An evolutionary analysis of trypanosomatid GP63 proteases.

Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23

Impact of Leishmania metalloprotease GP63 on macrophage signaling. Front Cell Infect Microbiol (2012) 0.98

Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix. J Parasitol Res (2012) 0.86

Genome evolution in trypanosomatid parasites. Parasitology (2014) 0.85

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evol Bioinform Online (2014) 0.83

Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms. Parasitol Res (2011) 0.78

Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients. PLoS Negl Trop Dis (2015) 0.78

PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci (1997) 45.07

Hidden Markov models in computational biology. Applications to protein modeling. J Mol Biol (1994) 31.57

The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48

Bayes empirical bayes inference of amino acid sites under positive selection. Mol Biol Evol (2005) 11.26

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res (2005) 10.60

The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64

The regulation of immunity to Leishmania major. Annu Rev Immunol (1995) 8.05

The new higher level classification of eukaryotes with emphasis on the taxonomy of protists. J Eukaryot Microbiol (2005) 7.94

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61

Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37

Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet (2007) 4.58

The promise of comparative genomics in mammals. Science (1999) 3.67

Kinetoplastids: related protozoan pathogens, different diseases. J Clin Invest (2008) 3.59

The timing of eukaryotic evolution: does a relaxed molecular clock reconcile proteins and fossils? Proc Natl Acad Sci U S A (2004) 3.33

Phylogenetic analysis using PHYLIP. Methods Mol Biol (2000) 3.27

Early evolution and the origin of eukaryotes. Curr Opin Genet Dev (1991) 3.12

The Trypanosoma cruzi proteome. Science (2005) 2.63

The real 'kingdoms' of eukaryotes. Curr Biol (2004) 2.26

Immunopathogenesis of infection with the visceralizing Leishmania species. Microb Pathog (2005) 2.19

Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease? Immunol Rev (2004) 2.12

The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function. Mol Biochem Parasitol (2003) 1.93

Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages. J Biol Chem (1989) 1.78

Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in himachal pradesh, India. Am J Trop Med Hyg (2005) 1.73

Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor. Mol Biochem Parasitol (2002) 1.65

Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism. Proc Natl Acad Sci U S A (1993) 1.62

Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat Rev Genet (2006) 1.47

Leishmania and Trypanosoma surface glycoproteins have a common glycophospholipid membrane anchor. Proc Natl Acad Sci U S A (1986) 1.36

The molecular evolution of Trypanosomatidae. Adv Parasitol (2001) 1.33

Mucosal leishmaniasis due to Leishmania (Viannia) panamensis in Colombia: clinical characteristics. Am J Trop Med Hyg (1998) 1.22

Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin Exp Immunol (1994) 1.16

Comparative genomics: from genotype to disease phenotype in the leishmaniases. Int J Parasitol (2007) 1.09

Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clin Exp Immunol (1994) 1.08

The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63). Structure (1998) 1.07

Expression and function of the Trypanosoma brucei major surface protease (GP63) genes. J Biol Chem (2003) 1.06

gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection. Infect Immun (2003) 1.04

The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains. BMC Genomics (2007) 1.03

A function for a specific zinc metalloprotease of African trypanosomes. PLoS Pathog (2007) 1.02

Major surface protease of trypanosomatids: one size fits all? Infect Immun (2009) 0.94

Long-term protection of mice against Leishmania major with a synthetic peptide vaccine. Vaccine (1999) 0.91

Complement interaction with trypanosomatid promastigotes in normal human serum. J Exp Med (2002) 0.90

African trypanosomes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease. J Biol Chem (1997) 0.89

Cutaneous leishmaniasis: progress towards a vaccine. Expert Rev Vaccines (2008) 0.87

The surface structure of trypanosomes in relation to their molecular phylogeny. Int J Parasitol (2001) 0.86

Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection. Infect Immun (2009) 0.86

Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes. Eukaryot Cell (2007) 0.85

Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania. Genetics (2000) 0.84

Differential expression of GP63 genes in Trypanosoma cruzi. Mol Biochem Parasitol (2000) 0.83

The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function. An Acad Bras Cienc (2006) 0.83

Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. Int J Oral Maxillofac Surg (2006) 0.79

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

International network of cancer genome projects. Nature (2010) 20.35

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Prepublication data sharing. Nature (2009) 12.24

