Published in Immunity on May 12, 2011
Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol (2011) 2.92
Common patterns and disease-related signatures in tuberculosis and sarcoidosis. Proc Natl Acad Sci U S A (2012) 2.42
Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization. J Biol Chem (2014) 1.07
KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype. Leukemia (2014) 1.05
Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol (2013) 1.01
Krüppel-like factors in lymphocyte biology. J Immunol (2012) 0.97
Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am J Pathol (2013) 0.94
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Macrophages in vascular inflammation--From atherosclerosis to vasculitis. Autoimmunity (2015) 0.91
The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. J Exp Med (2016) 0.90
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report. Arterioscler Thromb Vasc Biol (2012) 0.88
Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages. BMC Genomics (2014) 0.88
Kruppel-like factor 15 is critical for vascular inflammation. J Clin Invest (2013) 0.87
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. J Biol Chem (2011) 0.86
Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis. Curr Mol Med (2012) 0.86
Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver. BMC Bioinformatics (2014) 0.85
Kruppel-like factors and vascular inflammation: implications for atherosclerosis. Curr Atheroscler Rep (2012) 0.84
Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis. Nutrients (2016) 0.84
Increased hypoxia-inducible factor 1α expression in lung cells of horses with recurrent airway obstruction. BMC Vet Res (2012) 0.82
Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest (2015) 0.80
Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1α degradation. Infect Immun (2012) 0.80
MiR-16 regulates mouse peritoneal macrophage polarization and affects T-cell activation. J Cell Mol Med (2016) 0.79
The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection. PLoS One (2014) 0.79
Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection. Virol J (2015) 0.79
Interplay between NF-κB and Kruppel-like factors in vascular inflammation and atherosclerosis: location, location, location. J Am Heart Assoc (2013) 0.79
The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens. Cell Rep (2016) 0.79
KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation. Mucosal Immunol (2016) 0.77
The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2). Blood (2014) 0.76
HIV vasculopathy: role of mononuclear cell-associated Krüppel-like factors 2 and 4. AIDS (2015) 0.76
Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses. J Immunol (2016) 0.75
Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis. J Neuroimmunol (2014) 0.75
Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis. MBio (2016) 0.75
SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization. Cell Cycle (2017) 0.75
RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet (2009) 58.77
Alternative activation of macrophages: mechanism and functions. Immunity (2010) 12.43
Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol (2009) 11.63
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Management of sepsis. N Engl J Med (2006) 9.01
Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature (2008) 6.13
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood (2003) 5.22
HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest (2005) 3.77
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med (2004) 3.69
Animal models of sepsis: setting the stage. Nat Rev Drug Discov (2005) 3.63
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med (2005) 3.43
Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 3.29
The effect of statins on mortality in patients with bacteremia. Clin Infect Dis (2001) 3.02
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Role of Krüppel-like transcription factors in endothelial biology. Circ Res (2007) 2.87
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol (2007) 2.76
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med (2009) 2.51
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res (2005) 2.49
Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46
Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol (2007) 2.46
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res (2005) 2.45
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol Cell Biol (1995) 2.41
KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood (2006) 2.41
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nat Immunol (2001) 2.36
Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha. Blood (2003) 2.28
Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction. Immunity (2001) 2.26
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A (2006) 1.95
Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosis. Circ Res (2008) 1.94
Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol (2010) 1.74
PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc Natl Acad Sci U S A (2008) 1.68
Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation. Arterioscler Thromb Vasc Biol (2006) 1.65
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol (2005) 1.57
Role of Kruppel-like factors in leukocyte development, function, and disease. Blood (2010) 1.54
Severe sepsis and septic shock: the role of gram-negative bacteremia. Annu Rev Pathol (2006) 1.38
Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem (2009) 1.12
Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am J Pathol (2009) 1.10
Kruppel-like factor 2 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol (2010) 1.09
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood (2007) 0.99
Infectogenomics: insights from the host genome into infectious diseases. Cell (2006) 0.93
Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases. Biochemistry (2005) 0.93
Coordinating innate immune cells to optimize microbial killing. Immunity (2008) 0.91
Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1. Mol Immunol (2008) 0.89
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet (2007) 8.50
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet (2008) 7.63
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Nanowire transistors without junctions. Nat Nanotechnol (2010) 5.73
Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature (2006) 4.51
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest (2005) 3.96
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med (2004) 3.69
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res (2009) 3.10
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem (2007) 3.06
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging (2002) 2.95
Role of Krüppel-like transcription factors in endothelial biology. Circ Res (2007) 2.87
A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice. Hum Mol Genet (2002) 2.80
Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med (2002) 2.68
Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell (2006) 2.64
Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem (2005) 2.62
Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet (2010) 2.56
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res (2005) 2.45
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34
Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med (2008) 2.32
Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation (2005) 2.26
Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis. Crit Care Med (2003) 2.25
Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol (2005) 2.20
Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. Heart Rhythm (2008) 2.17
BET bromodomains mediate transcriptional pause release in heart failure. Cell (2013) 2.17
The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem (2002) 2.17
Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med (2013) 2.14
3D echocardiography: a review of the current status and future directions. J Am Soc Echocardiogr (2007) 2.12
A novel role for matrix metalloproteinase-8 in sepsis. Crit Care Med (2012) 2.11
Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med (2011) 2.08
Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood (2009) 2.01
The pediatric sepsis biomarker risk model. Crit Care (2012) 1.99
Validating the genomic signature of pediatric septic shock. Physiol Genomics (2008) 1.96
Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A (2006) 1.95
Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosis. Circ Res (2008) 1.94
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem (2002) 1.90
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis. Blood (2011) 1.86
Admission angiopoietin levels in children with septic shock. Shock (2007) 1.82
Extracellular hsp70 levels in children with septic shock. Pediatr Crit Care Med (2005) 1.79
Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem (2010) 1.79
Zinc homeostasis in pediatric critical illness. Pediatr Crit Care Med (2009) 1.77
Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol (2010) 1.77
microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. Blood (2009) 1.75
Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest (2015) 1.72
Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med (2014) 1.72
Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab (2007) 1.71
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J Neurosci (2007) 1.70
Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia. Crit Care Med (2008) 1.69
Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load. J Am Soc Nephrol (2008) 1.68
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol (2002) 1.68
Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation. Arterioscler Thromb Vasc Biol (2006) 1.65
A survey of stated physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion-dependent shock. Pediatr Crit Care Med (2013) 1.63
Macrophage gene expression and foam cell formation are regulated by plasminogen. Circulation (2013) 1.63
The host response to sepsis and developmental impact. Pediatrics (2010) 1.62
Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med (2010) 1.60
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock (2002) 1.59
Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J Physiol (2005) 1.58
The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med (2011) 1.57
Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans. Am J Hum Genet (2004) 1.57
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol (2005) 1.57
Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Pediatr Crit Care Med (2010) 1.57
Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med (2014) 1.56
Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J Biol Chem (2005) 1.56
Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells. J Immunol (2006) 1.55
Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med (2009) 1.55
The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am J Physiol Heart Circ Physiol (2004) 1.55
Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate (2010) 1.54
Prolylcarboxypeptidase promotes angiogenesis and vascular repair. Blood (2013) 1.54
Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. Am J Gastroenterol (2012) 1.54
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A (2005) 1.54
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52