Published in EMBO J on January 01, 1990
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med (1991) 10.87
Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol (1992) 3.10
Stepwise activation of the immunoglobulin mu heavy chain gene locus. EMBO J (2001) 2.14
Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J (1992) 2.12
PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol (1993) 2.08
A dominant-negative transgene defines a role for p56lck in thymopoiesis. EMBO J (1993) 1.98
V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J (1993) 1.97
Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A (2005) 1.85
Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Mol Cell Biol (1991) 1.80
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J (1993) 1.80
V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites. J Exp Med (2002) 1.56
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A (1996) 1.55
A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol (1993) 1.54
Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci U S A (1996) 1.51
Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. Mol Cell Biol (1991) 1.50
Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. EMBO J (1993) 1.44
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci U S A (1999) 1.44
TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J (1993) 1.39
Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol Cell Biol (1998) 1.38
Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. Proc Natl Acad Sci U S A (2002) 1.37
Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes. J Exp Med (1993) 1.36
Positive and negative regulation of V(D)J recombination by the E2A proteins. J Exp Med (1999) 1.36
Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain. Proc Natl Acad Sci U S A (1991) 1.36
Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J (1993) 1.34
Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system. Am J Pathol (1998) 1.31
Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers. J Exp Med (1994) 1.26
Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. J Exp Med (1994) 1.26
Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol (1999) 1.21
Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation. Mol Cell Biol (1991) 1.20
Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J Exp Med (1994) 1.19
Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol Cell Biol (1993) 1.18
Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.16
Enhancer control of local accessibility to V(D)J recombinase. Mol Cell Biol (1997) 1.12
The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol Cell Biol (1995) 1.09
Regulation of V(D)J recombination by transcriptional promoters. Mol Cell Biol (1999) 1.06
Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication. Proc Natl Acad Sci U S A (1993) 1.06
Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. Proc Natl Acad Sci U S A (2000) 1.04
A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J (1992) 1.00
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A (2003) 0.99
p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene. Proc Natl Acad Sci U S A (1993) 0.98
Regulation of T cell receptor delta gene rearrangement by c-Myb. J Exp Med (1996) 0.96
Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping. Mol Cell Biol (2000) 0.95
Unifying model for molecular determinants of the preselection Vβ repertoire. Proc Natl Acad Sci U S A (2013) 0.95
A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res (1992) 0.93
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors. Mol Cell Biol (1992) 0.93
Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunol Res (2011) 0.91
Epigenetic control of recombination in the immune system. Semin Immunol (2010) 0.91
Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer. Mol Cell Biol (1993) 0.91
Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate. Nucleic Acids Res (1994) 0.90
Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching. J Biol Chem (2011) 0.89
Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. J Exp Med (1997) 0.87
Binding of thymic factors to the conserved decanucleotide promoter element of the T-cell receptor V beta gene is developmentally regulated and is absent in SCID mice. Proc Natl Acad Sci U S A (1991) 0.86
Initiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assembly. PLoS One (2009) 0.85
Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage. Proc Natl Acad Sci U S A (1998) 0.85
A novel POU domain protein which binds to the T-cell receptor beta enhancer. Mol Cell Biol (1993) 0.85
Biased T-cell receptor delta element recombination in scid thymocytes. Mol Cell Biol (1993) 0.83
Domains of the TCR beta-chain required for early thymocyte development. J Exp Med (1996) 0.83
Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'. Immunology (2013) 0.82
Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor. Mol Cell Biol (1994) 0.81
Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element. Mol Cell Biol (1991) 0.81
The V(D)J recombination signal sequence and kappa B binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands. Nucleic Acids Res (1994) 0.80
A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Mol Cell Biol (1995) 0.80
Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” rule. Mol Cell Biol (2014) 0.80
Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation. J Immunol (2008) 0.78
Analyzing the CDR3 Repertoire with respect to TCR-Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS. Sci Rep (2016) 0.75
A dominant transcriptional silencer located 5' to the human T-cell receptor V beta 2.2 gene segment which is activated in cell lines of thymic phenotype. Nucleic Acids Res (1996) 0.75
From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. Eur J Immunol (2007) 0.75
Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ. J Clin Invest (1992) 0.75
Somatic generation of antibody diversity. Nature (1983) 28.06
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell (1983) 18.86
"Panning" for lymphocytes: a method for cell selection. Proc Natl Acad Sci U S A (1978) 17.69
T-cell antigen receptor genes and T-cell recognition. Nature (1988) 16.77
Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell (1986) 15.30
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature (1980) 10.19
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J (1983) 10.00
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science (1985) 9.73
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science (1987) 7.63
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol Rev (1982) 6.43
Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell (1981) 6.31
The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol (1986) 6.23
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. Nature (1984) 6.05
The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucleic Acids Res (1982) 5.66
A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med (1976) 5.13
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J (1987) 4.58
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature (1981) 4.26
Development of the primary antibody repertoire. Science (1987) 4.19
Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes. Nature (1984) 4.15
Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell (1989) 4.10
The T cell receptor. Science (1987) 4.00