The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67

A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24

Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science (2007) 4.89

VFDB: a reference database for bacterial virulence factors. Nucleic Acids Res (2005) 4.77

RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35

KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95

Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80

Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J Infect Dis (2004) 3.43

ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov (2011) 3.27

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe. Nat Genet (2012) 3.22

VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics. Nucleic Acids Res (2007) 3.07

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03

Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature (2004) 3.00

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96

Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95

Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation (2013) 2.95

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology (2012) 2.74

MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controls. Clin Cancer Res (2013) 2.71

BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69

PGAP: pan-genomes analysis pipeline. Bioinformatics (2011) 2.65

A new role for Nogo as a regulator of vascular remodeling. Nat Med (2004) 2.63

A complete sequence of the T. tengcongensis genome. Genome Res (2002) 2.60

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53

SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50

A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One (2007) 2.47

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis (2009) 2.45

MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther (2009) 2.41

Direct continuous method for monitoring biofilm infection in a mouse model. Infect Immun (2003) 2.35

Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics (2005) 2.34

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell (2011) 2.27

The analysis of large-scale gene expression correlated to the phase changes of the migratory locust. Proc Natl Acad Sci U S A (2004) 2.26

The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen. Nucleic Acids Res (2005) 2.21

Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. Genomics (2002) 2.16

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell (2003) 2.16

Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res (2006) 2.14

Vertebrate gene predictions and the problem of large genes. Nat Rev Genet (2003) 2.11

On the nature of human housekeeping genes. Trends Genet (2008) 2.06

T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model. Radiology (2011) 2.05

Compositional gradients in Gramineae genes. Genome Res (2002) 2.04

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med (2007) 2.04

High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer (2009) 2.03

Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell (2012) 2.02

The complete chloroplast genome sequence of date palm (Phoenix dactylifera L.). PLoS One (2010) 1.99

How many human genes can be defined as housekeeping with current expression data? BMC Genomics (2008) 1.97

Transcriptional adaptation of Shigella flexneri during infection of macrophages and epithelial cells: insights into the strategies of a cytosolic bacterial pathogen. Infect Immun (2005) 1.96

Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection. Infect Immun (2004) 1.95

alpha-Smooth Muscle Actin Expressing Stroma Promotes an Aggressive Tumor Biology in Pancreatic Ductal Adenocarcinoma. Pancreas (2010) 1.94

EvolView, an online tool for visualizing, annotating and managing phylogenetic trees. Nucleic Acids Res (2012) 1.90

Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology (2012) 1.87

A comparison of rice chloroplast genomes. Plant Physiol (2004) 1.85

KaKs_Calculator 2.0: a toolkit incorporating gamma-series methods and sliding window strategies. Genomics Proteomics Bioinformatics (2010) 1.85

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut (2010) 1.84

Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation. J Gastroenterol Hepatol (2012) 1.83

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Genes Dev (2014) 1.81

Effects of Helicobacter pylori eradication on methylation status of E-cadherin gene in noncancerous stomach. Clin Cancer Res (2006) 1.79

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A (2004) 1.75

ReAS: Recovery of ancestral sequences for transposable elements from the unassembled reads of a whole genome shotgun. PLoS Comput Biol (2005) 1.71

Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res (2011) 1.68

WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. Clin Cancer Res (2008) 1.67

A transcriptomic analysis of superhybrid rice LYP9 and its parents. Proc Natl Acad Sci U S A (2009) 1.67

Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer. Gut (2012) 1.67

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS One (2013) 1.65

Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci U S A (2005) 1.64

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep (2012) 1.63

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol (2013) 1.62

Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A (2005) 1.62

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res (2007) 1.62

The rice mitochondrial genomes and their variations. Plant Physiol (2005) 1.59

EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis. Cancer Res (2011) 1.58

Origin and evolution of new exons in rodents. Genome Res (2005) 1.57

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56

A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics (2009) 1.56

Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection. Antimicrob Agents Chemother (2003) 1.56

Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics. FEMS Microbiol Rev (2007) 1.55

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55

Evolution of alternative splicing after gene duplication. Genome Res (2005) 1.55

Revisiting the molecular evolutionary history of Shigella spp. J Mol Evol (2006) 1.54

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature (2012) 1.54

Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphylococcus aureus endocarditis model. Antimicrob Agents Chemother (2005) 1.54