications for genetic association studies. Trends Genet (2012) 0.83
Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterology (2015) 0.81
Methods and challenges in timing chromosomal abnormalities within cancer samples. Bioinformatics (2013) 0.81
Toward a general evolutionary theory of oncogenesis. Evol Appl (2012) 0.81
Inferring the temporal order of cancer gene mutations in individual tumor samples. PLoS One (2014) 0.79
Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study. IEEE/ACM Trans Comput Biol Bioinform (2015) 0.77
Identifying restrictions in the order of accumulation of mutations during tumor progression: effects of passengers, evolutionary models, and sampling. BMC Bioinformatics (2015) 0.77
A population genetics perspective on the determinants of intra-tumor heterogeneity. Biochim Biophys Acta (2017) 0.76
Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models. Front Oncol (2015) 0.76
Inferring models of multiscale copy number evolution for single-tumor phylogenetics. Bioinformatics (2015) 0.76
FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe. PLoS One (2016) 0.75
The hallmarks of cancer. Cell (2000) 113.05
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics (1964) 45.28
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
The clonal evolution of tumor cell populations. Science (1976) 24.39
Cancer genes and the pathways they control. Nat Med (2004) 24.22
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43
Cancer as an evolutionary and ecological process. Nat Rev Cancer (2006) 9.33
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature (2011) 6.39
Inferring tumor progression from genomic heterogeneity. Genome Res (2009) 6.09
Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A (2010) 4.47
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest (2010) 4.22
Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res (1997) 4.02
Genetic progression and the waiting time to cancer. PLoS Comput Biol (2007) 3.57
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci U S A (2002) 3.57
Evolution of neoplastic cell lineages in Barrett oesophagus. Nat Genet (1999) 3.30
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. Gut (2008) 2.51
Inferring tree models for oncogenesis from comparative genome hybridization data. J Comput Biol (1999) 2.25
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science (1996) 2.22
Metapopulation dynamics and spatial heterogeneity in cancer. Proc Natl Acad Sci U S A (2002) 2.17
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology (2010) 1.83
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer. Proc Natl Acad Sci U S A (2010) 1.81
Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63
Beneficial mutations and the dynamics of adaptation in asexual populations. Philos Trans R Soc Lond B Biol Sci (2010) 1.60
Tracing the tumor lineage. Mol Oncol (2010) 1.56
Distance-based reconstruction of tree models for oncogenesis. J Comput Biol (2000) 1.55
Construction of evolutionary tree models for renal cell carcinoma from comparative genomic hybridization data. Cancer Res (2000) 1.45
Smoking molecular damage in bronchial epithelium. Oncogene (2002) 1.38
Quantifying cancer progression with conjunctive Bayesian networks. Bioinformatics (2009) 1.37
Karyotypic evolution in human malignant melanoma. Cancer Genet Cytogenet (1986) 1.34
An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications. J Pathol (2007) 1.32
Cell lineage analysis of a mouse tumor. Cancer Res (2008) 1.29
Simulating the hallmarks of cancer. Artif Life (2006) 1.25
Modeling somatic evolution in tumorigenesis. PLoS Comput Biol (2006) 1.22
Animal cell differentiation patterns suppress somatic evolution. PLoS Comput Biol (2007) 1.19
What are the hallmarks of cancer? Nat Rev Cancer (2010) 1.14
Evaluation of pathways for progression of heterogeneous breast tumors. J Theor Biol (2005) 1.09
Preinvasive breast cancer. Annu Rev Pathol (2010) 1.08
Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. Genes Chromosomes Cancer (2009) 1.03
Estimating an oncogenetic tree when false negatives and positives are present. Math Biosci (2002) 1.00
Inferring a tumor progression model for neuroblastoma from genomic data. J Clin Oncol (2005) 1.00
Evolution on distributive lattices. J Theor Biol (2006) 0.99
Construction of oncogenetic tree models reveals multiple pathways of oral cancer progression. Int J Cancer (2009) 0.97
Inferring progression models for CGH data. Bioinformatics (2009) 0.90
Deriving evolutionary tree models of the oncogenesis of endometrial adenocarcinoma. Int J Cancer (2007) 0.79
Clonal evolution in cancer. Nature (2012) 11.07
Cancer as an evolutionary and ecological process. Nat Rev Cancer (2006) 9.33
Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol (2007) 3.00
Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol (2011) 2.48
Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res (2006) 2.24
NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma. PLoS Med (2007) 2.23
A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev Res (Phila) (2010) 1.89
Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays (2014) 1.64
Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progression. Cancer Prev Res (Phila) (2008) 1.43
Population structure mediates sexual conflict in water striders. Science (2009) 1.41
Overlooking evolution: a systematic analysis of cancer relapse and therapeutic resistance research. PLoS One (2011) 1.32
Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus. Cancer Prev Res (Phila) (2013) 1.31
Animal cell differentiation patterns suppress somatic evolution. PLoS Comput Biol (2007) 1.19
Cancer in light of experimental evolution. Curr Biol (2012) 1.17
Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma. Clin Cancer Res (2009) 1.17
Life history trade-offs in cancer evolution. Nat Rev Cancer (2013) 1.16
Solving the puzzle of metastasis: the evolution of cell migration in neoplasms. PLoS One (2011) 1.12
Theory for the evolution of diffusible external goods. Evolution (2010) 1.07
The role of genetic diversity in cancer. J Clin Invest (2010) 1.05
Modelling the evolution of genetic instability during tumour progression. Evol Appl (2012) 1.04
The role of multilevel selection in the evolution of sexual conflict in the water strider aquarius remigis. Evolution (2010) 1.04
Spatial structure increases the waiting time for cancer. New J Phys (2011) 1.02
NSAIDs modulate clonal evolution in Barrett's esophagus. PLoS Genet (2013) 0.98
Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation. Cancer Epidemiol Biomarkers Prev (2006) 0.98
Preneoplastic lesion growth driven by the death of adjacent normal stem cells. Proc Natl Acad Sci U S A (2008) 0.97
New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management. Clin Cancer Res (2011) 0.96
NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biol Blood Marrow Transplant (2010) 0.95
Dispersal evolution in neoplasms: the role of disregulated metabolism in the evolution of cell motility. Cancer Prev Res (Phila) (2011) 0.91
Spontaneous Gac mutants of Pseudomonas biological control strains: cheaters or mutualists? Appl Environ Microbiol (2011) 0.90
Deletion at fragile sites is a common and early event in Barrett's esophagus. Mol Cancer Res (2010) 0.89
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. Cancer Epidemiol Biomarkers Prev (2006) 0.87
Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples. BMC Genomics (2008) 0.87
Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer (2012) 0.87
Neoplasia without dysplasia: lessons from Barrett esophagus and other tubal gut neoplasms. Arch Pathol Lab Med (2010) 0.84
An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition. BMC Cancer (2011) 0.83
How can evolutionary theory accommodate recent empirical results on organismal senescence? Theory Biosci (2007) 0.83
An evolutionary explanation for the presence of cancer nonstem cells in neoplasms. Evol Appl (2012) 0.82
New models of neoplastic progression in Barrett's oesophagus. Biochem Soc Trans (2010) 0.80
Development and characterization of an organotypic model of Barrett's esophagus. J Cell Physiol (2012) 0.80
Polyploidy, aneuploidy and the evolution of cancer. Adv Exp Med Biol (2010) 0.78
Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus. Am J Surg Pathol (2005) 0.78