Published in Cell on January 31, 1986
Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin. J Virol (1986) 3.21
Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element. EMBO J (1988) 2.93
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J (1986) 2.62
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J (1990) 2.52
Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol Cell Biol (1987) 2.33
Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J (1987) 2.31
Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J (1992) 2.12
Ly1+ PRO-B lymphocyte clones. Phenotype, growth requirements and differentiation in vitro and in vivo. EMBO J (1987) 2.00
VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. EMBO J (1986) 1.99
Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc Natl Acad Sci U S A (1988) 1.95
CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J (1992) 1.94
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J (1989) 1.86
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J (1993) 1.80
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains. J Exp Med (1988) 1.78
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol (2008) 1.70
The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells. J Exp Med (1991) 1.68
A conserved sequence in the T-cell receptor beta-chain promoter region. Proc Natl Acad Sci U S A (1988) 1.64
A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol (1993) 1.54
Junctional sequences of fetal T cell receptor beta chains have few N regions. J Exp Med (1991) 1.54
Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci U S A (1996) 1.51
Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Mol Cell Biol (1990) 1.50
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment. Nucleic Acids Res (1989) 1.48
Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins. Mol Cell Biol (1990) 1.47
Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny. Proc Natl Acad Sci U S A (1992) 1.44
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model. EMBO J (1990) 1.44
Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements. Mol Cell Biol (1990) 1.42
Genomic organization of the human T-cell antigen-receptor alpha/delta locus. Proc Natl Acad Sci U S A (1988) 1.41
Continuing rearrangement of immunoglobulin and T-cell receptor genes in a Ha-ras-transformed lymphoid progenitor cell line. Proc Natl Acad Sci U S A (1987) 1.37
Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol (1991) 1.37
Positive and negative regulation of V(D)J recombination by the E2A proteins. J Exp Med (1999) 1.36
Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro. Proc Natl Acad Sci U S A (1988) 1.36
Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J (1993) 1.34
Human T cell gamma genes are frequently rearranged in B-lineage acute lymphoblastic leukemias but not in chronic B cell proliferations. J Exp Med (1987) 1.28
Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. J Exp Med (2004) 1.27
Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. J Exp Med (1994) 1.26
Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation. Mol Cell Biol (1991) 1.20
Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion. J Exp Med (1998) 1.19
Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells. EMBO J (1987) 1.19
Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol Cell Biol (1993) 1.18
Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J Exp Med (1988) 1.16
Transcription from a murine T-cell receptor V beta promoter depends on a conserved decamer motif similar to the cyclic AMP response element. Mol Cell Biol (1989) 1.16
High-frequency homologous recombination between duplicate chromosomal immunoglobulin mu heavy-chain constant regions. Mol Cell Biol (1989) 1.14
Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice. Proc Natl Acad Sci U S A (1987) 1.13
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction. J Immunol (2009) 1.13
Rearrangement of immunoglobulin heavy chain genes in human T leukaemic cells shows preferential utilization of the D segment (DQ52) nearest to the J region. EMBO J (1986) 1.12
High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line. Proc Natl Acad Sci U S A (1987) 1.11
Consistent breakage between consensus recombinase heptamers of chromosome 9 DNA in a recurrent chromosomal translocation of human T cell leukemia. J Exp Med (1989) 1.11
Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. Biochim Biophys Acta (2009) 1.10
Expression of T cell receptor genes in human B cells. J Exp Med (1986) 1.10
The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol Cell Biol (1995) 1.09
Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia. Am J Pathol (1989) 1.09
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A (2010) 1.08
T-cell receptor and immunoglobulin genes are rearranged together in Abelson virus-transformed pre-B and pre-T cells. Mol Cell Biol (1987) 1.07
A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Mol Cell Biol (1990) 1.03
Differential regulation of the N-myc gene in transfected cells and transgenic mice. Mol Cell Biol (1990) 1.02
Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development. Proc Natl Acad Sci U S A (1990) 1.02
Identification of a DNA binding protein that recognizes the nonamer recombinational signal sequence of immunoglobulin genes. Proc Natl Acad Sci U S A (1987) 1.01
High frequency of clonal immunoglobulin or T cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxyribonucleotidyltransferase. J Exp Med (1987) 1.00
Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol Cell Biol (1989) 1.00
Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Proc Natl Acad Sci U S A (1986) 0.99
Transcriptional down-regulation of N-myc expression during B-cell development. Mol Cell Biol (1992) 0.98
Lineage-specific expression of a T cell receptor variable gene promoter controlled by upstream sequences. J Exp Med (1989) 0.98
V(D)J recombination is not activated by demethylation of the kappa locus. Proc Natl Acad Sci U S A (2000) 0.97
Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy. Am J Pathol (1988) 0.97
Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription. Mol Cell (2008) 0.95
