Published in Nat Immunol on October 15, 2006
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature (2010) 3.57
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol (2009) 2.34
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity (2012) 2.10
A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. Immunity (2011) 2.00
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides? EMBO J (2007) 1.44
Fast on-rates allow short dwell time ligands to activate T cells. Proc Natl Acad Sci U S A (2010) 1.43
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med (2011) 1.34
Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities. J Mol Recognit (2008) 1.34
How the thymus designs antigen-specific and self-tolerant T cell receptor sequences. Proc Natl Acad Sci U S A (2008) 1.32
Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology (2012) 1.30
Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell (2014) 1.19
Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol (2010) 1.15
Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection. J Immunol (2007) 1.13
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol (2008) 1.12
Evolving concepts of specificity in immune reactions. Proc Natl Acad Sci U S A (2010) 1.09
Evolutionarily conserved features contribute to αβ T cell receptor specificity. Immunity (2011) 1.06
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions. Proc Natl Acad Sci U S A (2009) 1.04
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis. J Immunol (2008) 1.00
Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens. Proc Natl Acad Sci U S A (2010) 0.96
A new twist in TCR diversity revealed by a forbidden alphabeta TCR. J Mol Biol (2007) 0.94
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry (2008) 0.94
Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol (2011) 0.92
T cell receptor specificity for major histocompatibility complex proteins. Curr Opin Immunol (2008) 0.92
Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest (2014) 0.91
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. J Clin Invest (2016) 0.90
TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines. Cancer Immunol Immunother (2012) 0.89
Functional characterization of newly-discovered mutations in human SR-BI. PLoS One (2012) 0.87
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Mol Immunol (2010) 0.87
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides. J Biol Chem (2009) 0.87
Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: implications for WT1-based cancer therapeutics. Mol Immunol (2010) 0.86
The Goldilocks model for TCR-too much attraction might not be best for vaccine design. PLoS Biol (2010) 0.86
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J Mol Biol (2013) 0.83
The effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study. J Phys Chem B (2011) 0.82
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells. Proc Natl Acad Sci U S A (2014) 0.82
Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol (2016) 0.81
Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Proc Natl Acad Sci U S A (2014) 0.81
Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts. Transplantation (2008) 0.81
On the logic of restrictive recognition of peptide by the T-cell antigen receptor. Immunol Res (2011) 0.79
Identifying environmental antigens that activate myelin-specific T cells. Trends Immunol (2014) 0.79
Characterization of antigenic variants of hepatitis C virus in immune evasion. Virol J (2011) 0.79
Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity. J Immunol (2014) 0.78
Indoctrinating T cells to attack pathogens through homeschooling. Trends Immunol (2015) 0.77
Learning from the lost: new insights into TCR specificity. Nat Immunol (2006) 0.77
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable. Nat Commun (2016) 0.77
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Mol Immunol (2012) 0.77
Two mechanisms that account for major histocompatibility complex restriction of T cells. F1000 Biol Rep (2009) 0.75
Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan. Immunology (2014) 0.75
Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production. Sci Rep (2017) 0.75
A "hotspot" for autoimmune T cells in type 1 diabetes. J Clin Invest (2016) 0.75
Response to Garcia et al. Immunity (2012) 0.75
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood (2004) 3.19
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A (2002) 2.44
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature (2009) 2.43
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood (2011) 2.20
Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol (2003) 2.09
How do adjuvants work? Important considerations for new generation adjuvants. Immunity (2007) 2.01
Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur J Immunol (2006) 1.95
A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity (2011) 1.94
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A (2010) 1.87
Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol (2002) 1.85
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity (2009) 1.85
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol (2005) 1.77
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity (2006) 1.71
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol (2003) 1.69
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A (2011) 1.68
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol (2011) 1.54
Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol (2007) 1.49
Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A (2010) 1.47
CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol (2011) 1.43
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol (2004) 1.40
Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37
T cell apoptosis and reactive oxygen species. J Clin Invest (2003) 1.35
Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev (2006) 1.33
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest (2007) 1.32
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process. Immunity (2002) 1.26
Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A (2008) 1.25
Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev (2010) 1.24
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A (2004) 1.23
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol (2012) 1.22
Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.18
Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev (2005) 1.17
Alternate interactions define the binding of peptides to the MHC molecule IA(b). Proc Natl Acad Sci U S A (2002) 1.16
Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16
Memory CD4 T cells: generation, reactivation and re-assignment. Immunology (2010) 1.16
Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A (2008) 1.16