Published in Immunity on March 03, 2011
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol (2011) 3.48
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol (2013) 2.89
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol (2011) 2.42
Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol (2012) 2.32
CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nat Immunol (2013) 1.93
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J Exp Med (2012) 1.71
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol (2012) 1.56
Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat Immunol (2012) 1.44
CD1d-lipid antigen recognition by the γδ TCR. Nat Immunol (2013) 1.36
New ways to turn on NKT cells. J Exp Med (2011) 1.29
Cutting edge: structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells. J Immunol (2011) 1.20
Natural Killer T cell obsession with self-antigens. Curr Opin Immunol (2013) 1.14
T cells and their eons-old obsession with MHC. Immunol Rev (2012) 1.13
Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. EMBO J (2012) 1.10
Lipid and small-molecule display by CD1 and MR1. Nat Rev Immunol (2015) 1.07
NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. J Immunol (2011) 1.04
Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A (2013) 1.02
NKT TCR recognition of CD1d-α-C-galactosylceramide. J Immunol (2011) 0.99
Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells. Immunol Rev (2012) 0.99
Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc Natl Acad Sci U S A (2011) 0.98
The regulatory role of invariant NKT cells in tumor immunity. Cancer Immunol Res (2015) 0.96
Making memory at birth: understanding the differentiation of natural killer T cells. Curr Opin Immunol (2012) 0.92
Turned on by danger: activation of CD1d-restricted invariant natural killer T cells. Immunology (2012) 0.91
SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors. Front Immunol (2014) 0.91
The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol (2015) 0.89
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex. J Biol Chem (2012) 0.88
The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. PLoS Biol (2012) 0.88
Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A (2013) 0.88
Recognition of Microbial Glycolipids by Natural Killer T Cells. Front Immunol (2015) 0.87
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology. PLoS Biol (2013) 0.87
Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol (2012) 0.86
CD1 and mycobacterial lipids activate human T cells. Immunol Rev (2015) 0.86
The CD1 size problem: lipid antigens, ligands, and scaffolds. Cell Mol Life Sci (2014) 0.84
Strategy of lipid recognition by invariant natural killer T cells: 'one for all and all for one'. Immunology (2012) 0.84
The immutable recognition of CD1d. Immunity (2011) 0.84
Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Endocrinology (2014) 0.82
The Alpha and Omega of Galactosylceramides in T Cell Immune Function. J Biol Chem (2015) 0.82
CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. Eur J Immunol (2013) 0.81
Increased numbers of NK cells, NKT-like cells, and NK inhibitory receptors in peripheral blood of patients with chronic obstructive pulmonary disease. Clin Dev Immunol (2013) 0.80
The versatility of the αβ T-cell antigen receptor. Protein Sci (2014) 0.79
Adoptive T Cell Therapy Targeting CD1 and MR1. Front Immunol (2015) 0.79
Molecules in medicine mini review: the αβ T cell receptor. J Mol Med (Berl) (2014) 0.78
CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors. J Autoimmun (2015) 0.77
Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors. PLoS One (2016) 0.77
Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation. J Biol Chem (2015) 0.77
Donor-unrestricted T cells in the human CD1 system. Immunogenetics (2016) 0.77
CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity. J Immunol Res (2016) 0.76
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. Nat Commun (2016) 0.76
The CD1 family: serving lipid antigens to T cells since the Mesozoic era. Immunogenetics (2016) 0.76
Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs. J Immunol (2016) 0.75
Invariant natural killer T cells: front line fighters in the war against pathogenic microbes. Immunogenetics (2016) 0.75
Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. J Immunol (2017) 0.75
Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells. Front Immunol (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The biology of NKT cells. Annu Rev Immunol (2007) 14.43
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med (1994) 7.35
Lysosomal glycosphingolipid recognition by NKT cells. Science (2004) 7.31
Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol (2005) 7.08
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature (1996) 6.20
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med (2000) 6.15
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol (2003) 6.07
Automated structure solution with the PHENIX suite. Methods Mol Biol (2008) 5.65
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature (2007) 5.31
Murine CD1d-restricted T cell recognition of cellular lipids. Immunity (2000) 3.57
An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med (1994) 3.47
CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol (2008) 3.37
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med (2006) 2.62
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity (2007) 2.58
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med (2007) 2.37
Mouse T-cell receptor variable gene segment families. Immunogenetics (1995) 2.24
Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med (2005) 2.18
Tissue-specific recognition of mouse CD1 molecules. J Immunol (1998) 1.98
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation. Proc Natl Acad Sci U S A (2007) 1.92
Type I natural killer T cells suppress tumors caused by p53 loss in mice. Blood (2009) 1.91
Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells. J Immunol (1998) 1.89
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity (2008) 1.89
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity (2009) 1.85
Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol (1998) 1.77
Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol (2008) 1.72
The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. J Immunol (2003) 1.69
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Blood (2009) 1.69
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc Natl Acad Sci U S A (2004) 1.61
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol (2005) 1.61
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop. PLoS Biol (2010) 1.56
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J Exp Med (2006) 1.56
The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode. J Exp Med (2010) 1.50
Determination of cellular lipids bound to human CD1d molecules. PLoS One (2009) 1.49
CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol (2007) 1.45
Natural lipid ligands associated with human CD1d targeted to different subcellular compartments. J Immunol (2009) 1.44
iNKT cell autoreactivity: what is 'self' and how is it recognized? Nat Rev Immunol (2010) 1.44
How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens. Semin Immunol (2009) 1.43
Cutting edge: influence of the TCR V beta domain on the avidity of CD1d:alpha-galactosylceramide binding by invariant V alpha 14 NKT cells. J Immunol (2003) 1.41
Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation. J Immunol (2005) 1.41
Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor. J Exp Med (1993) 1.40
NK cell-like behavior of Valpha14i NK T cells during MCMV infection. PLoS Pathog (2008) 1.39
Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc Natl Acad Sci U S A (2001) 1.22
Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res (2009) 1.11
Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected]. Proc Natl Acad Sci U S A (2010) 1.03
iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells. PLoS One (2010) 0.91
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature (2007) 5.31
The unconventional lifestyle of NKT cells. Nat Rev Immunol (2002) 4.79
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
MR1 presents microbial vitamin B metabolites to MAIT cells. Nature (2012) 3.71
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity (2003) 3.41
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol (2008) 3.37
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood (2004) 3.19
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J Exp Med (2002) 3.13
Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med (2002) 3.06
Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol (2006) 3.01
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol (2007) 2.99
Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med (2005) 2.83
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med (2002) 2.73
Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood (2002) 2.72
More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov (2007) 2.68
Homeostasis of V alpha 14i NKT cells. Nat Immunol (2002) 2.67
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A (2008) 2.57
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol (2006) 2.57
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol (2007) 2.55
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol (2005) 2.52
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol (2003) 2.48
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature (2012) 2.46
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A (2002) 2.44
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature (2009) 2.43
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol (2011) 2.42
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood (2005) 2.41
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat Immunol (2005) 2.38
A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med (2005) 2.32
Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol (2012) 2.32
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A (2003) 2.28
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
The 2.0-A crystal structure of eqFP611, a far red fluorescent protein from the sea anemone Entacmaea quadricolor. J Biol Chem (2003) 2.23
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood (2011) 2.20
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol (2008) 2.19
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci U S A (2004) 2.15
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature (2008) 2.11
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity (2011) 2.11