Published in Blood on May 04, 2011
Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model. J Exp Med (2014) 1.59
Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis. Ann Rheum Dis (2014) 1.48
Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood (2014) 1.45
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
Sex differences in immune responses. Nat Rev Immunol (2016) 1.29
Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J Immunol (2014) 1.24
Gender differences in autoimmunity associated with exposure to environmental factors. J Autoimmun (2011) 1.11
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A (2013) 1.10
A molecular mechanism for TNF-α-mediated downregulation of B cell responses. J Immunol (2011) 1.10
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A (2013) 1.08
Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice. J Immunol (2012) 1.03
Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond. BMC Immunol (2012) 1.01
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. Blood (2012) 0.99
T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol (2013) 0.99
In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors. Aging Cell (2013) 0.97
Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med (2012) 0.96
An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity. Aging Cell (2013) 0.95
Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol (2013) 0.95
Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity. J Immunol (2015) 0.93
TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res (2013) 0.92
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep (2014) 0.92
Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A (2012) 0.91
Intra-abdominal fat depots represent distinct immunomodulatory microenvironments: a murine model. PLoS One (2013) 0.90
A comparative review of aging and B cell function in mice and humans. Curr Opin Immunol (2013) 0.90
Sexual dimorphism in autoimmunity. J Clin Invest (2015) 0.87
CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J Immunol (2015) 0.87
Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation. Biorheology (2015) 0.87
SLE in 2011: Deciphering the role of NETs and networks in SLE. Nat Rev Rheumatol (2012) 0.87
Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues. Aging Dis (2011) 0.84
Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice. Int Immunol (2014) 0.84
Hepatitis C viremia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B-cells. J Viral Hepat (2016) 0.84
Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight (2016) 0.84
B cells expressing the transcription factor T-bet drive lupus-like autoimmunity. J Clin Invest (2017) 0.83
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching. Aging Cell (2014) 0.82
T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response. JCI Insight (2017) 0.82
Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells. J Immunol (2016) 0.81
TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice. PLoS One (2012) 0.81
Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women? Expert Rev Clin Immunol (2012) 0.81
Aging and neoteny in the B lineage. Blood (2012) 0.81
Fate mapping of dendritic cells. Front Immunol (2015) 0.81
Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity (2016) 0.81
Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells. J Immunol (2012) 0.80
Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood (2014) 0.80
TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity. Cell Immunol (2014) 0.80
Immunosenescence, aging, and systemic lupus erythematous. Autoimmune Dis (2013) 0.80
Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels. J Immunol (2015) 0.80
Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis. J Clin Cell Immunol (2014) 0.79
Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma. Front Immunol (2014) 0.79
Impaired B lymphopoiesis in old age: a role for inflammatory B cells? Immunol Res (2013) 0.79
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. J Neuroinflammation (2014) 0.78
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells. J Immunol (2016) 0.78
Efficient B cell depletion via diphtheria toxin in CD19-Cre/iDTR mice. PLoS One (2013) 0.78
Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses. PLoS One (2012) 0.78
The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus. Clin Immunol (2014) 0.78
Immunological and nutritional factors in elderly people in low-level care and their association with mortality. Immun Ageing (2013) 0.77
Persistence of a large population of exhausted monoclonal B cells in mixed cryoglobuliemia after the eradication of hepatitis C virus infection. J Clin Immunol (2012) 0.77
Aged B cells alter immune regulation of allografts in mice. Eur J Immunol (2016) 0.76
Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLoS Pathog (2016) 0.76
Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging. Curr Aging Sci (2015) 0.76
αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells. Invest Ophthalmol Vis Sci (2012) 0.76
Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity. Front Immunol (2015) 0.76
Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation. J Immunol (2017) 0.76
IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism. J Immunol (2016) 0.76
Nodal marginal zone B cells in mice: a novel subset with dormant self-reactivity. Sci Rep (2016) 0.76
CD21(-/low) B cells in human blood are memory cells. Clin Exp Immunol (2016) 0.75
T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses. PLoS One (2016) 0.75
Prevalence of anti-citrullinated protein antibodies (ACPA) in patients with diffuse large B-cell lymphoma (DLBCL): a case-control study. PLoS One (2014) 0.75
Circulating monocytes and B-lymphocytes in neovascular age-related macular degeneration. Clin Ophthalmol (2017) 0.75
Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis. Biochim Biophys Acta (2016) 0.75
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest (2017) 0.75
Ageing adversely affects the migration and function of marginal zone B cells. Immunology (2017) 0.75
Immunosenescence in renal transplantation: a changing balance of innate and adaptive immunity. Curr Opin Organ Transplant (2015) 0.75
Now you know your ABCs. Blood (2011) 0.75
T-bet(+)CD11c(+) B cells are critical for antichromatin immunoglobulin G production in the development of lupus. Arthritis Res Ther (2017) 0.75
Obesity induces pro-inflammatory B cells and impairs B cell function in old mice. Mech Ageing Dev (2017) 0.75
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. Cell Death Dis (2017) 0.75
Early derivation of IgM memory cells and bone marrow plasmablasts. PLoS One (2017) 0.75
Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature (1961) 23.98
X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature (2005) 12.06
Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature (2001) 6.31
Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med (1979) 5.58
Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett (2003) 5.27
Sex differences in autoimmune disease. Nat Immunol (2001) 5.08
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med (2002) 3.83
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Blood (2010) 3.52
Sex ratio in the spondyloarthropathies and its relationship to phenotypic expression, mode of inheritance and age at onset. J Rheumatol (1993) 3.39
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol (2007) 3.17
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity (2006) 2.36
Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest (1977) 2.33
Discriminating gene expression profiles of memory B cell subpopulations. J Exp Med (2008) 2.00
A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med (2008) 1.96
Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci U S A (2009) 1.91
TLR7 ligands induce higher IFN-alpha production in females. J Immunol (2006) 1.88
A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol (2004) 1.86
Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol (2005) 1.75
Age and sex associations of 40 autoimmune diseases. Am J Med (1994) 1.69
Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia. Immunobiology (2002) 1.51
Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J Immunol (2006) 1.41
Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol (2002) 1.39
Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice. Genes Immun (2007) 1.39
Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patients. Mayo Clin Proc (2008) 1.30
TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol (2008) 1.29
CD11c expression identifies a population of extrafollicular antigen-specific splenic plasmablasts responsible for CD4 T-independent antibody responses during intracellular bacterial infection. J Immunol (2008) 1.19
A cross-species comparison of X-chromosome inactivation in Eutheria. Genomics (2007) 1.11
Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes. J Autoimmun (2009) 1.10
Genetics of systemic autoimmunity in mouse models of lupus. Int Rev Immunol (2000) 1.09
EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. J Immunol (2006) 1.07
The Yaa gene model of systemic lupus erythematosus. Immunol Rev (1995) 1.03
Identification of candidate genes that influence sex hormone-dependent disease phenotypes in mouse lupus. Genes Immun (2007) 0.97
Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. Int Immunol (2000) 0.94
Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis. Cytometry B Clin Cytom (2008) 0.92
Interferon production by lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum (1974) 0.89
Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3. Lupus (2009) 0.85
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood (2004) 3.19
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Rheumatoid arthritis-interstitial lung disease-associated mortality. Am J Respir Crit Care Med (2010) 3.05
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
Mycophenolate mofetil improves lung function in connective tissue disease-associated interstitial lung disease. J Rheumatol (2013) 2.74
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol (2006) 2.57
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A (2002) 2.44
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature (2009) 2.43
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol (2003) 2.09
How do adjuvants work? Important considerations for new generation adjuvants. Immunity (2007) 2.01
A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity (2011) 1.94
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A (2010) 1.87
Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol (2002) 1.85
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity (2009) 1.85
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol (2005) 1.77
Unique characteristics of systemic sclerosis sine scleroderma-associated interstitial lung disease. Chest (2006) 1.76
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity (2006) 1.71
Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS): baseline characteristics and description of study population. J Rheumatol (2011) 1.71
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol (2003) 1.69
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A (2011) 1.68
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol (2011) 1.54
Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol (2007) 1.49
Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease. Chest (2006) 1.48
Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A (2010) 1.47
CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol (2011) 1.43
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol (2004) 1.40
Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37
T cell apoptosis and reactive oxygen species. J Clin Invest (2003) 1.35
Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev (2006) 1.33
Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA. Clin Rheumatol (2009) 1.32
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest (2007) 1.32
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process. Immunity (2002) 1.26
Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A (2008) 1.25
Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev (2010) 1.24
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A (2004) 1.23
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol (2012) 1.22
Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.18
Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev (2005) 1.17
Alternate interactions define the binding of peptides to the MHC molecule IA(b). Proc Natl Acad Sci U S A (2002) 1.16
Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16
Memory CD4 T cells: generation, reactivation and re-assignment. Immunology (2010) 1.16
Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A (2008) 1.16
Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum (2005) 1.14
T cells and their eons-old obsession with MHC. Immunol Rev (2012) 1.13
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood (2010) 1.12
Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol (2007) 1.12
Not all CD4+ memory T cells are long lived. Immunol Rev (2006) 1.11
Tumor necrosis factor-alpha at the intersection of mycobacterial immunity and pathogenesis: an important new address in medicine. Clin Infect Dis (2008) 1.09