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription. Cell (1987) 3.72
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
Developmental stage specificity of the lymphoid V(D)J recombination activity. Genes Dev (1987) 3.65
Differential expression of myc family genes during murine development. Nature (1986) 3.57
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell (1988) 3.34
Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell (1984) 3.24
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature (1982) 3.05
Chromatin changes accompany immunoglobulin kappa gene activation: a potential control region within the gene. Nature (1982) 2.98
C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon. Nature (1986) 2.94
Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element. EMBO J (1988) 2.93
Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer. Nature (1986) 2.86
Introduction of a rabbit beta-globin gene into the mouse germ line. Nature (1981) 2.82
Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus. Science (1983) 2.75
A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus. EMBO J (1989) 2.64
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell (1985) 2.59
Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines. Proc Natl Acad Sci U S A (1980) 2.57
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J (1989) 2.48
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity. Proc Natl Acad Sci U S A (1981) 2.38
Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell (1985) 2.36
Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature (1986) 2.33
The developmental biology of T lymphocytes. Annu Rev Immunol (1988) 2.27
Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell (1988) 2.14
T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining. Cell (1987) 2.07
The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts. EMBO J (1986) 1.95
A transcriptional enhancer 3' of C beta 2 in the T cell receptor beta locus. Science (1988) 1.91
Experimental models for understanding B lymphocyte formation. Adv Immunol (1987) 1.84
Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Mol Cell Biol (1986) 1.83
Identification and characterization of two functional domains within the murine heavy-chain enhancer. Mol Cell Biol (1988) 1.81
Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J Exp Med (1986) 1.72
An immunoglobulin heavy-chain gene is altered in two T-cell clones. Nature (1980) 1.60
During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Cell (1986) 1.59
The NF-kappa B-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells. Mol Cell Biol (1988) 1.54
Complex protein binding within the mouse immunoglobulin heavy-chain enhancer. Mol Cell Biol (1987) 1.48
A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Cell (1987) 1.42
In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer. Nucleic Acids Res (1988) 1.39
Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation. J Immunol (1984) 1.33
Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation. Nucleic Acids Res (1988) 1.26
T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. Int Immunol (1989) 1.13
Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice. Proc Natl Acad Sci U S A (1987) 1.13
Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice. Nature (1987) 1.11
Thymocyte subsets transformed by Abelson murine leukemia virus. Mol Cell Biol (1985) 1.03
Lineage-specific expression of a T cell receptor variable gene promoter controlled by upstream sequences. J Exp Med (1989) 0.98
Two classes of mouse mast cells delineated by monoclonal antibodies. Proc Natl Acad Sci U S A (1983) 0.92
T cell receptor beta gene has two downstream DNase I hypersensitive regions. Possible mechanisms of tissue- and stage-specific gene regulation. J Exp Med (1989) 0.90
Rearrangement of exogenous immunoglobulin VH and DJH gene segments after retroviral transduction into immature lymphoid cell lines. J Exp Med (1988) 0.84
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56
A common language for physical mapping of the human genome. Science (1989) 17.36
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
A physical map of the human genome. Nature (2001) 12.39
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
The myoD gene family: nodal point during specification of the muscle cell lineage. Science (1991) 9.53
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem (1978) 9.13
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79
A ligase-mediated gene detection technique. Science (1988) 7.61
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87
The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature (1994) 5.61
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature (1998) 4.97
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature (1986) 4.95
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (2000) 4.75
Impairment of V(D)J recombination in double-strand break repair mutants. Science (1993) 4.72
Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
A new strategy for genome sequencing. Nature (1996) 4.61
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature (1990) 4.53
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature (1998) 4.37
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell (1996) 4.35
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell (1995) 4.35
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25
Defective B cell development and function in Btk-deficient mice. Immunity (1995) 4.20
Development of the primary antibody repertoire. Science (1987) 4.19
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (1984) 4.18
Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell (1983) 4.13
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A (1997) 4.13
Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol (1986) 4.09
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99
Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature (1999) 3.86
Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J (1988) 3.82
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell (1990) 3.70
Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol (1993) 3.67
Ku80 is required for immunoglobulin isotype switching. EMBO J (1998) 3.67
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65
Developmental regulation of a cloned adult beta-globin gene in transgenic mice. Nature (1985) 3.63
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev (2000) 3.62
Silkmoth chorion proteins: sequence analysis of the products of a multigene family. Proc Natl Acad Sci U S A (1978) 3.60
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity (1998) 3.58
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell (1996) 3.55
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
CTLA-4-Mediated inhibition of early events of T cell proliferation. J Immunol (1999) 3.49
Large-scale and automated DNA sequence determination. Science (1991) 3.45
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature (1986) 3.40
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med (1998) 3.37
The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments. Nature (1985) 3.36
Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity (1997) 3.35
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity (1997) 3.33
Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell (1984) 3.24