Published in N Engl J Med on October 19, 2006
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Pathophysiology of sepsis. Am J Pathol (2007) 3.19
Glucose variability and mortality in patients with sepsis. Crit Care Med (2008) 3.00
Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother (2007) 2.97
Sepsis: definition, epidemiology, and diagnosis. BMJ (2007) 2.43
Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock (2007) 2.37
Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int (2008) 2.37
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med (2012) 2.20
The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am (2008) 2.20
Retracted Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling. PLoS One (2010) 2.08
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci U S A (2009) 2.04
Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary Health Region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections. Antimicrob Agents Chemother (2009) 1.91
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. J Exp Med (2008) 1.89
Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J (2011) 1.86
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Molecular detection methods and serotyping performed directly on clinical samples improve diagnostic sensitivity and reveal increased incidence of invasive disease by Streptococcus pneumoniae in Italian children. J Med Microbiol (2008) 1.71
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol (2010) 1.70
Molecular epidemiology over an 11-year period (2000 to 2010) of extended-spectrum β-lactamase-producing Escherichia coli causing bacteremia in a centralized Canadian region. J Clin Microbiol (2011) 1.67
Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. J Immunol (2012) 1.61
Discovery of new biosynthetic pathways: the lipid A story. J Lipid Res (2008) 1.58
The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. BMC Med (2013) 1.56
Clinical and molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli causing bacteremia in the Rotterdam Area, Netherlands. Antimicrob Agents Chemother (2011) 1.52
SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance. J Clin Invest (2008) 1.48
Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy. Antimicrob Agents Chemother (2010) 1.47
Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines--does one size fit all? Crit Care (2008) 1.46
An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock. Minerva Anestesiol (2012) 1.44
Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor. PLoS One (2016) 1.42
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40
The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity (2011) 1.39
The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol (2010) 1.37
The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability. Crit Care (2008) 1.34
Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int (2011) 1.33
Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Antimicrob Agents Chemother (2008) 1.27
New approaches to the study of sepsis. EMBO Mol Med (2012) 1.27
Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care (2014) 1.27
Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25
Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol (2014) 1.25
Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.23
Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J (2011) 1.18
Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis. PLoS One (2009) 1.18
Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Crit Care (2011) 1.17
Dielectrophoretic microfluidic device for the continuous sorting of Escherichia coli from blood cells. Biomicrofluidics (2011) 1.17
Steady-state kinetics and mechanism of LpxD, the N-acyltransferase of lipid A biosynthesis. Biochemistry (2008) 1.17
Evaluation of FilmArray and Verigene systems for rapid identification of positive blood cultures. J Clin Microbiol (2014) 1.15
Bench-to-bedside review: sepsis - from the redox point of view. Crit Care (2011) 1.14
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol (2009) 1.14
Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock--does the dose matter? Crit Care (2009) 1.11
Systemic inflammatory response syndrome (SIRS): where did it come from and is it still relevant today? Virulence (2013) 1.10
Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant (2014) 1.09
Characteristics and outcomes of culture-negative versus culture-positive severe sepsis. Crit Care (2013) 1.08
Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance? Int J Mol Sci (2009) 1.08
Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. PLoS Pathog (2009) 1.08
Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice. Am J Physiol Renal Physiol (2009) 1.08
Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther (2008) 1.07
Advances in understanding sepsis. Eur J Anaesthesiol Suppl (2008) 1.07
A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans. PLoS Genet (2011) 1.06
The epidemiology of acute organ system dysfunction from severe sepsis outside of the intensive care unit. J Hosp Med (2013) 1.06
Automated extraction improves multiplex molecular detection of infection in septic patients. PLoS One (2010) 1.06
Volatile anesthetics improve survival after cecal ligation and puncture. Anesthesiology (2013) 1.05
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med (2013) 1.05
Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock (2011) 1.05
Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction. Crit Care (2009) 1.05
Igniting the fire: Staphylococcus aureus virulence factors in the pathogenesis of sepsis. PLoS Pathog (2014) 1.04
Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem (2009) 1.04
Acute-on-chronic liver failure. Clin Mol Hepatol (2013) 1.03
Bench-to-bedside review: circulating microparticles--a new player in sepsis? Crit Care (2010) 1.02
Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care (2010) 1.02
Presence of preexisting antibodies mediates survival in sepsis. Shock (2012) 1.01
Inflammation and haemostasis. Biochem Med (Zagreb) (2012) 1.01
Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis (2007) 1.01
Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry (2009) 1.01
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med (2012) 1.00
Serial cytokine levels in patients with severe sepsis. Inflamm Res (2009) 1.00
Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis. Crit Care (2013) 1.00
New Insight in Loss of Gut Barrier during Major Non-Abdominal Surgery. PLoS One (2008) 1.00
Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res (2010) 1.00
Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS One (2013) 0.99
Nationwide survey on resource availability for implementing current sepsis guidelines in Mongolia. Bull World Health Organ (2010) 0.99
Human serum albumin improves arterial dysfunction during early resuscitation in mouse endotoxic model via reduced oxidative and nitrosative stresses. Am J Pathol (2007) 0.99
The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol (2011) 0.98
Role of cytokines as a double-edged sword in sepsis. In Vivo (2013) 0.98
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med (2009) 0.97
Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI Biotyper and the BD Phoenix system. J Clin Microbiol (2012) 0.97
Rap1 mediates protective effects of iloprost against ventilator-induced lung injury. J Appl Physiol (1985) (2009) 0.96
A clinically applicable porcine model of septic and ischemia/reperfusion-induced shock and multiple organ injury. J Surg Res (2010) 0.96
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes. Antimicrob Agents Chemother (2012) 0.96
Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study. Crit Care (2014) 0.96
The top cited clinical research articles on sepsis: a bibliometric analysis. Crit Care (2012) 0.95
Fluoroquinolone-resistant Escherichia coli sequence type 131 isolates causing bloodstream infections in a canadian region with a centralized laboratory system: rapid emergence of the H30-Rx sublineage. Antimicrob Agents Chemother (2014) 0.95
Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors. Crit Care (2011) 0.95
Ghrelin as a novel therapy for radiation combined injury. Mol Med (2010) 0.94
Prevalence of systemic inflammatory response syndrome (SIRS) in hospitalized children: a point prevalence study. BMC Pediatr (2009) 0.94
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. J Neuroinflammation (2011) 0.94
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. Curr Neuropharmacol (2007) 0.94