Published in Proc Natl Acad Sci U S A on August 26, 2008
Diversity in T cell memory: an embarrassment of riches. Immunity (2009) 3.31
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A (2009) 2.56
Immunosenescence: what does it mean to health outcomes in older adults? Curr Opin Immunol (2009) 2.09
Effects of aging on T cell function. Curr Opin Immunol (2009) 1.67
Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. J Leukoc Biol (2013) 1.58
Causes, consequences, and reversal of immune system aging. J Clin Invest (2013) 1.50
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol (2010) 1.41
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J Immunol (2012) 1.25
TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest (2011) 1.13
Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol (2010) 1.08
The narrowing of the CD8 T cell repertoire in old age. Curr Opin Immunol (2011) 1.04
Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J Immunol (2013) 0.92
CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model. J Alzheimers Dis (2010) 0.89
Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses. Exp Gerontol (2013) 0.86
Characterization of age-associated exhausted CD8(+) T cells defined by increased expression of Tim-3 and PD-1. Aging Cell (2016) 0.82
Kidney transplantation and the ageing immune system. Nat Rev Nephrol (2012) 0.76
Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature (1988) 11.55
Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol (2002) 9.45
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature (2003) 7.56
T cell anergy. Annu Rev Immunol (2001) 7.15
Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol (2003) 5.05
Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A (2004) 4.56
Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med (1994) 4.41
Homeostasis of memory T cells. Immunol Rev (2006) 3.69
Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity (2005) 3.39
Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol (2002) 3.22
T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol (2006) 2.94
Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem (1987) 2.94
Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol (2002) 2.76
Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med (2004) 2.47
An unusual lineage of alpha/beta T cells that contains autoreactive cells. J Exp Med (1991) 2.16
Unexpected expansions of CD8-bearing cells in old mice. J Immunol (1993) 1.98
Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules. J Immunol (1990) 1.83
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol (2005) 1.74
Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. J Exp Med (2003) 1.68
Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol (1995) 1.64
Changes in cell adhesion molecule expression on T cells associated with systemic virus infection. J Immunol (1994) 1.51
Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol (2005) 1.42
The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines. J Immunol (2001) 1.33
Age-related dysregulation in CD8 T cell homeostasis: kinetics of a diversity loss. J Immunol (2000) 1.29
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol (1998) 1.22
Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. Cancer Res (2007) 1.22
Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J Immunol (2004) 1.20
Fingerprints of anergic T cells. Curr Biol (2001) 1.19
Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction. Nucleic Acids Res (2002) 1.19
Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. J Immunol (2006) 1.19
Microglial production of TNF-alpha is induced by activated T lymphocytes. Involvement of VLA-4 and inhibition by interferonbeta-1b. J Clin Invest (1997) 1.15
A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med (2006) 1.15
Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains. J Exp Med (1982) 1.13
Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J Immunol (2006) 1.11
A functionally compromised intermediate in extrathymic CD8+ T cell deletion. Immunity (1995) 1.11
Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice. Blood (2006) 0.99
Functional subsets within clonally expanded CD8(+) memory T cells in elderly humans. Clin Immunol (2000) 0.99
Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Genes Immun (2005) 0.92
VLA-4 expression on peripheral blood lymphocytes is downregulated after treatment of multiple sclerosis with interferon beta. Neurology (1997) 0.91
Profiling the CD8low phenotype, an alternative career choice for CD8 T cells during primary differentiation. Immunol Cell Biol (2004) 0.88
Incomplete effector/memory differentiation of antigen-primed CD8+ T cells in gene gun DNA-vaccinated mice. Eur J Immunol (2003) 0.80
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood (2004) 3.19
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol (2006) 2.57
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A (2002) 2.44
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature (2009) 2.43
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood (2011) 2.20
Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol (2003) 2.09
How do adjuvants work? Important considerations for new generation adjuvants. Immunity (2007) 2.01
Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur J Immunol (2006) 1.95
A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity (2011) 1.94
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A (2010) 1.87
Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol (2002) 1.85
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity (2009) 1.85
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol (2005) 1.77
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity (2006) 1.71
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol (2003) 1.69
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A (2011) 1.68
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol (2011) 1.54
Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol (2007) 1.49
Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A (2010) 1.47
CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol (2011) 1.43
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol (2004) 1.40
Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37
T cell apoptosis and reactive oxygen species. J Clin Invest (2003) 1.35
Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev (2006) 1.33
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest (2007) 1.32
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process. Immunity (2002) 1.26
Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A (2008) 1.25
Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev (2010) 1.24
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A (2004) 1.23
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol (2012) 1.22
Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.18
Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev (2005) 1.17
Alternate interactions define the binding of peptides to the MHC molecule IA(b). Proc Natl Acad Sci U S A (2002) 1.16
Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16
Memory CD4 T cells: generation, reactivation and re-assignment. Immunology (2010) 1.16
Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum (2005) 1.14
T cells and their eons-old obsession with MHC. Immunol Rev (2012) 1.13
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood (2010) 1.12
Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol (2007) 1.12
Not all CD4+ memory T cells are long lived. Immunol Rev (2006) 1.11