B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment. Proc Natl Acad Sci U S A (1987) 0.95
Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk. Semin Immunol (2010) 0.95
Cell lineage specificity of chromatin configuration around the immunoglobulin heavy chain enhancer. EMBO J (1988) 0.95
A human cellular sequence implicated in trk oncogene activation is DNA damage inducible. Proc Natl Acad Sci U S A (1990) 0.95
Severe combined immunodeficiency (SCID) in man: B cell-negative (B-) SCID patients exhibit an irregular recombination pattern at the JH locus. J Exp Med (1991) 0.95
Immunoglobulin kappa light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement. Nucleic Acids Res (1989) 0.94
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors. Mol Cell Biol (1992) 0.93
Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT. J Virol (1989) 0.92
Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-kappaB-dependent and -independent pathways of activation. Mol Cell Biol (1997) 0.91
Premature termination of variable gene rearrangement in B lymphocytes from X-linked agammaglobulinemia. J Clin Invest (1988) 0.91
Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement. Mol Cell Biol (1992) 0.91
Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate. Nucleic Acids Res (1994) 0.90
Identification of a functional NF-kappa B binding site in the murine T cell receptor beta 2 locus. J Exp Med (1989) 0.89
Antigen receptor genes as molecular markers of lymphoid neoplasms. J Clin Invest (1987) 0.88
mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end. Nucleic Acids Res (1991) 0.87
Clonal diversity in the B cell repertoire of patients with X-linked agammaglobulinemia. J Exp Med (1989) 0.87
Graffi murine leukemia virus: molecular cloning and characterization of the myeloid leukemia-inducing agent. J Virol (1993) 0.86
Binding of thymic factors to the conserved decanucleotide promoter element of the T-cell receptor V beta gene is developmentally regulated and is absent in SCID mice. Proc Natl Acad Sci U S A (1991) 0.86
Initiator role of double stranded DNA in terminal transferase catalyzed polymerization reactions. Nucleic Acids Res (1988) 0.86
Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells. Immunology (2005) 0.85
DNase I sensitivity of immunoglobulin light chain genes in Abelson murine leukemia virus transformed pre-B cell lines. Nucleic Acids Res (1989) 0.85
A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors. Proc Natl Acad Sci U S A (1998) 0.85
Rearrangement of exogenous immunoglobulin VH and DJH gene segments after retroviral transduction into immature lymphoid cell lines. J Exp Med (1988) 0.84
Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia. J Exp Med (1987) 0.84
Transcription of unrearranged antigen receptor genes in scid mice. EMBO J (1988) 0.84
Novel B-cell precursors blocked at the stage of DJH recombination. Mol Cell Biol (1988) 0.84
A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods. J Immunol (2012) 0.83
T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia. J Clin Invest (1987) 0.83
VH replacement in primary immunoglobulin repertoire diversification. Proc Natl Acad Sci U S A (2015) 0.83
Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'. Immunology (2013) 0.82
The V(D)J recombination signal sequence and kappa B binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands. Nucleic Acids Res (1994) 0.80
GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer. Mol Cell Biol (1994) 0.80
Pyrophosphorolytic dismutation of oligodeoxy-nucleotides by terminal deoxynucleotidyltransferase. Nucleic Acids Res (1999) 0.80
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A common language for physical mapping of the human genome. Science (1989) 17.36
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (2001) 12.98
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
A physical map of the human genome. Nature (2001) 12.39
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol (2001) 10.85
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
The myoD gene family: nodal point during specification of the muscle cell lineage. Science (1991) 9.53
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science (1999) 9.18
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem (1978) 9.13
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell (1996) 9.10
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79
A ligase-mediated gene detection technique. Science (1988) 7.61
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol (2001) 6.71
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87
The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature (1986) 4.95
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (2000) 4.75
Impairment of V(D)J recombination in double-strand break repair mutants. Science (1993) 4.72
Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63
A new strategy for genome sequencing. Nature (1996) 4.61
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature (1998) 4.37
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell (1996) 4.35
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell (1995) 4.35
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science (1997) 4.26
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25
Defective B cell development and function in Btk-deficient mice. Immunity (1995) 4.20
Development of the primary antibody repertoire. Science (1987) 4.19
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (1984) 4.18
Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell (1983) 4.13
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A (1997) 4.13
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science (1999) 4.10
Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol (1986) 4.09
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99
Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature (1999) 3.86
Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J (1988) 3.82
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell (1996) 3.81
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol (1993) 3.67
Ku80 is required for immunoglobulin isotype switching. EMBO J (1998) 3.67
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev (2000) 3.62